Tobramycin mediated silver nanospheres/graphene oxide composite for synergistic therapy of bacterial infection

Ullah, Sadeeq; Ahmad, Aftab; Subhan, Fazli; Jan, Aminullah; Raza, Muslim; Khan, Arif Ullah; Rahman, Azizur; Khan, Usman Ali; Tariq, Muhammad; Yuan, Qipeng

doi:10.1016/j.jphotobiol.2018.05.009

Cited by 28 publications

(15 citation statements)

References 45 publications

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“…The obtained hybrid material showed superior antibacterial activity against multi‐drug resistant strains compared to pure Ag nanoparticles and tobramycin due to synergistic mechanisms, including direct membrane damage, ROS generation, [ 169 ] and inhibition of protein synthesis by aminoglycosides. [ 170 ] In another work, aminoglycosides were conjugated on the surface of graphite carbon nanofibers (GCNFs) via reductive amination and acylation, and the resultant aminoglycoside‐GCNF also showed an potent antibacterial activity by destabilizing bacteria membranes. [ 171 ]…”

Section: Aminoglycoside‐based Biomaterialsmentioning

confidence: 99%

Aminoglycoside‐Based Biomaterials: From Material Design to Antibacterial and Gene Delivery Applications

Yang

Cheng

et al. 2021

Adv Funct Materials

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Aminoglycosides are a family of naturally isolated or chemically semi‐synthesized antibiotics consisting of aminocyclitols with several amino and saccharide units. The unique molecule structures render aminoglycosides promising building blocks with high reactivity to perform various non‐covalent and covalent reactions, and they are further employed to rationally fabricate versatile materials, such as hydrogels, amphiphiles, hyperbranched polymers, biointerfaces, and nanoparticles. Despite aminoglycosides are widely used in clinics to treat bacterial infections, almost all the efforts are focused on molecular modifications to reduce their toxicities and overcome antibiotic resistance, while their actions as building blocks to construct biomaterials are scarcely discussed. In this feature article, the current progress on the rational design, emergent properties, and promising biological applications of aminoglycoside‐based biomaterials are summarized. It is believed that this paper may provide guidance to develop new biomaterials using natural functional molecules as building blocks, and start a new life of aminoglycosides from the view of materials science.

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Section: Aminoglycoside‐based Biomaterialsmentioning

confidence: 99%

Aminoglycoside‐Based Biomaterials: From Material Design to Antibacterial and Gene Delivery Applications

Yang

Cheng

et al. 2021

Adv Funct Materials

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“…In general, Ag-LTF was non-cytotoxic for up to 24 h of exposure, even at the highest concentration tested. A study by Ullah et al 37 also demonstrated that AgNPs-GO composites decorated with tobramycin were tolerated by human embryonic kidney cells (HEK 293 cell line) up to 160 mg mL À1 . Similar ndings were observed for biosynthesized AgGO using a ower extract of Legistromia speciosa (L.) Pers on HEK 293 cell line.…”

Section: Cytotoxicity Effects and Cell Migrationmentioning

confidence: 97%

“…A more recent study showed that GO caused a minor damage to bacteria, owing to its negative charge that could not interact well with the bacterial membrane. 37 However, other contrasting ndings reported that GO could inhibit bacteria in a concentrationdependent manner. [38][39][40] These contradictory ndings may be attributable to the different physiochemical characteristics for each particular nanoparticle formulation.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

et al. 2020

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“…The research of the mechanism by which TOB-GO-Ag composite exerted a synergistic antibacterial effect via destroying the integrity of the cell wall and promoting the entry of Ag + ion and GO into cells, which finally destroyed bacteria through oxidative stress mechanism. Meanwhile tobramycin in the prepared composites could also help affect bacterial growth by inhibiting protein synthesis ( Ullah et al, 2018 ).…”

Section: Strategies To Reverse Bacterial Resistance To Aminoglycoside...mentioning

confidence: 99%

Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics

et al. 2022

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After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial infections and bacterial resistance to AGAs is increasing. The bacterial resistance to AGAs is owed to aminoglycoside modifying enzyme modification, active efflux pump gene overexpression and 16S rRNA ribosomal subunit methylation, leading to modification of AGAs’ structures and decreased concentration of drugs within bacteria. As AGAs’s side effects and bacterial resistance, the development of AGAs is time-consuming and difficult. Because bacterial resistance may occur in a short time after application in clinical practice, it was found that the antibacterial effect of the combination was not only better than that of AGAs alone but also reduce the dosage of antibiotics, thereby reducing the occurrence of side effects. This article reviews the clinical use of AGAs, the antibacterial mechanisms, the molecular mechanisms of bacterial resistance, and especially focuses a recent development of the combination of AGAs with other drugs to exert a synergistic antibacterial effect to provide a new strategy to overcome bacterial resistance to AGAs.

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Tobramycin mediated silver nanospheres/graphene oxide composite for synergistic therapy of bacterial infection

Cited by 28 publications

References 45 publications

Aminoglycoside‐Based Biomaterials: From Material Design to Antibacterial and Gene Delivery Applications

Aminoglycoside‐Based Biomaterials: From Material Design to Antibacterial and Gene Delivery Applications

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan

Antibiotic Combination Therapy: A Strategy to Overcome Bacterial Resistance to Aminoglycoside Antibiotics

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