Sleep disorders among Yusho patients highly intoxicated with dioxin-related compounds: A 140-case series

Kondo, Hideaki; Tanio, Keiko; Nagaura, Yuki; Nagayoshi, Mako; Mitoma, Chikage; Furue, Masutaka; Maeda, Takahiro

doi:10.1016/j.envres.2018.05.033

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…Of the two studies of phthalates exposure, an analysis in the Midlife Women’s Health Study did not report an association with insomnia or sleep disturbance except in former smokers; an analysis of NHANES participants ages 16-17 did report higher odds for short (<8 hours) weekday sleep duration among those in the highest quartile of phthalate exposure, but did not consider school start times or the influence of puberty and chronotype on the outcome[133]. An analysis of 140 people exposed to PCBs from contaminated rice bran reported worse sleep quality and higher prevalence of difficulty initiating sleep among those in the highest quartile of exposure[134]. Case studies of residents living in methamphetamine-contaminated homes [135] and homes with off-gassing from polyurethane foam insulation[136] highlighted reports of sleep disturbance and insomnia.…”

Section: Resultsmentioning

confidence: 99%

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

Wallace

Gallagher

Peterson

et al. 2022

Preprint

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Background: Sleep disruption is a public health concern and environmental exposures that influence the biological processes underpinning sleep may contribute to impaired sleep health. However, the contributions of environmental chemical pollutants to sleep health have not been systematically investigated. Objectives: This systematic literature review sought to identify, evaluate, summarize, and synthesize the existing evidence between environmental chemical pollutant exposure and dimensions of sleep health in humans. We sought to evaluate potential mechanisms underlying exposure-outcome relationships and recommend areas for future research. Methods: Databases were searched for peer-reviewed published research on chemical environmental pollutants and sleep health and disorders with no date restriction up to the last search date of April 2021 (registered protocol PROSPERO # CRD42021256918), resulting in 9,918 records. Two reviewers independently screened identified records against inclusion and exclusion criteria, extracted study information, and performed risk of bias assessments. Results: We identified 204 studies of exposure to air pollution, exposures related to the Gulf War and other conflicts, endocrine disruptors, metals, pesticides, and solvents with dimensions of sleep health (architecture, duration, quality, timing) and sleep disorders (sleeping pill use, insomnia, sleep-disordered breathing) for inclusion in this review. Metals were the most frequently evaluated pollutants, while sleep maintenance/insomnia and quality were the most reported sleep outcomes. Synthesis of the evidence suggests mechanisms related to cholinergic signaling, neurotransmission, and inflammation as the most shared pathways. Discussion: Evidence indicates that exposure to particulate matter, secondhand smoke, dioxins and dioxin-like compounds, lead, mercury, pesticides, solvents, and exposures related to the Gulf War are associated with worse sleep health and disorders. Chemical pollutants are likely key environmental determinants of sleep health and disorders; thus, there is a need to improve measurement of pollutants and sleep, study rigor, and determine the populations most vulnerable to the effects of exposure.

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Section: Resultsmentioning

confidence: 99%

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

Wallace

Gallagher

Peterson

et al. 2022

Preprint

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“…Also, the Yu-Cheng (Taiwan) and Yusho (Japan) food poisonings are two well-known cases of edible oil contamination. The average intake of PCBs, PCDFs, and polychlorinated quarter phenyls (PCQs) through ingestion of contaminated Kanemi rice oil for a group of Yusho patients was calculated to be 154000 pg I-TEQ/kg bw/day, which is five times greater than the reported background ingestion average in numerous nations [27].…”

Section: B Accidental Exposurementioning

confidence: 87%

The promising protective effect of locust bean against hepatotoxicity of Dioxins and dioxin like compounds

Dahy

2023

Frontiers in Scientific Research and Technology

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In recent years, waste generation tends to increase in quantity as the population and living circumstances increase. Uncontrolled waste incinerators (solid waste and hospital waste) are frequently the worst offenders when it comes to dioxin leakage into the environment because of incomplete burning. Dioxins are a type of persistent organic pollutants (POPs). Dioxins are primarily by-products of industrial operations such as smelting, chlorine bleaching of paper pulp, and the production of various herbicides and insecticides, although they can also be produced by natural events like volcanic eruptions and forest fires. Dioxins have an impact on several organs and systems. Dioxins removal from the ecosystem is challenging due to their persistence, resistance to biodegradation, and pervasiveness, and now dioxins toxicity is recognized as a problem that needs to be addressed right away. Nowadays, increasing attention has been paid to natural antioxidant compounds with fewer detrimental effects such as locust beans to reduce the toxicity of different chemicals. Locust bean seeds mostly include galactomannans and flavonoids which are antioxidants and are essential in protecting cells from free radicals, which may also be beneficial in liver disease, cancer, and other diseases. Locust beans also may increase the removal of dioxin from the body. Hence, in the current review, we shed light on the promising protective effect of Locust beans against the hepatotoxicity of dioxins and dioxin-like compounds [1].

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“…8 Polychlorinated biphenyls exposure induced higher prevalence of difficultly initiating sleep (DIS) among those in the top quartile of exposure. 9 The disrupting thyroid hormone signaling, cholinergic signaling, and circadian clock function of human beings by environmental chemical pollutants might contribute to sleep impairment. 10 Hence, it is warranted to estimate the causal relationship between environmental pollutants and sleep health.…”

Section: Introductionmentioning

confidence: 99%

“…Children with high occurrence of polybrominated diphenyl ethers in cord‐blood showed greater sleep problem compared with those in the low tertile at 4 years old 8 . Polychlorinated biphenyls exposure induced higher prevalence of difficultly initiating sleep (DIS) among those in the top quartile of exposure 9 . The disrupting thyroid hormone signaling, cholinergic signaling, and circadian clock function of human beings by environmental chemical pollutants might contribute to sleep impairment 10 .…”

Section: Introductionmentioning

confidence: 99%

Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse

Guo,

He,

Mao

et al. 2024

Environmental Toxicology

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Although the stimulative effects on the normal behaviors of fish posed by ketamine (KET) were well‐studied, the adverse effects on the behavioral functions induced by KET at nighttime were unknown. Here, we used zebrafish larvae as a model exposed to KET (10, 50, 100, and 250 ng/L) at environmental levels for 21 days. The behavioral functions at nighttime, morphological changes during exposure stage, and alterations on the associated genes transcriptional levels of fish were determined. The difficultly initiating sleep was found in the fish exposed to KET, while the sleep duration of the animals was at the normal levels in exposure groups. The significant suppressions of the developmentally relevant genes, including bmp2, bmp4, and pth2ra were consistent with the developmental abnormalities of fish found in exposure groups. Moreover, the expression of γ‐aminobutyric acid (GABA) receptor increased and melatonin (MTN) receptor decreased while the levels of GABA and MTN remained unchanged after exposure, by gene expression analysis and molecular docking. In addition, the transcriptional expression of apoptotic genes, including tp53, aifm1, and casp6, was significantly upregulated by KET. After a 7‐day recovery, the insomnia‐like behaviors (shorter sleep duration) were observed in zebrafish from the 250 ng/L‐KET group. Accordingly, the adverse outcome pathway framework of KET was constructed by prognostic assessment of zebrafish larvae. This study suggested that the adverse outcomes of KET on the sleep health of organisms at environmentally relevant concentrations should be concerned.

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Sleep disorders among Yusho patients highly intoxicated with dioxin-related compounds: A 140-case series

Abstract: Symptoms of insomnia were frequent, and the prevalence of RLS/WED was high in patients with Yusho. In addition to the presence of RLS/WED, a higher blood concentration of 2,3,4,7,8-PeCDF was associated with lower subjective sleep quality.

Cited by 7 publications

References 39 publications

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

The promising protective effect of locust bean against hepatotoxicity of Dioxins and dioxin like compounds

Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse

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