Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar

Shen, Jianhong; Li, Man; Xie, Lyu; Mao, Jiarong; Zhou, Hongning; Wang, Peigang; Jiang, Jin-Yong; An, Jing

doi:10.1007/s12250-020-00245-y

Cited by 6 publications

(6 citation statements)

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“…Among the different age groups (Figure 3), the number of cases between 50 and 60 years old was the highest, with 27 cases (24.11%). Due to three cases of neonatal infections caused by vertical transmission, as described by Shen et al, 16 a small peak also appeared in the 0–10‐year‐old group. The occupations of the patients were mostly merchants (35/112, 31.25%) and unemployed people (30/112, 26.79%), followed by students (10/112, 8.93%) and farmers (6/112, 5.36%).…”

Section: Resultsmentioning

confidence: 80%

Epidemiological and clinical characteristics of the chikungunya outbreak in Ruili City, Yunnan Province, China

Liu

Gao

et al. 2021

Journal of Medical Virology

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Chikungunya fever is an acute infectious disease caused by the chikungunya virus (CHIKV) that is characterized by fever, rash, and joint pain. CHIKV has infected millions of people in Africa, Asia, America, and Europe since it re-emerged in the Indian Ocean region in 2004. Here, we report an outbreak of Chikungunya fever that occurred in Ruili of Yunnan Province, a city located on the border between China and Myanmar, in September 2019. The outbreak lasted for three months from September to December. Overall, 112 cases were confirmed by a real-time reversetranscription polymerase chain reaction in the Ruili People's Hospital, and they showed apparent temporal, spatial, and population aggregation. Among them, 91 were local cases distributed in 19 communities of Ruili City, and 21 were imported cases. The number of female patients was higher than that of male patients, and most patients were between 20 and 60 years old. The main clinical manifestations included joint pain (91.96%), fever (86.61%), fatigue (58.04%), chills (57.14%), rash (48.21%), headache (39.29%), and so forth. Biochemical indexes revealed increased C-reactive protein (63.39%), lymphopenia (57.17%), increased hemoglobin (33.04%), neutrophilia (28.57%), and thrombocytopenia (16.07%). Phylogenetic analysis of the complete sequences indicated that the CHIKV strains in this outbreak belonged to the Indian Ocean clade of the East/Central/South African genotype. We speculated that this chikungunya outbreak might be caused by CHIKV-infected persons returning from Myanmar, and provided a reference for the formulation of effective treatment and prevention measures.

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Section: Resultsmentioning

confidence: 80%

Epidemiological and clinical characteristics of the chikungunya outbreak in Ruili City, Yunnan Province, China

Liu

Gao

et al. 2021

Journal of Medical Virology

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“…The literature search retrieved 227 publications; after exclusion of 71 duplicates, 136 titles were evaluated regarding the established inclusion and exclusion criteria. Of these, 64 were excluded based on the title (19) and abstract (45) (Fig 1). The final selection resulted in 42 articles: 28 case reports, seven case series, two cross-sectional study and five cohort studies.…”

Section: -Resultsmentioning

confidence: 99%

“…Most studies (n = 35; 83,3%) were case reports and case series [9,[16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][45][46][47][48][49][51][52][53]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [9,10,[16][17][18][19][20][21]23,25,27,[49][50][51]. Stillbirths and miscarriage associated with CHIKV vertical transmission with laboratory evidence were reported in three studies …”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…All included studies (n = 42) reported CHIKV vertical transmission confirmed by laboratory and clinical-epidemiological evidence in pregnant women (Table 1). The maternal infection diagnosis was confirmed by molecular and serological tests in 31 (73.8%) studies [6,9,10,[16][17][18][19][20][21][22][23][24][25][26][27][28]30,31,[33][34][35]39,41,[43][44][45][47][48][49][50][51]53,54] and in 243 (96.8%) women.…”

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded. Results From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life. Conclusions We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.

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“…Vertically infected neonates develop various clinical symptoms ( Robillard et al, 2006 ; Beserra et al, 2019 ). At the time of birth, about half of the viremic mothers transmit the virus to neonates that results in serious consequences to the neonates ( Contopoulos-Ioannidis et al, 2018 ; van Enter et al, 2018 ; Shen et al, 2020 ). About 50% infected neonates develop symptoms within 3–7 days.…”

Section: Clinical Features Of Patients Infected With Chikvmentioning

confidence: 99%

Molecular Epidemiology, Evolution and Reemergence of Chikungunya Virus in South Asia

et al. 2021

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Chikungunya virus (CHIKV) is a vector (mosquito)-transmitted alphavirus (family Togaviridae). CHIKV can cause fever and febrile illness associated with severe arthralgia and rash. Genotypic and phylogenetic analysis are important to understand the spread of CHIKV during epidemics and the diversity of circulating strains for the prediction of effective control measures. Molecular epidemiologic analysis of CHIKV is necessary to understand the complex interaction of vectors, hosts and environment that influences the genotypic evolution of epidemic strains. In this study, different works published during 1950s to 2020 concerning CHIKV evolution, epidemiology, vectors, phylogeny, and clinical outcomes were analyzed. Outbreaks of CHIKV have been reported from Bangladesh, Bhutan, India, Pakistan, Sri Lanka, Nepal, and Maldives in South Asia during 2007–2020. Three lineages- Asian, East/Central/South African (ECSA), and Indian Ocean Lineage (IOL) are circulating in South Asia. Lineage, ECSA and IOL became predominant over Asian lineage in South Asian countries during 2011–2020 epidemics. Further, the mutant E1-A226V is circulating in abundance with Aedes albopictus in India, Bangladesh, Nepal, and Bhutan. CHIKV is underestimated as clinical symptoms of CHIKV infection merges with the symptoms of dengue fever in South Asia. Failure to inhibit vector mediated transmission and predict epidemics of CHIKV increase the risk of larger global epidemics in future. To understand geographical spread of CHIKV, most of the studies focused on CHIKV outbreak, biology, pathogenesis, infection, transmission, and treatment. This updated study will reveal the collective epidemiology, evolution and phylogenies of CHIKV, supporting the necessity to investigate the circulating strains and vectors in South Asia.

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Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar

Cited by 6 publications

References 16 publications

Epidemiological and clinical characteristics of the chikungunya outbreak in Ruili City, Yunnan Province, China

Epidemiological and clinical characteristics of the chikungunya outbreak in Ruili City, Yunnan Province, China

Vertical transmission of chikungunya virus: A systematic review

Molecular Epidemiology, Evolution and Reemergence of Chikungunya Virus in South Asia

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