Evaluation of an artificial vertebral body fabricated by a tantalum-coated porous titanium scaffold for lumbar vertebral defect repair in rabbits

Wang, Faqi; Wang, Lin; Yan, Feng; Yang, Xuan; Ma, Zhen; Shi, Lei; Ma, Xiangyu; Wang, Jian; Ma, Tao; Wen, Xinxin; Zhang, Yang; Lei, Wei

doi:10.1038/s41598-018-27182-x

Cited by 18 publications

(14 citation statements)

References 44 publications

(47 reference statements)

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“…The surface topological nanoscale structure has a vital effect on the adhesion, migration, and morphology of osteoblasts ( Gittens et al, 2011 ; Puckett et al, 2008 ; Khrunyk et al, 2020 ; Yeo, 2019 ). In addition, the Ta ion function has also been proven to enhance the growth and differentiation of osteoblasts, which combined with the nanostructure synergistically enhances the cellular responses ( Wang et al, 2018 ). A previous study has demonstrated that the nanostructured surfaces exhibited superior hydrophilicity and excellent protein adsorption behavior, thus, the well-elongated MC3T3-E1 cells with mature and thick pseudopodia could be observed on the Mg/FHA and Mg/FHA/Ta surface ( Li et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Cao

Yang

et al. 2021

Front. Chem.

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Magnesium (Mg) alloys have a wide range of biomaterial applications, but their lack of biocompatibility and osteoinduction property impedes osteointegration. In order to enhance the bioactivity of Mg alloy, a composite coating of fluorinated hydroxyapatite (FHA) and tantalum (Ta) was first developed on the surface of the alloy through thermal synthesis and magnetron sputtering technologies in this study. The samples were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDS) mapping, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and water contact angle measurement (WCA), which characterized the surface alternation and confirmed the deposition of the target FHA/Ta coating. The results of cell morphology showed that the MC3T3-E1 cells on the surface of Mg/FHA/Ta samples had the largest spreading area and lamellipodia. Moreover, the FHA coating endowed the surface with superior cell viability and osteogenic properties, while Ta coating played a more important role in osteogenic differentiation. Therefore, the combination of FHA and Ta coatings could synergistically promote biological functions, thus providing a novel strategy for implant design.

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Section: Resultsmentioning

confidence: 99%

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Cao

Yang

et al. 2021

Front. Chem.

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“…In the present study, we did not choose the long time points (e.g., 12 or 36 weeks), because the early osteogenesis is vital in achievement of mechanical stability at early stage. For rodents, duration of recovery within 2 months or longer is enough to fully heal the bone damage, and 4 to 5 weeks is effective and sufficient for observing the early bone formation (60)(61)(62)(63). Implants that are designed with a porous structure can decrease stiffness and avoid the stress shielding effect.…”

Section: Discussionmentioning

confidence: 99%

Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds

Lijun

et al. 2019

Ann. Transl. Med

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Background: Titanium implants are widely used in orthopedic and dental for more than 30 years. Its stable physicochemical properties and mechanical strength are indeed appropriate for implantation. However, the Bioinertia oxidized layer and higher elastic modulus often lead to the early implantation failure. Methods: In this study, we proposed a simple design of porous structure to minimize the disparity between scaffold and natural bone tissue, and introduced a one-step reaction to form a polydopamine (PDA) layer on the surface of titanium for the purpose of improving osteogenesis as well. The porous scaffolds with pore size of 400 μm and porosity of 44.66% were made by additive manufacturing. The cell behavior was tested by seeding MC3T3-E1 cells on Ti6Al4V films for 15 days. The biomechanical properties were then analyzed by finite element (FE) method and the in vivo osteogenesis effect was accordingly evaluated by implanting the scaffolds for 5 weeks in rabbits. Results: According to the achieved results, it was revealed that the immersion for 40 min with dopamine could significantly improve the cell adhesion. The proposed method for design of porous structure can avoid the stress shielding effect and bone growth inside the PDA coating scaffolds, which were observed at the early stage of bone healing process. Conclusions: It can be concluded that the proposed PDA coating method is effective in promoting early osteogenesis, as well as being easy to operate, and can be helpful in the future clinical application of titanium implants.

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“…Different metals have different properties; for example, tantalum, gray metal with similar physical properties to titanium, can accelerate the natural mineral deposits in body fluids through the activation of the Wnt/ beta and transforming growth factor-β (TGF-β)/drosophila mothers against decapentaplegic protein (Smad) signaling pathways, which could mediate osteogenesis (62). Wang et al (63) manufactured a nanotube array coating with tantalum on the titanium alloy scaffold and then seeded adipose-derived stem cells on the coating. The subsequent animal experiment on a rabbit spinal defect model confirmed that it significantly promoted osteogenesis.…”

Section: Coating Technologymentioning

confidence: 99%

Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review

Zuo

Lin

et al. 2021

Ann Transl Med

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Owing to their excellent biocompatibility and corrosion-resistant properties, titanium (Ti) (and its alloy) are essential artificial substitute biomaterials for orthopedics. However, flaws, such as weak osteogenic induction ability and higher Young's modulus, have been observed during clinical application. As a result, short-and long-term postoperative follow-up has found that several complications have occurred.For decades, scientists have exerted efforts to compensate for these deficiencies. Different modification methods have been investigated, including changing alloy contents, surface structure transformation, threedimensional (3D) structure transformation, coating, and surface functionalization technologies. The cellsurface interaction effect and imitation of the natural 3D bone structure are the two main mechanisms of these improved methods. In recent years, significant progress has been made in materials science research methods, including thorough research of titanium alloys of different compositions, precise surface pattern control technology, controllable 3D structure construction technology, improvement of coating technologies, and novel concepts of surface functionalization. These improvements facilitate the possibility for further research in the field of bone tissue engineering. Although the underlying mechanism is still not fully understood, these studies still have some implications for clinical practice. Therefore, for the direction of further research, it is beneficial to summarize these studies according to the basal method used. This literature review aimed to classify these technologies, thereby providing beginners with a preliminary understanding of the field.

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Evaluation of an artificial vertebral body fabricated by a tantalum-coated porous titanium scaffold for lumbar vertebral defect repair in rabbits

Cited by 18 publications

References 44 publications

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys

Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds

Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review

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