Kinetic studies of complex biomedical process by magnetic resonance: Cuban experiences

Abstract

The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with molecular, preclinical and clinical studies of significant diseases and drugs development. MR “in vitro” and “in vivo” studies of sickle cell disease, the diabetic foot ulcer, the brain tumor response and the magnetic nano-particle pharmacokinetics, are presented as example. Furthermore, contributions and restrictions of magnetic resonance to diagnostic and optimization of therapeutic pathways are discussed in some concrete cases.

Determination of Dynamic Viscosity in Samples of Blood Plasma and Hemoglobin Solution Using Nuclear Magnetic Resonance

“…In our experiments we used glass ampules with 500 µL of sample volume. This volume guarantees that the signal-to-noise ratio is adequate to perform the measurements in the equipment, achieving the best homogeneity for the external magnetic field imposed by the system and the radio frequency field that is created in the receiver-transmitter coil [9].…”