Coeliac disease in children with Down syndrome in Ireland

Alsaffar, Mohamed; Balfe, Joanne; McGrane, Fiona; Nadeem, Montasser; Quinn, Sean M.; Molloy, Eleanor J.

doi:10.1136/archdischild-2018-314846

Cited by 3 publications

(5 citation statements)

References 3 publications

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“…While a large meta‐analysis on the prevalence of celiac disease in individuals with DS found a slightly higher prevalence of celiac disease in studies of children only (6.6%; 95% CI: 4.7%–9.2%) than in studies with age mixed samples that also included adults (5.1%; 95% CI: 4.0%–6.4%), there was no pooled information on age of onset (Du et al, 2018). Similar to the increase we saw in active celiac disease in our 7–10 age group, previous clinic‐based cross‐sectional studies have shown a range of onset from 9 to 12 years (Alsaffar et al, 2019; Liu et al, 2020).…”

Section: Discussionsupporting

confidence: 89%

Co‐occurring conditions in Down syndrome: Findings from a clinical database

Baumer,

Hojlo,

Pawlowski

et al. 2023

American J of Med Genetics Pt C

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Individuals with Down syndrome (DS) experience a range of medical and neurodevelopmental conditions, necessitating systematic study of their occurrence and impact on neurodevelopmental outcomes. We describe the prevalence and relationships of medical, neurodevelopmental (ND), and mental health (MH) conditions in children with DS. We created a prospective clinical database of individuals with DS, integrated into the workflow of a specialty Down Syndrome Program at a specialty pediatric referral hospital. Conditions were collected through caregiver‐ and clinician report at clinical visits (N = 599). We calculated frequencies of medical, ND, and MH conditions and then assessed the relationship between medical, ND, and MH conditions using frequencies and comparative statistics. The most frequent co‐occurring conditions were vision (72.5%), ear/hearing (71.0%), gastrointestinal (61.3%), respiratory (45.6%), and feeding (33.6%) problems, with variation in frequency by age. ND and MH conditions were reported in one quarter, most commonly autism spectrum disorder and attention‐deficit/hyperactivity disorder. Those with ND and MH conditions had greater frequency of medical conditions, with highest rates of vision, ear/hearing, and gastrointestinal issues, and CHD. Systematically collected clinical data in a large cohort of children with DS reveals high prevalence of several co‐occurring medical, ND, and MH conditions. Clinical care requires an understanding of the complex relationship between medical conditions and neurodevelopment.

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Section: Discussionsupporting

confidence: 89%

Co‐occurring conditions in Down syndrome: Findings from a clinical database

Baumer,

Hojlo,

Pawlowski

et al. 2023

American J of Med Genetics Pt C

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“…Coeliac disease is estimated to have a prevalence of 5%‐7.5% in the DS population, a ten‐fold increase on the general population. It presents more insidiously with abdominal pain, bloating, constipation and behavioural difficulties.…”

Section: Cardiac Involvementmentioning

confidence: 99%

“…However, as constipation is a common complaint in children with DS and a single negative coeliac screen will not out‐rule coeliac disease for life, repeated screening has been recommend every 2‐3 years . Interestingly, by establishing HDL status and elimination of those who do not carry HLA‐DQ2 /8 which occur in 95% and 5% of patients with CD, respectively, will reduce the numbers needed to screen by 60% by identifying these high‐risk groups …”

Section: Cardiac Involvementmentioning

confidence: 99%

Multiorgan involvement and management in children with Down syndrome

et al. 2020

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“…Pacientes com SD possuem um risco maior de desenvolver doença celíaca do que a população em geral (5 a 10% contra 1%) (ALSAFFAR et al, 2019;IZZO et al, 2018).…”

Section: Síndrome De Downunclassified

“…Apesar de a European Society for Paediatric Gastroenterology, Hepatology and Nutrition e o National Institute for Health and Care Excellence recomendarem a triagem para doença celíaca em pacientes com síndrome de Down, ela não é feita corriqueiramente (ALSAFFAR et al, 2019). Assim, é possível que estudantes com SD não estejam recebendo alimentação escolar adequada porque seu estado nutricional não é monitorado de forma adequada.…”

Section: Síndrome De Downunclassified

Análise Da Composição Nutricional Do Cardápio Oferecido Em Uma Instituição De Ensino Filantrópica De Marechal Cândido Rondon- Pr

Alves

Garcia

2022

Intern. Journ. Env. Res. Res. Sci.

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Este trabalho teve por objetivo analisar o cardápio oferecido em uma instituição de ensino filantrópica do município de Marechal Cândido Rondon conforme as prerrogativas do PNAE e as necessidades nutricionais dos alunos, considerando o que a ciência diz até o momento sobre a alimentação de autistas e portadores da síndrome de Down. Foi realizado cálculo do valor nutricional do cardápio elaborado pela nutricionista do município e o executado pela instituição. Para a análise do valor nutricional, foi utilizado como parâmetro as recomendações do PNAE constantes na Resolução nº 26 de 2013 do FNDE. Para a análise realizada utilizou-se o programa Microsoft Excel e o Dietbox. Constataram-se dois problemas: a inadequação do cardápio em relação à faixa etária e aos macros e micronutrientes, conforme as necessidades do público atendido. Concluiu-se que instituições como a APAE necessitam da contratação de nutricionista para acompanhamento do seu público e a necessidade imediata de adequação dos cardápios visando atender as necessidades específicas de seus alunos conforme diagnosticado neste estudo.

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Coeliac disease in children with Down syndrome in Ireland

Cited by 3 publications

References 3 publications

Co‐occurring conditions in Down syndrome: Findings from a clinical database

Co‐occurring conditions in Down syndrome: Findings from a clinical database

Multiorgan involvement and management in children with Down syndrome

Análise Da Composição Nutricional Do Cardápio Oferecido Em Uma Instituição De Ensino Filantrópica De Marechal Cândido Rondon- Pr

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