One-pot synthesis of a metal–organic framework-based drug carrier for intelligent glucose-responsive insulin delivery

Duan, Yan; Ye, Fanggui; Huang, Yuanlin; Qin, Yuemei; He, Caimei; Zhao, Shulin

doi:10.1039/c8cc02708k

Cited by 119 publications

(82 citation statements)

References 32 publications

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“…Usually, insulin and GOx were co-incorporated in ZIF-8, after the dissolution of ZIF-8 in the acidic microenvironment caused by high glucose level, insulin would be released. [76][77][78] By further encapsulation of catalase, a H 2 O 2scavanger, within ZIF-8, the potential cytotoxicity of the GOx-generated H 2 O 2 could be eliminated due to the consumption of H 2 O 2 catalyzed by catalases. [54] Therefore, the cascade reaction of GOx/catalases within MOF enabled a smart glucose-responsive carrier without significant cytotoxicity.…”

Section: Catalytic Nanomedicinementioning

confidence: 99%

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Liang

2020

The Chemical Record

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Multi-enzyme cascade reactions are indispensable in biotechnology and many industrial (bio)chemical processes. However, most natural enzymes have poor stability and reusability, and tend to inactivate in toxic media or high temperature, which significantly limit their broader applications. Metal-organic frameworks (MOFs) are promising candidates for enzymes immobilization to produce nanocomposite structures that not only could shield the enzymes from harsh environments, but also facilitate selective diffusion of substrates and intermediates to the reactive site via their tailorable and ordered pore network. Multi-enzyme cascade reactions in MOFs have recently attracted considerable attention. This Personal Account discusses the different strategies for multi-enzyme-MOF interfaces and their cutting-edge applications from biosensing and catalytic nanomedicine to artificial/hybrid cells. At last, we provide a critical evaluation and future prospects to outline future research directions.

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Section: Catalytic Nanomedicinementioning

confidence: 99%

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Liang

2020

The Chemical Record

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“…For drug adsorption, delivery and other biomedical applications, cell cytotoxicity is one of the main important factors which should be considered when developing new materials . Therefore, before using these nanoparticles for drug adsorption, the cellular toxicity experiments were performed on the HFF2 cell line with different concentrations of various MOFs.…”

Section: Resultsmentioning

confidence: 99%

Zr‐Based MOFs with High Drug Loading for Adsorption Removal of Anti‐Cancer Drugs: A Potential Drug Storage

Molavi

Moghimi

Taheri

2020

Applied Organom Chemis

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A robust and highly water stable series of UiO‐66‐drived MOFs including UiO‐66‐NH2, glycidyl methacrylate functionalized UiO‐66‐NH2 (UiO‐66‐GMA) and ethylenediamine functionalized UiO‐66‐NH2 (UiO‐66‐EDA) were synthesized solvothermally and studied their adsorption performances toward two anti‐cancer drugs, methotrexate (MTX) and curcumin (CUR) in the case of overdose. It was found that functionalizing the surface of UiO‐66‐NH2 nanoparticles with different functional groups remarkably changes the adsorption capacity and the ideal adsorption selectivity of MTX over CUR. Particularly, the UiO‐66‐EDA exhibited the highest adsorption capacities for both drugs, 540.78 and 423.85 mg/g for MTX and CUR, respectively, because of the strong interaction between drug molecules and adsorbent via hydrogen bonding due to the existence of different polar functional groups. The kinetics of drugs adsorption was investigated by three well‐known kinetic models, which the output indicates that the adsorption of both drugs onto the synthesized MOFs follow the pseudo‐second‐order model. Moreover, it was found that the equilibrium adsorption results were well fitted with the Langmuir isotherm models, revealing that the adsorption of both drugs onto the synthesized MOFs is a monolayer adsorption process. Further investigation illustrated that the synthesized MOFs could be easily activated and reused after four successive adsorption–desorption cycles. The output of the present work is of main important for biomedical and environmental applications of MOFs as an outstanding adsorbent for adsorption removal of hazardous drugs from contaminated aqueous solutions.

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“…In fact, using this technique has expanded the possible applications of enzymes in the fields of biosensing, [29] biocatalysis, [30] separation, [31] microreactors, [32] and nanocatalytic medicine. [33] However, this immobilization technique is still in its infancy, and continuous challenges for further improvements remain: 1) most MOFs are microporous structures that are not capable of accommodating enzymes in their cavities. It is anticipated that seeking new approaches to construct mesoporous MOFs or tailoring the intrinsic micropores into mesopores through an appropriate method (template-directed or defect-engineering methods etc.)…”

Section: Discussionmentioning

confidence: 99%

Metal‐Organic Frameworks: A New Platform for Enzyme Immobilization

Kou

Shen

et al. 2020

ChemBioChem

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Metal‐organic frameworks (MOFs) with attractive properties such as high surface area, tunable porosity, designable functionality and excellent stability, have aroused great interest from researchers as the matrices for enzyme immobilization. Recently, several efficient strategies including surface immobilization, post‐synthetic infiltration and in situ encapsulation have been explored. MOF‐immobilized enzymes, named enzymes@MOFs, show remarkably enhanced stability and recyclability, accelerating cell‐free biocatalysis in diverse applications. This concept will impart the typical strategies for enzyme immobilization with MOFs, and their potential applications.

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One-pot synthesis of a metal–organic framework-based drug carrier for intelligent glucose-responsive insulin delivery

Cited by 119 publications

References 32 publications

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Zr‐Based MOFs with High Drug Loading for Adsorption Removal of Anti‐Cancer Drugs: A Potential Drug Storage

Metal‐Organic Frameworks: A New Platform for Enzyme Immobilization

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