Higher Prevalence of Endometrial Polyps in Infertile Patients with Endometriosis

Abstract

Aim: To study whether infertile patients with endometriosis have a higher prevalence of endometrial polyps, and to clarify the characteristics of the pathology of combined polyps. Methods: Infertile patients who had undergone both hysteroscopy and laparoscopy in Reproductive Hospital Affiliated with Shandong University from January 2014 to May 2017 were enrolled. Patients with and without endometriosis, diagnosed by laparoscopy, were staged and included in the study group and control group, respectively, and the prevalence of polyps was compared. The pathological types of endometrial polyps were analyzed. Results: A total of 414 cases were enrolled in the study group and 3,048 cases in the control group; polyps were diagnosed, with endoscopy, in 1,107 patients. Endometrial polyps were detected by hysteroscopy in 47.83% of the endometriosis group and 29.82% of the control group. The prevalence of endometrial polyps was significantly higher in the endometriosis group than in the control group (p < 0.001) but not significantly different between stages of endometriosis (p = 0.580). The pathological diagnosis included 899 endometrial polyps and 208 polypoid hyperplasia; 66.5% of endometrial polyps were combined with simple hyperplasia. Conclusions: The infertile patients with endometriosis had a higher prevalence of endometrial polyps, and those polyps are often combined with simple hyperplasia.

Effect of human chorionic gonadotropin injection before frozen embryo transfer on pregnancy outcomes in endometriosis infertility

“…Reduced implantation, clinical pregnancy rate, ongoing pregnancy and live birth rate was found in women with endometriosis placing sibling oocytes from same donor, comparing women without endometriosis [13]. We also found that higher prevalence of endometrial ployps in infertile patients with endometriosis, implying the special character of eutopic endometrium in endometriosis, which also impair embryo implantation [14].Animal studies support clinical data suggesting that endometriosis leads to implantation defects, again implicating the endometrium. Induction of endometriosis in animals demonstrates similar phenotypes to human disease [15][16][17].…”

Endometrial polyps: Pathogenesis, sequelae and treatment

“…60 Infertile patients with endometriosis were reported to have a higher prevalence of endometrial polyps, and these polyps were often combined with simple hyperplasia. 61…”

Mechanical versus unipolar hysteroscopic removal of endometrial polyp before intracytoplasmic sperm injection (ICSI)

“…Surprisingly, the majority of pregnancies happened naturally before the first IUI round. The systematic review by Zhang et al, (14) According to the researchers, the influence of endometrial polyps and hysteroscopic polypectomy on pregnancy outcomes following assisted reproductive technologies remains unknown. The current systematic study found that hysteroscopic removal of endometrial polyps less than 2 cm in diameter was linked to higher clinical pregnancy rates after IUI.…”