A systematic review and meta-analysis of the association between vitamin A intake, serum vitamin A, and risk of liver cancer

Leelakanok, Nattawut; D’Cunha, Ronilda; Sutamtewagul, Grerk; Schweizer, Marin L.

doi:10.1177/0260106018777170

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…The unique phenomenon of pale leaves and lethal phenotype of the plants, which caused by inhibiting the desaturation process, have been usually used to evaluate the efficiency of genetic modification technology (Kaur et al, 2018). Meanwhile, carotenoids are also used as nutrient supplements (Leelakanok et al, 2018) and chemotherapy reagents (Noto et al, 1996). Genes involved in the carotenoid biosynthesis have been isolated and identified for enzymatic activities analysis (Norris et al, 1995;Liu et al, 2013;Brausemann et al, 2017), nutritional enhancements of food (Wurtzel et al, 2003) and genetical modification technology tools (Velasquez et al, 2009;Kaur et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Wang

et al. 2020

Front. Plant Sci.

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It is of great importance to combine stress tolerance and plant quality for breeding research. In this study, the role of phytoene desaturase (PDS), z-carotene desaturase (ZDS) and carotene isomerase (CRTISO) in the carotenoid biosynthesis are correlated and compared. The three genes were derived from Lycium chinenses and involved in the desaturation of tetraterpene. Their over-expression significantly increased carotenoid accumulation and enhanced photosynthesis and salt tolerance in transgenic tobacco. Up-regulation of almost all the genes involved in the carotenoid biosynthesis pathway and only significant down-regulation of lycopene e-cyclase (e-LCY) gene were detected in those transgenic plants. Under salt stress, proline content, and activities of catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) were significantly increased, whereas malonaldehyde (MDA) and hydrogen peroxide (H 2 O 2) accumulated less in the transgenic plants. The genes encoding ascorbate peroxidase (APX), CAT, POD, SOD, and pyrroline-5-carboxylate reductase (P5CR) were shown to responsive up-regulated significantly under the salt stress in the transgenic plants. This study indicated that LcPDS, LcZDS, and LcCRTISO have the potential to improve carotenoid content and salt tolerance in higher plant breeding.

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Section: Introductionmentioning

confidence: 99%

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Wang

et al. 2020

Front. Plant Sci.

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“…In experimental animal studies, long‐term administration of bromelain has exhibited an antihypertensive effect, indicating that bromelain supplements may reduce risk factors associated with cardiovascular diseases [33] . It is important to note that one of the main reasons for bromelain‘s anticancer property is its ability to inhibit blood platelet aggregation, which plays a crucial role in blood clotting [34] . Bromelain has been found to exhibit fibrinolytic activity, inhibit thrombus formation, and reduce platelet aggregation, thus impeding blood clotting [33] .…”

Section: Pharmacological Properties and Health Benefits Of Pineapple ...mentioning

confidence: 99%

Nutritional Composition and Therapeutic Potential of Pineapple Peel – A Comprehensive Review

Mehraj,

Das,

Feroz

et al. 2024

Chemistry & Biodiversity

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Pineapple (Ananas comosus), the succulent and vibrant tropical fruit, is a symbol of exoticism and sweetness. The pineapple peel, often considered as waste, has garnered attention for its potential applications. The pineapple peel is rich in essential nutrients, including calcium, potassium, vitamin C, carbohydrates, dietary fiber, and water, making it beneficial for the digestive system, weight management, and overall balanced nutrition. It contains significant amounts of sugars such as sucrose, glucose, and fructose, along with citric acid as the predominant organic acid. The peel also contains bromelain, a proteolytic enzyme known for its digestive properties. Studies have highlighted the pharmacological properties of pineapple peel, such as its potential anti‐parasitic effects, alleviation of constipation, and benefits for individuals with irritable bowel syndrome (IBS). Efforts are being made to promote the utilization of pineapple peel as a valuable resource rather than mere waste. Its applications range from the production of vinegar, alcohol, and citric acid to the development of various food products, including squash, syrup, jelly, and pickles. Further research and innovation are required to fully explore the potential of pineapple peel and establish sustainable practices for its utilization, contributing to waste reduction and the development of value‐added products.

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“…One systematic review and meta-analysis including 10 studies showed that vitamin A intakes were not associated with all-cause mortality among pre-diagnostic or post-diagnostic breast cancer patients ( 11 ). Another systematic review and meta-analysis of five studies found an inconclusive association between serum retinol and liver cancer ( 12 ). In a systematic review and meta-analysis of 11 studies on the risk association between vitamin A intake and cervical cancer, dietary total vitamin A intake and its components (retinol, β-carotene, and other carotenoids) were all inversely associated with cervical cancer ( 13 ).…”

Section: Health Outcomes Relevant For Nordic and Baltic Countriesmentioning

confidence: 99%

Vitamin A – a scoping review for Nordic nutrition Recommendations 2023

Olsen,

Lerner

2023

Food & Nutrition Research

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Vitamin A refers to a group of fat-soluble compounds with retinol activity, including all- trans retinol and pro-vitamin A carotenoids. Bioactive compounds include retinal and all- trans retinoic acid with important functions in vision, immune function, growth, and development. The literature search that was performed for the current scoping review yielded a total of seven publications relevant to setting the recommended daily intake for vitamin A. In total, six publications assessed the relationship of serum retinol and/or dietary vitamin A intake with fracture risk ( n = 2), cancer ( n = 3), and deficiency after bariatric surgery ( n = 1). One additional report by the European Food Safety Administration (EFSA) with updated average requirements was included. The outcomes-based systematic reviews and meta-analyses showed positive associations for vitamin A intake and serum retinol with risk of hip fracture. Weak or inconclusive associations were observed for cancer or obesity. One publication by EFSA with updated estimated average requirements and population reference intakes for dietary vitamin A intakes was published in 2015. The EFSA recommendations and estimated average requirements are based on a European reference population, with body weights derived from an assumed body mass index of 22, which might be too low and not representative of the Nordic and Baltic populations, and consequently resulting in lower estimated average requirements and recommendations. In conclusion, there were limited new outcomes-based data for vitamin A and health outcomes.

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A systematic review and meta-analysis of the association between vitamin A intake, serum vitamin A, and risk of liver cancer

Cited by 9 publications

References 46 publications

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Over-Expression of LcPDS, LcZDS, and LcCRTISO, Genes From Wolfberry for Carotenoid Biosynthesis, Enhanced Carotenoid Accumulation, and Salt Tolerance in Tobacco

Nutritional Composition and Therapeutic Potential of Pineapple Peel – A Comprehensive Review

Vitamin A – a scoping review for Nordic nutrition Recommendations 2023

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