<scp>H</scp>eterogeneity in risk of prostate cancer: <scp>A</scp><scp>S</scp>wedish population‐based cohort study of competing risks and <scp>T</scp>ype 2 diabetes mellitus

Häggström, Christel; Hemelrijck, Mieke Van; Garmo, Hans; Robinson, David; Stattin, P.; Rowley, Mark; Coolen, A. C. C.; Holmberg, Lars

doi:10.1002/ijc.31587

Cited by 12 publications

(8 citation statements)

References 45 publications

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“…[7][8][9] For example, the presence and absence of an intrasellar pituitary gland can help distinguish suprasellar and intrasellar tumors, i. e. pituitary tumors. 10,11 However, suprasellar tumors often invade into the sellar and compress the pituitary to move backward, and the imaging appearance is crescent. Enhanced MRI usually shows the characteristic signs of sellar region tumors, such as "meningioma tail sign", which is the gold standard for the diagnosis of meningioma.…”

Section: Discussionmentioning

confidence: 99%

Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region

Zhang¹,

Zhang²,

Zhao

2021

Pak J Med Sci

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Objective: The paper applies spatial fuzzy clustering algorithm to explore the role and value of neuroendoscopic assisted technology in the operation of tumors in the saddle region, and analyze the MRI image characteristics of tumors in the saddle region. Methods: The clinical data of 63 patients from our hospital who underwent neuroendoscopic assisted microscopy to remove tumors in the saddle area from 2017 to 2019 (neuroendoscopy-assisted group) were collected. Seventy six patients who occupied the saddle area by microscopic resection only in the same period (Simple microscope group) clinical data. By comparing the patient’s tumor resection rate, postoperative complication rate and postoperative recurrence rate, the surgical effect was evaluated. Results: The total resection rates of the tumors in the neuroendoscopy-assisted group and the microscope-only group were 95.24% (60/63) and 80.26% (61/76). The incidence of postoperative vasospasm was 3.17% (2/63) and 13.16% (10/76), the incidence of nerve injury was 0 (0/63) and 6.58% (5/76), the difference was statistically significant (P <0.05). There was no significant difference in the incidence of postoperative infection, cerebrospinal fluid leakage and postoperative recurrence rate between the two groups (P> 0.05). Conclusion: Neuroendoscopy-assisted microscopy-based removal of the saddle area occupying space based on spatial fuzzy clustering algorithm can increase the total tumor resection rate and reduce the incidence of complications. doi: https://doi.org/10.12669/pjms.37.6-WIT.4850 How to cite this:Zhang P, Zhang L, Zhao R. Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region. Pak J Med Sci. 2021;37(6):1600-1604. doi: https://doi.org/10.12669/pjms.37.6-WIT.4850 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region

Zhang¹,

Zhang²,

Zhao

2021

Pak J Med Sci

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“…The impact of T2D on PCa is complex [ 7 ], and the relationship is influenced by numerous factors that are difficult to assess individually [ 12 ]. While a large number of studies have reported a lower PCa risk in patients with T2D [ 13 ], they are characterized by more advanced PCa than patients with normal glucose metabolism [ 8 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes

Frankó

Berti

Hennenlotter

et al. 2020

JPM

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Aldo-keto reductase family 1 (AKR1) enzymes play a crucial role in diabetic complications. Since type 2 diabetes (T2D) is associated with cancer progression, we investigated the impact of diabetes on AKR1 gene expression in the context of prostate cancer (PCa) development. In this study, we analyzed benign (BEN) prostate and PCa tissue of patients with and without T2D. Furthermore, to replicate hyperglycemia in vitro, we treated the prostate adenocarcinoma cell line PC3 with increasing glucose concentrations. Gene expression was quantified using real-time qPCR. In the prostate tissue of patients with T2D, AKR1C1 and AKR1C2 transcripts were higher compared to samples of patients without diabetes. In PC3 cells, high glucose treatment induced the gene expression levels of AKR1C1, C2, and C3. Furthermore, both in human tissue and in PC3 cells, the transcript levels of AKR1C1, C2, and C3 showed positive associations with oncogenes, which are involved in proliferation processes and HIF1α and NFκB pathways. These results indicate that in the prostate glands of patients with T2D, hyperglycemia could play a pivotal role by inducing the expression of AKR1C1, C2, and C3. The higher transcript level of AKR1C was furthermore associated with upregulated HIF1α and NFκB pathways, which are major drivers of PCa carcinogenesis.

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“…Further investigation of these individuals can therefore help to uncover indicators for either preventative or therapeutic measures. 21 Therefore, replica analysis and further AI techniques may be useful for prediction models in the real world settings.…”

Section: Artificial Intelligence – Is It Worth the Hype?mentioning

confidence: 99%

Real World Data Studies of Antineoplastic Drugs: How Can They Be Improved to Steer Everyday Use in the Clinic?

George,

Russell,

Rigg

et al. 2023

POR

Self Cite

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There is a growing interest in real world evidence when developing antineoplastic drugs owing to the shorter length of time and low costs compared to randomised controlled trials. External validity of studies in the regulatory phase can be enhanced by complementing randomised controlled trials with real world evidence. Furthermore, the use of real world evidence ensures the inclusion of patients often excluded from randomised controlled trials such as the elderly, certain ethnicities or those from certain geographical areas. This review explores approaches in which real world data may be integrated with randomised controlled trials. One approach is by using big data, especially when investigating drugs in the antineoplastic setting. This can even inform artificial intelligence thus ensuring faster and more precise diagnosis and treatment decisions. Pragmatic trials also offer an approach to examine the effectiveness of novel antineoplastic drugs without evading the benefits of randomised controlled trials. A well-designed pragmatic trial would yield results with high external validity by employing a simple study design with a large sample size and diverse settings. Although randomised controlled trials can determine efficacy of antineoplastic drugs, effectiveness in the real world may differ. The need for pragmatic trials to help guide healthcare decision-making led to the development of trials within cohorts (TWICs). TWICs make use of cohorts to conduct multiple randomised controlled trials while maintaining characteristics of real world data in routine clinical practice. Although real world data is often affected by incomplete data and biases such as selection and unmeasured biases, the use of big data and pragmatic approaches can improve the use of real world data in the development of antineoplastic drugs that can in turn steer decision-making in clinical practice.

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Heterogeneity in risk of prostate cancer: ASwedish population‐based cohort study of competing risks and Type 2 diabetes mellitus

Cited by 12 publications

References 45 publications

Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region

Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region

Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes

Real World Data Studies of Antineoplastic Drugs: How Can They Be Improved to Steer Everyday Use in the Clinic?

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