“…Although several clinical reports, including case reports and cohort studies, suggested the prothrombotic bent of hypoxia at HA, a few studies have instead supported its nonprothrombogenic nature. 10,18,19,21,25,26,[29][30][31][32][33][34] Thus, with the paucity of adequate information about any underlying connection between HA and a shift in coagulation mechanisms, we focused on the identification of factors that could ascertain the crucial role of HA in the aggravation of VTE events and, consequently, help to establish strategies to reduce these lifethreatening episodes at altitude. The present study evaluated 54 markers of parameters that have relevance to the development of thrombotic events under the influence of HA hypoxia as per our existing knowledge with support from the literature.…”