Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives

Hamnerius, Nils; Svedman, Cecilia; Bergendorff, Ola; Björk, Jonas; Bruze, Magnus; Engfeldt, Malin; Pontén, Ann

doi:10.1111/cod.13042

Cited by 50 publications

(50 citation statements)

References 52 publications

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“…The authors concluded that DPG was a relevant contact allergen in sterile polyisoprene gloves, contrasting with an older study suggesting that most positive reactions to DPG were probably attributable to irritation, and were therefore false positives . A recent study by Hamnerius et al reported a large number of positive reactions to DPG, which were slightly more numerous than positive reactions to thiuram mix. Consequently, only DPG‐free medical gloves are now used in the respective hospital.…”

Section: Discussionmentioning

confidence: 89%

Allergic contact dermatitis caused by synthetic rubber gloves in healthcare workers: Sensitization to 1,3‐diphenylguanidine is common

2019

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Background: The frequency of allergic contact dermatitis has significantly increased in healthcare workers since the transition from latex to synthetic rubber gloves, with 1,3-diphenylguanidine being identified as the most frequently implicated allergen.Objectives: To highlight the role of 1,3-diphenylguanidine as the culprit allergen in contact allergies to synthetic rubber gloves, to propose recommendations for patch testing, and to discuss alternatives for sensitized subjects.Materials and methods: Patch test data from healthcare workers who developed hand dermatitis after wearing rubber gloves and who reacted positively to glove samples and rubber additives were collected from September 2010 to December 2017 in a Belgian hospital.Results: A total of 44 caregivers were included in this study. Patch tests showed that:(a) 84% of the study population reacted positively to carba mix; (b) 86% reacted positively to 1,3-diphenylguanidine; and (c) 13 (30%) reacted positively to thiuram mix.Half of the subjects reacted positively to gloves containing 1,3-diphenylguanidine, whereas none reacted to accelerator-free gloves.Conclusion: The most commonly identified allergen was 1,3-diphenylguanidine, far ahead of thiurams, which were previously described as the most sensitizing accelerators. The use of 1,3-diphenylguanidine-free gloves is recommended. No subject reacted to gloves without accelerators, thus confirming their efficiency among accelerator-sensitized patients. We recommend that 1,3-diphenylguanidine be added to the European baseline series.

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Section: Discussionmentioning

confidence: 89%

Allergic contact dermatitis caused by synthetic rubber gloves in healthcare workers: Sensitization to 1,3‐diphenylguanidine is common

2019

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“…Considerable sex differences were observed in most of the industrial activities. In particular, cleaners, hairdressers, barbers and beauticians, and healthcare workers were confirmed as occupational categories with a highly female dominance, whereas construction workers were a strictly male category 9,51,57,64,65 …”

Section: Discussionmentioning

confidence: 97%

Occupational contact dermatitis in Triveneto: Analysis of patch test data of the North Eastern Italian Database from 1996 to 2016

et al. 2020

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Background: Occupational contact dermatitis (OCD) is frequent in the workplace.Objectives: To provide recent data on the epidemiology of OCD in Italy.Methods: This multicenter retrospective study, conducted from 1996 to 2016, included patients with suspected allergic contact dermatitis (ACD) patch tested in the departments comprising the North-East Italy Contact Dermatitis Group.Results: We studied 18 859 workers with a diagnosis of contact dermatitis (CD), of which 10.4% were recognized as being of professional origin. OCD declined from 1996 to 2011-2013 and increased in 2014-2016. The overall prevalence of both CD and OCD was higher in women compared to men, but the share of OCD of the total CD was greater for men compared to women. A history of atopic dermatitis was less frequent in workers with OCD than in non-OCD patients (5.8% vs 8.6%). Hairdressers were the youngest profession (27.1 ± 11.7 years). Hands were the primary site of involvement in patients with OCD (76.6%). The five highest risk occupations for OCD were hairdressers, cooks, metalworkers, chemical industry workers, and construction workers. Conclusions:OCDs have a relevant impact in our region, mainly for five job categories, and the increase in the last 3 years suggests the need to improve preventive measures.

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“…Accelerators are the most common cause of contact dermatitis due to rubber gloves. Hamnerius et al have reported that the allergens responsible for allergic contact dermatitis is as common for diphenylguanidine as it is for thiurams. However, it is also true that chemicals that are not accelerators have been reported to also cause contact dermatitis .…”

Section: Discussionmentioning

confidence: 99%

Contact dermatitis due to 2,2,4‐trimethyl 1,3‐pentanediol diisobutyrate contained in latex‐free, accelerator‐free nitrile rubber gloves

Nishioka¹,

Koizumi²,

Takita³

et al. 2020

Contact Dermatitis

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Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives

Abstract: Contact allergy to rubber additives in medical gloves is the most common cause of occupational allergic contact dermatitis in HCWs. Aimed patch testing with relevant rubber additives is mandatory when HE in HCWs is investigated.

Cited by 50 publications

References 52 publications

Allergic contact dermatitis caused by synthetic rubber gloves in healthcare workers: Sensitization to 1,3‐diphenylguanidine is common

Allergic contact dermatitis caused by synthetic rubber gloves in healthcare workers: Sensitization to 1,3‐diphenylguanidine is common

Occupational contact dermatitis in Triveneto: Analysis of patch test data of the North Eastern Italian Database from 1996 to 2016

Contact dermatitis due to 2,2,4‐trimethyl 1,3‐pentanediol diisobutyrate contained in latex‐free, accelerator‐free nitrile rubber gloves

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