Experience of Perinatal and Neonatal Chikungunya Virus (CHIKV) Infection in a Tertiary Care Neonatal Centre during Outbreak in North India in 2016: A Case Series

Kumar, Surender; Agrawal, Gopal; Wazir, Sanjay; Kumar, Anil; Dubey, Sandeep; Balde, Manish; Yadav, Bir Singh

doi:10.1093/tropej/fmy032

Cited by 20 publications

(28 citation statements)

References 15 publications

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“…Except two women in our report, no other pregnant women were infected by CHIKV during the intrapartum period. Thus, in the three neonates born to two women with intrapartum infection, the risk of perinatal vertical transmission is 100%, which is similar to that observed in Reunion island, Brazil, Colombia and India (Lenglet et al 2006 ; Villamil-Gomez et al 2015 ; Bandeira et al 2016 ; Lyra et al 2016 ; Kumar et al 2019 ). In contrast, of 15 women delivered during acute CHIKV infection, as reported in 2015 in Colombia, 12 neonates were hospitalized to rule out vertical transmission, though no clinical findings suggestive of neonatal CHIKV infection were observed (Escobar et al 2017 ).…”

supporting

confidence: 70%

“…Thereafter, sporadic CHIKV infection through perinatal vertical transmission was observed in the Island of Curacao (van Enter et al 2018 ), Brazil (Bandeira et al . 2016 ; Lyra et al 2016 ), Colombia (Villamil-Gomez et al 2015 ) and India (Kumar et al 2019 ). In a retrospective study in Thailand and a cohort study in Colombia, however, no clinical findings suggestive of perinatal vertical transmission were observed (Laoprasopwattana et al 2016 ; Escobar et al 2017 ).…”

mentioning

confidence: 99%

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Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar

Shen

Xie

et al. 2020

Virol. Sin.

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supporting

confidence: 70%

mentioning

confidence: 99%

Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar

Shen

Xie

et al. 2020

Virol. Sin.

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“…Most studies (n = 35; 83,3%) were case reports and case series [9,[16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][45][46][47][48][49][51][52][53]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [9,10,[16][17][18][19][20][21]23,25,27,[49][50][51].…”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…All included studies (n = 42) reported CHIKV vertical transmission confirmed by laboratory and clinical-epidemiological evidence in pregnant women (Table 1). The maternal infection diagnosis was confirmed by molecular and serological tests in 31 (73.8%) studies [6,9,10,[16][17][18][19][20][21][22][23][24][25][26][27][28]30,31,[33][34][35]39,41,[43][44][45][47][48][49][50][51]53,54] and in 243 (96.8%) women.…”

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded. Results From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life. Conclusions We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.

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“…In India, severe manifestations of the ECSA genotype with the E1: K211E and E2: V264A mutations were reported in congenital and neonatal infections (Table 1) [55]. Specifically, encephalitis, hyperpigmentation, and severe cutaneous lesions were commonly seen in neonates and infants [55,93,94,121,122,123,124]. Other common symptoms included lethargy, poor feeding, and hypotonia [94,123].…”

Section: Chikv In Neonates and Children After Global Expansionmentioning

confidence: 99%

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

Barr

Vaidhyanathan

2019

Viruses

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Chikungunya virus (CHIKV) was first extensively described in children during outbreaks in India and South Asia during the mid-1960s. Prior to the 2005 emergence of CHIKV on Reunion Island, CHIKV infection was usually described as a dengue-like illness with arthralgia in Africa and febrile hemorrhagic disease in Asia. Soon after the 2005 emergence, severe CNS consequences from vertical and perinatal transmission were described and as CHIKV continued to emerge in new areas over the next 10 years, severe manifestation of infection and sequelae were increasingly reported in infants and neonates. The following review describes the global reemergence and the syndromes of Chikungunya fever (CHIKF) in infants and children. The various manifestations of CHIKF are described and connected to the viral lineage that was documented in the area at the time the disease was described. The data show that certain manifestations of CHIKF occur with specific viral lineages and genetic motifs, which suggests that severe manifestations of CHIKF in the very young may be associated with the emergence of new viral lineages.

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Experience of Perinatal and Neonatal Chikungunya Virus (CHIKV) Infection in a Tertiary Care Neonatal Centre during Outbreak in North India in 2016: A Case Series

Abstract: In endemic areas, paediatricians should have a low threshold of suspicion for perinatal or neonatal chikungunya in any infant presenting with signs and symptoms mimicking sepsis, especially with skin manifestations, seizure and/or encephalopathy.

Cited by 20 publications

References 15 publications

Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar

Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar

Vertical transmission of chikungunya virus: A systematic review

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

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