Risk factors for ruptured intracranial aneurysms

Wang, Guang-Xian; Zhang, Dong; Wang, Zhiping; Yang, Liuqing; Yang, Hua; Li, Wen

doi:10.4103/ijmr.ijmr_1665_15

Cited by 33 publications

(6 citation statements)

References 25 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, the sample size was relatively small, which may have contributed to false associations due to limited statistical power; therefore, it is important to use larger studies to further verify the association between the LOX family genes and aSAH. Second, we could not modify the morphological factors for multivariate analysis due to patients with two or more aneurysms in the multiple IA group; however, considering irregular aneurysms are more likely to rupture than regular aneurysms, and irregular aneurysms were more common in the ruptured group [41,42]. Hence, we suggest the univariate analysis results of multiple IA ruptures may provide a reference for multiple IA etiological research.…”

Section: Discussionmentioning

confidence: 99%

Lysyl oxidase family genes polymorphisms and risk of aneurysmal subarachnoid hemorrhage: A case control study

Dong¹,

Luo²,

Li³

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction: aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease caused by intracranial aneurysm (IA) rupture. Lysyl oxidase (LOX) family genes (LOX-like [LOXL] 1–4) have roles in collagen cross-linking in the extracellular matrix and may be associated with IA rupture. We aimed to explore the association between LOX polymorphisms and the risk of aSAH. Methods This case-control study included two cohorts: 133 and 115 single ruptured and unruptured IA patients, and 65 and 71 multiple ruptured and unruptured IAs patients, respectively. Genotyping of 27 single nucleotide polymorphisms (SNPs) in LOX was performed. Logistic regression analysis was performed to calculate the odds ratios (OR) and 95% confidence intervals (CI) of the SNPs of LOX and risk of aSAH. Results LOX rs180044 and LOXL4 rs3793692 were positively associated with the risk of single IA rupture in the recessive model (OR = 5.66, 2.06; 95% CI = 1.22–26.24, 1.11–3.82, respectively) and LOX rs10519694 demonstrated a protective effect on single IA rupture (dominant model: OR = 0.42, 95% CI = 0.21–0.83; recessive model: OR = 0.16, 95% CI = 0.04–0.65; additive model: OR = 0.46, 95% CI = 0.28–0.78). LOXL1 rs2165241, LOXL2 rs1063582, and LOXL3 rs17010021 demonstrated risk effects on multiple IAs rupture. LOXL3 rs17010022 showed a protective effect on multiple IAs rupture (dominant model: OR = 0.41, 95% CI = 0.21–0.82; additive model: OR = 0.51, 95% CI = 0.30–0.85). Discussion LOX and LOXL4 may be susceptible to single IA rupture, whereas LOXL1-3 may have a role in susceptibility to multiple IAs rupture in the Chinese population, suggesting LOX family genes may associated with aSAH.

show abstract

Section: Discussionmentioning

confidence: 99%

Lysyl oxidase family genes polymorphisms and risk of aneurysmal subarachnoid hemorrhage: A case control study

Dong¹,

Luo²,

Li³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Irregular morphology of aneurysm has been widely recognized as a risk factor for rupture. 19 20 However, the relationship between IPR and the shape of aneurysm is still controversial. Li et al found that irregular morphology was an independent predictor of IPR in patients with unruptured cerebral aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Intraprocedural Rerupture during Embolization of Ruptured Intracranial Aneurysms

Wang

Chen

2020

J Korean Med Sci

View full text Add to dashboard Cite

Background Intraprocedural rupture (IPR) is a devastating complication in endovascular treatment of ruptured intracranial aneurysms, but its risk factors have not been fully assessed. This study was performed to explore the risk factors for IPR during embolization of ruptured cerebral aneurysms. Methods A total of 1,494 patients with ruptured intracranial aneurysms who underwent endovascular interventional embolization were enrolled. Clinical characteristics were collected for each patient. Univariate and multivariate logistic regression analysis was employed to identify the factors independently associated with IPR. A receiver operating characteristic (ROC) curve analysis was performed to determine the cutoff values of continuous variables predicting IPR. Results Forty-one patients suffered from IPR (2.7%). Multivariate logistic regression analysis indicated that aneurysm size (odds ratio [OR], 0.819; 95% confidence interval [CI], 0.732–0.916), aneurysms with irregular morphology (OR, 2.162; 95% CI, 1.143–4.091), time from symptom onset to intervention (OR, 1.615; 95% CI, 1.207–2.161), and vasospasm during embolization (OR, 2.021; 95% CI, 1.038–3.934) were the independent risk factors of IPR. ROC curve analysis showed that the area under the curve for aneurysm size and time from onset to intervention were 0.697 (cutoff value, 3.4 mm; sensitivity, 78.8%; and specificity, 53.7%) and 0.659 (cutoff value, 2 days; sensitivity, 78.0%; and specificity, 45.2%), respectively. Conclusion Aneurysms with irregular morphology, aneurysms ≤ 3.4 mm in diameter, time from onset to intervention > 2 days and cerebral vasospasm during embolization are independent risk factors for IPR during coil embolization of ruptured aneurysms. More attention should be paid to the factors increasing the risk of IPR in patients with ruptured aneurysms so as to minimize this complication.

show abstract

“…About 2% to 3% of the general population carries an unruptured IA, whereas about 30% of the IA patients suffer from several aneurysms. [22][23][24][25] With the increased application of noninvasive imaging, the detection rate of these IA has gradually increased. Upon the diagnosis of an unruptured aneurysm, an evaluation will be carried out to assess the likelihood of aneurysm rupture.…”

Section: Discussionmentioning

confidence: 99%

A functional polymorphism in the promoter region of miR‐155 predicts the risk of intracranial hemorrhage caused by rupture intracranial aneurysm

Yang

Peng

Pang

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Background This study aimed to study the effect and underlying molecular mechanisms of single‐nucleotide polymorphism (SNP) rs767649 during the pathogenesis of intracranial aneurysm (IA) rupture. Method Real‐time PCR and Western blot analysis were performed to detect the differentiated expression of miR‐155 and matrix metalloproteinase‐2 (MMP‐2) among different sample groups. Computational analysis and luciferase assay were conducted to study the effect of SNP rs767649 on the expression of miR‐155 as well as the regulatory relationship between miR‐155 and MMP‐2. Results In unruptured IA samples, the expression of miR‐155 was upregulated while the expression of MMP‐2 was downregulated compared with the ruptured IA samples. Similarly, the expression of miR‐155 was upregulated while the expression of MMP‐2 was downregulated in samples genotyped as AA/AT compared with samples genotyped as TT. In addition, compared with the negative controls, the luciferase activities of cells treated with rs767649A and rs767649T were both elevated with rs767649A‐transfected cells expressing the highest luciferase activity. Furthermore, a negative relationship was established between miR‐155 and MMP‐2 by measuring the luciferase activity of cells cotransfected with miR‐155 and the wild‐type 3′‐untranslated region of MMP‐2. Conclusion The results of this study showed that the SNP rs767649 in the promoter of miR‐155 could reduce the transcription activity of miR‐155, while poorly expressed miR‐155 could increase the incidence of IA rupture by increasing the expression of MMP‐2, especially in subjects carrying the TT genotype of SNP rs767649.

show abstract

Risk factors for ruptured intracranial aneurysms

Cited by 33 publications

References 25 publications

Lysyl oxidase family genes polymorphisms and risk of aneurysmal subarachnoid hemorrhage: A case control study

Lysyl oxidase family genes polymorphisms and risk of aneurysmal subarachnoid hemorrhage: A case control study

Risk Factors for Intraprocedural Rerupture during Embolization of Ruptured Intracranial Aneurysms

A functional polymorphism in the promoter region of miR‐155 predicts the risk of intracranial hemorrhage caused by rupture intracranial aneurysm

Contact Info

Product

Resources

About