Gynaecologic cancer surgery and preservation of fertility

Bentivegna, Enrica; Maulard, Amandine; Miailhe, G.; Gouy, Sébastien; Morice, Philippe

doi:10.1016/j.jviscsurg.2018.03.001

Cited by 11 publications

(10 citation statements)

References 36 publications

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“…Gynecological cancers such as cervical cancer, endometrial carcinoma, ovarian cancer, and gestational choriocarcinoma are the most common malignant diseases. They are treated by different methods, namely, surgery, radiotherapy, multichemotherapy, immunotherapy, and/or targeted therapy (1,2). However, current treatments often negatively impact the health, fertility, and even the lifespan of women.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility of pH-sensitive, chitosan-coated Fe3O4 nanoparticles in gynecological cells

Zhang

Wang²,

He³

et al. 2022

Front. Med.

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Nanoparticles that contact human cells without damaging basic human tissues are becoming more widely used in medicine. Efficient delivery to the intracellular target cell or compartment through the cell membrane must be achieved with minimal cytotoxicity to healthy cells. Fe3O4 nanoparticles have been widely used in biomedical research for their magnetic, non-toxic, and biocompatible properties. However, the effects of Fe3O4 nanoparticles coated with chitosan (CS) on gynecological cells are unclear. In this study, the Fe3O4 nanoparticles were coated with CS to enhance their cytocompatibility and dispersion in water. These CS-Fe3O4 nanoparticles were taken up by gynecological cells and did not affect cell viability in vitro. They have greater cytocompatibility in acidic environments than normal Fe3O4 nanoparticles and have the potential for drug delivery into gynecological cells.

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Section: Introductionmentioning

confidence: 99%

Cytocompatibility of pH-sensitive, chitosan-coated Fe3O4 nanoparticles in gynecological cells

Zhang

Wang²,

He³

et al. 2022

Front. Med.

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“…Even if the risk of spillage is lower during laparotomy, the potential benefits and the technical feasibility of laparoscopic approach suggest that could be a reasonable option in a great proportion of cases. Precautions to avoid rupture, including reconversion to laparotomy or in-bag protected specimen extraction, should be taken [46,47].…”

Section: Surgical Approachmentioning

confidence: 99%

“…In advanced stages, conservative treatment is more controversial [50]. Most of the recurrences are often observed in the preserved ovary [46]. Cystectomy has been an acceptable option for FSS, but the risk of recurrence could be the double compared with adnexectomy; for this reason, cystectomy should be reserved for those patients with recurrent disease or who previously underwent a contralateral adnexectomy [46,50].…”

Section: Safety Of Conservative Treatment In Ovarian Cancermentioning

confidence: 99%

Current limits of conservative treatment in ovarian cancer

Gracia¹,

Alonso-Espías²,

Zapardiel³

2023

Current Opinion in Oncology

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Purpose of review Fertility-sparing surgery in ovarian cancer is an increasing need in gynecology–oncology clinical practice because of the frequent childbearing delay in developed countries. As the evidence in literature is based on observational studies, this review focuses on summarizing the most recent and relevant evidence for the conservative management of young patients with ovarian cancer. Recent findings Staging surgery is mandatory in epithelial ovarian tumors. In sex cord-stromal tumors, fertility-sparing surgery is only recommended in FIGO stage IA. Due to its good prognosis, conservative treatment is possible in some cases of advanced disease of germ cell tumors and borderline tumors. Cystectomy is a reasonable option in serous borderline tumors but is not recommended in other tumor subtypes. Successful conception rates after fertility-sparing surgery ranges from 30 to 60%. Summary Fertility-sparing surgery is a well tolerated option in young women with early-stage ovarian cancer with acceptable reproductive outcomes.

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“…Para tumores de células germinativas ovarianas, a cirurgia de preservação da fertilidade é considerada padrão, porque esses tumores são extremamente sensíveis à quimioterapia (TAYLAN E e OKTAY K, 2019; NITECKI R, et al, 2020). Após a cirurgia conservadora e depois do sucesso de uma gestação, a ressecção secundária é recomendada, visto que existem grandes chances de recorrência (BENTIVEGNA E, et al, 2018).…”

Section: Revisão Bibliográficaunclassified

Preservação da fertilidade feminina em pacientes oncológicos

Odawara

Caetano

2022

Acervo Médico

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Objetivo: Revisar na literatura científica a respeito da preservação da fertilidade feminina em pacientes oncológicos, quais técnicas podem ser aplicadas para este fim, além de apresentar especificidades acerca dos cânceres ginecológicos. Revisão bibliográfica: Na oncologia, pacientes do sexo feminino submetidas à tratamento para câncer, muitas vezes experimentam a perda de sua capacidade reprodutiva e por isto são levadas a refletir acerca da possibilidade de uma maternidade futura, podendo com isso compreender as técnicas atuais disponíveis para manutenção da capacidade reprodutiva. As estratégias utilizadas incluem a criopreservação de oócitos, embriões e tecido ovariano, agonista de GnRH para proteção ovariana e cirurgias conservadoras no câncer ginecológico. O aconselhamento adequado está associado a menor arrependimento, conflito sobre suas decisões e melhor enfretamento do tratamento do câncer. Considerações finais: A preservação da fertilidade feminina é um aspecto de grande importância na oncologia, em que grande parte das pacientes perdem sua capacidade reprodutiva como consequência de efeitos gonadotóxicos dos tratamentos. Assim, as pacientes devem ser informadas sobre os riscos de infertilidade e dos possíveis desfechos após preservação da fertilidade, a fim de garantir decisões conscientes sobre sua própria fertilidade e família.

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Gynaecologic cancer surgery and preservation of fertility

Cited by 11 publications

References 36 publications

Cytocompatibility of pH-sensitive, chitosan-coated Fe3O4 nanoparticles in gynecological cells

Cytocompatibility of pH-sensitive, chitosan-coated Fe3O4 nanoparticles in gynecological cells

Current limits of conservative treatment in ovarian cancer

Preservação da fertilidade feminina em pacientes oncológicos

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