Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse
Tingting Guo,
Yuhang He,
Shengqiang Mao
et al.
Abstract:Although the stimulative effects on the normal behaviors of fish posed by ketamine (KET) were well‐studied, the adverse effects on the behavioral functions induced by KET at nighttime were unknown. Here, we used zebrafish larvae as a model exposed to KET (10, 50, 100, and 250 ng/L) at environmental levels for 21 days. The behavioral functions at nighttime, morphological changes during exposure stage, and alterations on the associated genes transcriptional levels of fish were determined. The difficultly initiat… Show more
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