XRCC2 Polymorphisms and Environmental Factors Predict High Risk of Colorectal Cancer

Wang, Lijie; Ma, Junxun; Yang, Bo; Jing, Fangfang; Hu, Yi

doi:10.12659/msm.904935

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…The differential expression of CHEK1, XRCC2, DDIAS and NEIL3 were related to DNA damage and repair [89][90][91][92]. XRCC2 polymorphisms and its protein were associated with susceptibility of colorectal cancer [93,94]. CHK1 inhibitors are promising in chemo-and radio-sensitization [95].…”

Section: Discussionmentioning

confidence: 99%

Weighted Gene Coexpression Network Analysis of Key Genes Controlling Cancer Stem Cell Characteristics by Mrnasi in Colon Adenocarcinoma

Zhang

Yin

Tong

2021

Preprint

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Background: Cancer stem cells are hidden tumor cells with the potential for self-renewal and multi-differentiation, which are the principal cause of tumor heterogeneity, metastasis and drug resistance. However, the key genes that maintain cell stemness of colon adenocarcinoma (COAD) are still unknown. Our study was designed to identify key genes associated with the stemness of COAD cell. Methods: RNA sequencing data and clinical information were downloaded from The Cancer Genome Atlas (TCGA). Weighted gene coexpression network analysis (WGCNA) was used to recognize key genes based on mRNAsi. Next, the gene expression data downloaded from Gene Expression Omnibus (GEO), Oncomine, and Gene Expression Profiling Integrative Analysis (GEPIA) were used to demonstrate the expression of key genes.Results: The mRNAsi score of COAD tissue was obviously superior than that of normal tissue. N stages, M stages and overall survival were highly related to mRNAsi. WGCNA showed that the green module was positively related to mRNAsi. We obtained 27 genes closely related to each other at the transcriptional and protein levels. The main biological functions of key genes were organelle fission, chromosomal region, and protein serine/threonine kinase activity. The enriched signaling pathway were cell cycle, progesterone−mediated oocyte maturation, human T−cell leukemia virus 1 infection, oocyte meiosis, DNA replication, cellular senescence, viral carcinogenesis, and p53 signaling pathway. The key genes were highly expressed in COAD and various cancers, which was validated multiple databases. Conclusions: 27 key genes were well correlated with maintaining stemness of COAD, which were significantly related to cell cycle events. The key genes may be therapeutic targets for inhibiting the properties of COAD stem cells.

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Section: Discussionmentioning

confidence: 99%

Weighted Gene Coexpression Network Analysis of Key Genes Controlling Cancer Stem Cell Characteristics by Mrnasi in Colon Adenocarcinoma

Zhang

Yin

Tong

2021

Preprint

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“…With increasing progress in molecular biology, the study of the etiology of CRC has advanced from environmental factors to environmental-genetic interactions, and gradually encroached on analyses at molecular level [20,21]. By investigating the molecular mechanisms behind the formation of tumors, a clearer understanding of the relationship among environment, genetics, genes, and CRC has been established.…”

Section: Discussionmentioning

confidence: 99%

APC gene 3′UTR SNPs and interactions with environmental factors are correlated with risk of colorectal cancer in Chinese Han population

Ying¹,

Wei²,

Mei

et al. 2020

Bioscience Reports

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Objective: To study the correlation between adenomatous polyposis coli (APC) gene 3′ untranslated region (UTR) single nucleotide polymorphisms (SNPs) and their interactions with environmental factors and the risk of colorectal cancer (CRC) in a Chinese Han population. Methods: Genotypes of APC gene 3′UTR rs1804197, rs41116, rs448475, and rs397768 loci in 340 Chinese Han patients with CRC and 340 healthy controls were analyzed. All patients with CRC were analyzed for progression-free survival (PFS) during a 3-year follow-up. Results: The risk of CRC in subjects carrying the APC gene rs1804197 A allele was 2.95-times higher than for the C allele carriers. The interactions of the rs1804197 SNP with body mass index (BMI) and smoking were associated with the risk of CRC. The risk of CRC in the APC gene rs397768 G allele carriers was 1.68-times higher than in the A allele carriers. The interaction between the rs397768 locus SNP and gender was also associated with the risk of CRC. The 3-year PFS of patients with APC gene rs1804197 AA genotype, CA genotype, and CC genotype CRC decreased in this order, with significant difference. In addition, the 3-year PFS of rs397768 locus GG genotype, AG genotype, and AA genotype CRC patients decreased in this order, and the difference was significant. Conclusion: The rs1804197 locus in the 3′UTR region of the APC gene and its interactions with BMI and smoking are associated with the risk of CRC in a Chinese Han population. In addition, the interaction between rs397768 locus SNP and gender is related to the risk of CRC.

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“…The XPD protein is a kind of protein that is absolutely necessary for the 5′-3′ helicase enzyme to have a role in the DNA repair pathway [ 11 ]. Polymorphism −751 in the XPD gene has been associated with a lower DNA repair capacity and a different kind of carcinogenesis [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study

Öztürk¹,

Pehlıvan

Balat

et al. 2018

Med Sci Monit Basic Res

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BackgroundIn this study, we aimed to evaluate the association between endometrial hyperplasia and DNA repair gene (XPD, XRCC4, and XRCC1) polymorphisms.Material/MethodsThere were 114 cases enrolled in the study in 4 groups: simple endometrial hyperplasia (SH) (Group 1), complex endometrial hyperplasia without atypia (CH) (Group 2), complex atypical endometrial hyperplasia (CAH) (Group 3), and normal endometrium (NE) (Group 4). Of these cases, 37 cases had SH, 36 cases had CH, 16 cases had CAH, and 25 cases had NE. To evaluate an association between atypia and DNA repair genes, we consider a group that included both SH and CH, the endometrial hyperplasia without atypia cases (Group 5). Genomic DNA was isolated from paraffin-embedded endometrial tissue collected from the Pathology Department of Gaziantep University Medical School. Polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) method was used for evaluating of XPD (−751), XRCC4 (−1394 and a variable number of tandem repeats in intron 3), and XRCC1 (−399) genes.ResultsWe observed a notable distinction in patients having endometrial hyperplasia without atypia (the SH+CH group) and the CAH group in terms of XPD (−751) gene polymorphisms. A notable contrast was observed in patients with endometrial hyperplasia without atypia (the SH+CH group) and the NE group in terms of XRCC4 (VNTR intron 3) polymorphisms (P=0.026, P=0.018, respectively).ConclusionsIt was evident the DNA repair gene XPD and XRCC4 polymorphisms had a role in the pathophysiology of endometrial hyperplasia.

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XRCC2 Polymorphisms and Environmental Factors Predict High Risk of Colorectal Cancer

Cited by 4 publications

References 33 publications

Weighted Gene Coexpression Network Analysis of Key Genes Controlling Cancer Stem Cell Characteristics by Mrnasi in Colon Adenocarcinoma

Weighted Gene Coexpression Network Analysis of Key Genes Controlling Cancer Stem Cell Characteristics by Mrnasi in Colon Adenocarcinoma

APC gene 3′UTR SNPs and interactions with environmental factors are correlated with risk of colorectal cancer in Chinese Han population

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study

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