Abietane diterpenoids from Lycopodium complanatum

New Diterpenes with Potential Antitumoral Activity Isolated from Plants in the Years 2017–2022

“…A plausible biogenetic pathway of abietane dite noid 146 was also proposed. Compound 146 inhibited the MSTO-211H cell line (hum lung cancer), with an IC50 value of 17.34 μM, using staurosporine as a positive control [88], salviyunnanone A 145 [89], and complan D 146 [90].…”

“…Phytochemical investigation of the lipophilic extract of the roots of Salvia leriifolia miaceae) resulted in the isolation of leriifolione 147, an unprecedented nor-abietane prenoid possessing a rare five-membered C-ring (Figure 60). A putative pathway fo [88], salviyunnanone A 145 [89], and complanatin D 146 [90].…”

“…Figure 59. Structures of 6-acetylfredericone B 144[88], salviyunnanone A 145[89], and complanatin D 146[90].…”

Palhinosides A–H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from Palhinhaea cernua

“…Palhinhaea cernua (family Lycopodiaceae) is widely distributed in southern and eastern China . The whole plants of P. cernua , called “Pu-Di-Wu-Gong” in Chinese, are traditionally used as an herbal medicine for relaxing tendons, healing contusions, and treating rheumatism. , Previous phytochemical investigations of P. cernua indicated the presence of flavones, neolignans, lycopodium alkaloids, and serratene-type triterpenoids. − As part of a search for structurally unique and biologically interesting natural products from plants of the family Lycopodiaceae, ,, the chemical components in the n -BuOH portion of the extract of P. cernua were investigated. As a result, eight new truxinate derivatives, palhinosides A–H ( 1 – 8 ), together with two known compounds, apigenin-7- O -(6″- O - p -coumaroyl)-β- d -glucopyranoside ( 9 ) and methyl 4-hydroxycinnamate ( 10 ), have been isolated.…”

“…9,10 Previous phytochemical investigations of P. cernua indicated the presence of flavones, 11 neolignans, 12 lycopodium alkaloids, and serratene-type triterpenoids. 13−20 As part of a search for structurally unique and biologically interesting natural products from plants of the family Lycopodiaceae, 12,21,22 the chemical components in the n-BuOH portion of the extract of P. cernua were investigated. As a result, eight new truxinate derivatives, palhinosides A−H (1−8), together with two known compounds, apigenin-7-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (9) and methyl 4-hydroxycinnamate (10), have been isolated.…”