Contact dermatitis due to 2,2,4‐trimethyl 1,3‐pentanediol diisobutyrate contained in latex‐free, accelerator‐free nitrile rubber gloves

Nishioka, Kazue; Koizumi, Akiko; Takita, Yuko; Sasaki, Koichi; Numata, Masahiro

doi:10.1111/cod.13455

Cited by 4 publications

(1 citation statement)

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“…The absence of detection of allergens in patients with positive tests to gloves could be explained by the fact that all potential glove allergens are not available in marketed preparations for patch testing. Some new allergens would be useful: 2,2,4‐trimethyl 1,3‐pentanediol diisobutyrate which is a component present in PVC gloves but also in nitrile gloves, 41 poly(adipic acid‐co‐1,2‐propylene glycol), mono(2‐ethylhexyl) maleate, bis(2‐ethylhexyladipate) and triphenylphosphite which are present in PVC gloves 17–19 . Consideration should also be given to possible sensitisation to the dyes present in gloves 42 …”

Section: Discussionmentioning

confidence: 99%

Hand eczema in glove‐wearing patients

et al. 2023

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Background Allergic contact dermatitis to gloves is mostly induced by rubber accelerators. The European baseline series (EBS) appears insufficient to detect glove allergy. Since 2017, it is recommended to use the European rubber series (ERS) and to test the patients' own gloves. Objectives To investigate the clinical profile of glove‐wearing patients with hand eczema (HE) and to evaluate their sensitisation profile to glove allergens and the value of testing the patients' own gloves. Methods We conducted a French multicentre study of patients evaluated for HE between 2018 and 2020 and tested with the EBS, the ERS and their own gloves in patch tests and semi‐open (SO) tests. Results A total of 279 patients were included; 32.6% of patients had positive tests to their own gloves or to glove allergens. Almost 45% of the sensitisations to glove allergens were detected only by the ERS. Among the patients tested both in patch tests and SO tests with their own gloves with positive results, 28% had positive SO tests only. Polyvinylchloride (PVC) gloves were positive in four patients. Conclusion Our series confirms the need to test the ERS. All the patients' gloves must also be tested including PVC gloves. SO tests with gloves are useful as a complement to patch tests.

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Section: Discussionmentioning

confidence: 99%