In vitro effects of brominated flame retardants, selected metals and their mixtures on ethoxyresorufin-O-deethylase activity in Mossambica tilapia liver

Wang, Biyan; Wang, Haiyan; Xiao, Dan; Han, Dong

doi:10.1016/j.ecoenv.2018.05.084

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…Ronisz et al (2004) published evidence that TBBPA inhibited EROD activity, but HBCD had no effect at 2000 mg/L or 10 g/L. In contrast, Wang et al (2018) reported an increased EROD activity at 0.001-10 µg/L TBBPA and 0.001-0.1 µg/L BDE-209, at concentrations lower or higher than this activity did not change. HBCD inhibited EROD activity at all concentrations tested.…”

Section: Studies Ex Vivo and In Vitro On Brominated Organic Compoundsmentioning

confidence: 98%

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Artabe

Cunha-Silva

Barranco

2020

Food and Chemical Toxicology

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Halogenated organic compounds are a particular group of contaminants consisting of a large number of substances, and of great concern due to their persistence in the environment, potential for bioaccumulation and toxicity. Some of these compounds have been classified as persistent organic pollutants (POPs) under The Stockholm Convention and many toxicity assessments have been conducted on them previously. In this work we provide an overview of enzymatic assays used in these studies to establish toxic effects and dose-response relationships. Studies in vivo and in vitro have been considered with a particular emphasis on the impact of halogenated compounds on the activity of relevant enzymes to the humans and the environment. Most information available in the literature focuses on chlorinated compounds, but brominated and fluorinated molecules are also the target of increasing numbers of studies. The enzymes identified can be classified as enzymes: i) the activities of which are affected by the presence of halogenated organic compounds, and ii) those involved in their metabolisation/detoxification resulting in increased activities. In both cases the halogen substituent seems to have an important role in the effects observed. Finally, the use of these enzymes in biosensing tools for monitoring of halogenated compounds is described.

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Section: Studies Ex Vivo and In Vitro On Brominated Organic Compoundsmentioning

confidence: 98%

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Artabe

Cunha-Silva

Barranco

2020

Food and Chemical Toxicology

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“…Additionally, in 2018, regarding the studies in vitro, Wang et al studied the effects of HBCD on the liver of Mossambica tilapia. The results showed that exposure to HBCD caused a decrease in the activity of EROD, an enzyme used as a biomarker of compounds, such as HBCD [ 98 ].…”

Section: Studies In Animal Modelsmentioning

confidence: 99%

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

Marques

Cairrão

2023

Toxics

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Hexabromocyclododecane (HBCD) is a non-aromatic compound belonging to the bromine flame retardant family and is a known persistent organic pollutant (POP). This compound accumulates easily in the environment and has a high half-life in water. With a variety of uses, the HBCD is found in house dust, electronics, insulation, and construction. There are several isomers and the most studied are α-, β-, and γ-HBCD. Initially used as a substitute for other flame retardants, the polybrominated diphenyl ethers (PBDEs), the discovery of its role as a POP made HBCD use and manufacturing restricted in Europe and other countries. The adverse effects on the environment and human health have been piling, either as a result from its accumulation or considering its power as an endocrine disruptor (ED). Furthermore, it has also been proven that it has detrimental effects on the neuronal system, endocrine system, cardiovascular system, liver, and the reproductive system. HBCD has also been linked to cytokine production, DNA damage, increased cell apoptosis, increased oxidative stress, and reactive oxygen species (ROS) production. Therefore, this review aims to compile the most recent studies regarding the negative effects of this compound on the environment and human health, describing the possible mechanisms by which this compound acts and its possible toxic effects.

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Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway

et al. 2019

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In vitro effects of brominated flame retardants, selected metals and their mixtures on ethoxyresorufin-O-deethylase activity in Mossambica tilapia liver

Cited by 7 publications

References 43 publications

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway

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In vitro effects of brominated flame retardants, selected metals and their mixtures on ethoxyresorufin-O-deethylase activity in Mossambica tilapia liver

Cited by 7 publications

References 43 publications

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway

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Product

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Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway