Leptin and adiponectin levels in major depressive disorder: A systematic review and meta-analysis

Cao, Bing; Chen, Yan; Brietzke, Elisa; Cha, D.S.; Shaukat, Aisha; Pan, Zihang; Park, Caroline; Subramaniapillai, Mehala; Zuckerman, Hannah; Grant, Kiran; Mansur, Rodrigo B.; McIntyre, Roger S.

doi:10.1016/j.jad.2018.05.008

Cited by 63 publications

(35 citation statements)

References 72 publications

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“…Carvalho et al in their meta-analytic study published in 2014, found higher peripheral leptin levels in participants with mild to moderate major depressive disorder compared with controls, but no significant difference between controls and severely depressed patients [60]. However, a recent metaanalysis concluded that there is no difference in leptin levels between depressive subjects and controls [61]. Confounders such as age, gender-associated metabolic disturbances, medication history and clinical type of depressive disorders, might impact peripheral leptin levels, and thereby justify these inconsistent results [42,45].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an ongoing debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.

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Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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“…The relationship and the modulation of adiponectin in depressive disorders have been extensively studied. Specifically, several studies and a recent meta-analysis showed that MDD patients have low adiponectin levels [ 105 , 130 , 131 , 132 , 133 , 134 ], and that successfully antidepressant treatment increases its levels [ 135 ]. Interestingly, an inverse correlation between adiponectin levels and Hamilton Depression Rating Scale (HAM-D), indicating the depression symptoms severity at admission [ 130 , 132 , 136 ], or cumulative duration of depression [ 137 ] was identified.…”

Section: Adipokinesmentioning

confidence: 99%

“…Again, several confounding factors have to be taken into consideration. It is well known that ( a ) ethnic difference [ 140 , 141 ] between Asians and Europeans due to different body composition and metabolic profile [ 142 ], ( b ) matrix in which adiponectin is measured (plasma or serum) [ 134 ], ( c ) sex-dependent adiponectin levels [ 132 , 143 ], ( d ) body weight [ 137 ], ( e ) presence of metabolic syndrome [ 144 ], ( f ) onset of depressive event [ 107 ], and ( g ) the subtypes of depressive disorders [ 133 , 145 , 146 , 147 ] influence adiponectin levels.…”

Section: Adipokinesmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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“…Beyond acute emotion experiences, leptin and ghrelin may also be implicated in the etiology of chronic mood states. A recent meta‐analysis showed that individuals with major depression have lower levels of leptin (Cao et al, ), although findings were correlational, leaving the causal relation unclear. Similarly, leptin administration in rodents exerts antidepressant effects, wherein leptin performs as well as fluoxetine at reducing depressive symptoms (Liu et al, ).…”

Section: From Body To Mind: Leptin and Ghrelin May Contribute To Affementioning

confidence: 99%

The metabolic mind: A role for leptin and ghrelin in affect and social cognition

MacCormack

Muscatell

2019

Social & Personality Psych

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Leptin and ghrelin are metabolic hormones central to energy regulation in the body. Theories of allostasis suggest that metabolism could matter for more than just food intake and weight regulation but also ultimately for psychological processes, such as affect and social cognition. Allostasis is the process by which the brain monitors ongoing physiological states and, in turn, regulates physiology based on expectations about how a given situation will impact the self. Motivated by this allostatic perspective, we argue that leptin and ghrelin may be influenced by and even contribute to psychological processes such as affect and social cognition. Specifically, we review literature suggesting that leptin and ghrelin may be sensitive to social affective signals and related contexts (e.g., social status, and social threat vs. support), given that these signals and contexts may represent access to tangible physical and psychological resources that support allostasis and metabolic needs. We then review literature showing that leptin, ghrelin, and associated metabolic states may feed into the construction of social affective states and behaviors (e.g., emotion and risk taking), in order to motivate behaviors in line with allostatic needs. We close by offering guidelines for researchers interested in contributing to this emerging field and highlight opportunities for future research. We believe that leptin and ghrelin offer exciting new directions for social and affective scientists interested in linking the mind, brain, and body.

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Leptin and adiponectin levels in major depressive disorder: A systematic review and meta-analysis

Cited by 63 publications

References 72 publications

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Depression and Cardiovascular Disease: The Viewpoint of Platelets

The metabolic mind: A role for leptin and ghrelin in affect and social cognition

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