Neuroendocrine Factors and Head and Neck Squamous Cell Carcinoma: An Affair to Remember

Solomon, Iulia; Voiculescu, Vlad Mihai; Căruntu, Constantin; Lupu, Mihai; Popa, Adina; Ilie, Mihaela; Albulescu, Radu; Căruntu, Ana; Tănase, Cristiana; Constantin, Carolina; Neagu, Monica; Boda, Daniel

doi:10.1155/2018/9787831

Cited by 46 publications

(40 citation statements)

References 130 publications

(147 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brain-tumor patients. The VTE risk in patients with brain tumors is increased up to 60%, after surgery, with an incidence of 20-30% per year of survival (78)(79)(80). Although thromboprophylaxis is necessary, its use is still controversial, due to increased risk of intracranial hemorrhage demonstrated in some studies (81)(82)(83).…”

Section: Special Categoriesmentioning

confidence: 99%

Venous thromboembolism in cancer patients: Still looking for answers (Review)

Iorga

Bratu²,

Marcu³

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

Patients with cancer-associated venous thromboembolism (VTE) represent a real challenge in clinical practice. Patients with cancer have a greater risk both of VTE and bleeding. There are only a few studies regarding the therapeutic approach of VTE in patients with cancer, especially after cancer surgery, and on thromboprophylaxis during chemotherapy. Many of the anticoagulation therapy recommendations for cancer patients are extrapolated from trials that are not conducted in cancer cohorts. It is essential to assess the efficacy and safety of VTE prophylaxis in this particular subgroup, which bears higher risks both of VTE recurrence and major hemorrhagic events. The introduction of direct oral anticoagulants in everyday practice represented a major evolution of the anticoagulant treatment. Direct anticoagulants could represent a more appealing alternative to low-molecular-weight heparin in paraneoplastic venous thrombosis, due to the patient comfort, easy administration of the drug and emerging studies that prove similar efficacy and safety as the standard treatment. However, there is limited data on the treatment with direct oral anticoagulants in patients with paraneoplastic venous thromboembolism.

show abstract

Section: Special Categoriesmentioning

confidence: 99%

Venous thromboembolism in cancer patients: Still looking for answers (Review)

Iorga

Bratu²,

Marcu³

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Under ER stress, cancer cell increases COX2 expression via the NF-κB pathway, which plays an important anti-apoptotic role. Also, NF-κB pathway activation plays an important pro-inflammatory role through CHOP, and stimulates IL-8 synthesis as is the case in human epithelial cells (16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 97%

Modulation of the activity of certain genes involved in tumor cell metabolism in the presence of the cytotoxic peptides defensin and cathelicidin LL37

et al. 2019

View full text Add to dashboard Cite

It is common knowledge that some natural antimicrobial peptides also have a tumoricidal effect. We have shown that the peptides defensin and cathelicidin LL37 have cytostatic effects on human tumor cell lines HT29 (colorectal carcinoma) and A549 (alveolar carcinoma). In order to determine the modulating mechanism of these peptides we assessed the gene expression of the AKT, HIF-1α, XBP, NRF2, PERK, CHOP, BCL2, IRE1α and PI3K molecular targets involved in the survival, growth, proliferation and apoptosis pathways of tumor cells in the presence or absence of the studied peptides. Thus, this research enabled us to determine molecular markers and methods of assessment and monitoring of tumor cell cytotoxicity by high-performance molecular biology techniques. Defensin and cathelicidin LL37 activated tumor cell apoptosis, especially for the HT29, but also for A549 line, by increasing gene expression of CHOP and by lowering BCL2 gene expression. Oxidative stress determined the increase in gene expression of XBP, which directly influenced CHOP. The decrease in NRF2 gene expression highlighted the inhibition of cell proliferation, while the decrease in HIF1α gene expression evidenced the decrease in cell survival.

show abstract

“…Squamous cell and basal carcinomas are common malignancies that entail several pitfalls in their treatment such as inadequate skin penetration of chemotherapic drugs and depth-related difficulties in excision [177][178][179][180][181][182]. Systemic application of cannabinoids was proven effective in inducing apoptosis and tumor growth inhibition in vitro and in vivo on PDV.C57 epidermal tumor models.…”

Section: Non-melanoma Cancersmentioning

confidence: 99%

Cannabinoids in the Pathophysiology of Skin Inflammation

et al. 2020

Self Cite

View full text Add to dashboard Cite

Cannabinoids are increasingly-used substances in the treatment of chronic pain, some neuropsychiatric disorders and more recently, skin disorders with an inflammatory component. However, various studies cite conflicting results concerning the cellular mechanisms involved, while others suggest that cannabinoids may even exert pro-inflammatory behaviors. This paper aims to detail and clarify the complex workings of cannabinoids in the molecular setting of the main dermatological inflammatory diseases, and their interactions with other substances with emerging applications in the treatment of these conditions. Also, the potential role of cannabinoids as antitumoral drugs is explored in relation to the inflammatory component of skin cancer. In vivo and in vitro studies that employed either phyto-, endo-, or synthetic cannabinoids were considered in this paper. Cannabinoids are regarded with growing interest as eligible drugs in the treatment of skin inflammatory conditions, with potential anticancer effects, and the readiness in monitoring of effects and the facility of topical application may contribute to the growing support of the use of these substances. Despite the promising early results, further controlled human studies are required to establish the definitive role of these products in the pathophysiology of skin inflammation and their usefulness in the clinical setting.

show abstract

Neuroendocrine Factors and Head and Neck Squamous Cell Carcinoma: An Affair to Remember

Cited by 46 publications

References 130 publications

Venous thromboembolism in cancer patients: Still looking for answers (Review)

Venous thromboembolism in cancer patients: Still looking for answers (Review)

Modulation of the activity of certain genes involved in tumor cell metabolism in the presence of the cytotoxic peptides defensin and cathelicidin LL37

Cannabinoids in the Pathophysiology of Skin Inflammation

Contact Info

Product

Resources

About