Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants

Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps

“…, in gray matter structure(3,5,(67)(68)(69), during symptom provocation(63,70,71), and across multiple cognitive and decision-making tasks in OCD(3-5, 72, 73). Moreover, many resting-state, structural and functional abnormalities within these regions are shared with unaffected relatives of patients with OCD (26,64,65,68,71,74,75), and are OCD-specific relative to disorders such as attention deficit/hyperactivity disorder and anxiety disorders(3,42,54,72,73). The current findings provide further evidence for cross-modal abnormalities in cinguloopercular and orbito-striato-thalamic brain networks in OCD(3,6), which may be endophenotypes for the disorder(68).…”

Effects of Bergen 4-Day Treatment on Resting-State Graph Features in Obsessive-Compulsive Disorder

“…In Paper II we added 19 unaffected siblings of the OCD group. We found that the siblings showed low distress levels during provocation (lower than patients and similar to healthy controls), suggesting that only patients were excessively distressed by the fear and OCD-related stimuli (Thorsen et al, 2019). The siblings showed no significant difference in right amygdala activation during OCD-related provocation, relative to patients or healthy controls, while OCD patients showed an altered shape and timing of the BOLD response in this area.…”

“…Interestingly, only siblings showed hyperactivation of the left temporo-occipital cortex during regulation of OCD-related stimuli. Siblings alone also showed greater dmPFC-amygdala connectivity compared to OCD patients during regulation of OCD-related stimuli (Thorsen et al, 2019).…”

“…In summary, more activation in the fronto-limbic circuit during provocation, less dlPFC activation during fear-related regulation and more dmPFC activation during OCD-related regulation seem to be characterize patients but not siblings. This suggests that emotion provocation and regulation does not mediate the familial risk of OCD (Thorsen et al, 2019).…”

Experiências adversas na infância e adolescência, mediadores e transtorno obsessivo-compulsivo: um estudo com pacientes, irmãos e controles

“…Assim como já há estudos em amostras de pares de irmãos e controles que comparam as diferenças neurobiológicas, por meio de diferentes técnicas de neuroimagem, correlacionando as EAIA e diferenças cerebrais e como os irmãos sem TOC são diferentes neurobiologicamente tanto dos pacientes quanto dos controles, assim como as diferenças quanto a processamento e regulação de emoções. A presente amostra possui também dados de neuroimagem já coletados, o que abre espaço para estudos futuros que invistam no estudo dessas relações (63,114). Do ponto de vista dos tratamentos psicoterápicos, os dados do presente estudo lançam luz sobre a importância de se estudar processos como as experiências dissociativas, a resiliência e a esquiva experiencial impactam a resposta ao tratamento.…”