Binding capacity of mannose-binding lectin (MBL) is associated with the severity of chronic Chagas cardiomyopathy

Azevedo, Elisa de Almeida Neves; Barreto, Silvana; Lima, Raul Emídio de; Teixeira, Romero Henrique; Diniz, George Tadeu Nunes; Oliveira, Wilson de; Cavalcanti, Maria da Glória Aureliano de Melo; Gomes, Yara M.; Moura, Patrícia; Morais, Clarice Neuenschwander Lins de

doi:10.1016/j.parint.2018.05.009

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2021

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“…In the severe form of Chagas disease, a greater binding capacity of MBL was observed, which could facilitate the internalization of T. cruzi in cardiomyocytes [ 26 ] Furthermore, MASP-2 deficiency does not represent an important mechanism against T. cruzi infection [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation

et al. 2021

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Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.

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Section: Introductionmentioning

confidence: 99%