Abstract:BackgroundThe leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the incidence of cardiovascular diseases. Since significant differences in platelet function have been reported between human and animal platelets, a study focusing on the effect of A. purpurea extracts against human platelet activation is necessary.MethodsThe compounds in an A. purpurea ethanolic… Show more
“…Both norpurpureine (101) and purpureine (102) were isolated from Annona purpurea leaves. 61 nelumbinis. 30 Compounds 93, 97, and 98 as well as asimilobine (109), isopiline (110), O-methylisopiline (111), glaucine (112), and norglaucine (113) were reported for the first time from Unonopsis floribunda 35,36 ( Figure 5).…”
Section: F I G U R E 4 the Chemical Structures Of Compounds 57−84mentioning
confidence: 99%
“…acutum, in 2014 and 2016, respectively. 40,65 Five oxoaporphines isomoschatoline (129), O-methylmoschatoline (130), liriodenine (131), subsessiline (132), and lysicamine (133) were identified from Guatteria blepharophylla also in 2016 61 and compounds 131, 133 were reported from U. duckei in 2014. 59 One new 4,7-dihydroxy-7-methylaporphine alkaloid (7-hydroxyguatteriopsiscine (134)) and three new 7,7dimethylaporphinoids [(R)-dihydroguatteriscine (135), guatterfriesidine (136), and iso-9-methoxyguatterfriesine (137)] were isolated from the stem bark of G. friesiana in 2018.…”
Section: -Substituted Aporphines and Oxoaporphinesmentioning
confidence: 99%
“…113 Norsanguinarine 316 and cAMP signaling, such as the PLC-PKC-Ca 2+ pathway and phosphodiesterases. 61 SHANG ET AL.…”
Section: Neuroprotective Effectsmentioning
confidence: 99%
“…Both norpurpureine ( 101 ) and purpureine ( 102 ) were isolated from Annona purpurea leaves 61 . In 2018, eight aporphine alkaloids [anonaine ( 97 ), N ‐nornuciferine ( 98 ), nornuciferidine ( 103 ), zenkerine ( 104 ), O ‐nornuciferine ( 105 ), nuciferine ( 106 ), roemerine ( 107 ), and oxidation‐nuciferine (5‐hydroxynuciferine) ( 108 )] were identified from P. nelumbinis 30 .…”
Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning
confidence: 99%
“…Two oxoisoaporphines sallisonine E ( 127 ) and dauriporphine ( 128 ) were isolated from the rhizomes of S. acutum , in 2014 and 2016, respectively 40,65 . Five oxoaporphines isomoschatoline ( 129 ), O ‐methylmoschatoline ( 130 ), liriodenine ( 131 ), subsessiline ( 132 ), and lysicamine ( 133 ) were identified from Guatteria blepharophylla also in 2016 61 and compounds 131, 133 were reported from U. duckei in 2014 59 …”
Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning
Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.
“…Both norpurpureine (101) and purpureine (102) were isolated from Annona purpurea leaves. 61 nelumbinis. 30 Compounds 93, 97, and 98 as well as asimilobine (109), isopiline (110), O-methylisopiline (111), glaucine (112), and norglaucine (113) were reported for the first time from Unonopsis floribunda 35,36 ( Figure 5).…”
Section: F I G U R E 4 the Chemical Structures Of Compounds 57−84mentioning
confidence: 99%
“…acutum, in 2014 and 2016, respectively. 40,65 Five oxoaporphines isomoschatoline (129), O-methylmoschatoline (130), liriodenine (131), subsessiline (132), and lysicamine (133) were identified from Guatteria blepharophylla also in 2016 61 and compounds 131, 133 were reported from U. duckei in 2014. 59 One new 4,7-dihydroxy-7-methylaporphine alkaloid (7-hydroxyguatteriopsiscine (134)) and three new 7,7dimethylaporphinoids [(R)-dihydroguatteriscine (135), guatterfriesidine (136), and iso-9-methoxyguatterfriesine (137)] were isolated from the stem bark of G. friesiana in 2018.…”
Section: -Substituted Aporphines and Oxoaporphinesmentioning
confidence: 99%
“…113 Norsanguinarine 316 and cAMP signaling, such as the PLC-PKC-Ca 2+ pathway and phosphodiesterases. 61 SHANG ET AL.…”
Section: Neuroprotective Effectsmentioning
confidence: 99%
“…Both norpurpureine ( 101 ) and purpureine ( 102 ) were isolated from Annona purpurea leaves 61 . In 2018, eight aporphine alkaloids [anonaine ( 97 ), N ‐nornuciferine ( 98 ), nornuciferidine ( 103 ), zenkerine ( 104 ), O ‐nornuciferine ( 105 ), nuciferine ( 106 ), roemerine ( 107 ), and oxidation‐nuciferine (5‐hydroxynuciferine) ( 108 )] were identified from P. nelumbinis 30 .…”
Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning
confidence: 99%
“…Two oxoisoaporphines sallisonine E ( 127 ) and dauriporphine ( 128 ) were isolated from the rhizomes of S. acutum , in 2014 and 2016, respectively 40,65 . Five oxoaporphines isomoschatoline ( 129 ), O ‐methylmoschatoline ( 130 ), liriodenine ( 131 ), subsessiline ( 132 ), and lysicamine ( 133 ) were identified from Guatteria blepharophylla also in 2016 61 and compounds 131, 133 were reported from U. duckei in 2014 59 …”
Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning
Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.
The binding of four alkaloids with human serum albumin (HSA) was investigated by isothermal titration calorimetry (ITC), spectroscopy and molecular docking techniques. The findings demonstrated that theophylline or caffeine can bind to HAS, respectively. The number of binding sites and binding constants are obtained. The binding mode is a static quenching process. The effects of steric hindrance, temperature, salt concentration and buffer solution on the binding indicated that theophylline and HSA have higher binding affinity than caffeine. The fluorescence and ITC results showed that the interaction between HSA and theophylline or caffeine is an entropy‐driven spontaneous exothermic process. The hydrophobic force was the primary driving factor. The experimental results were consistent with the molecular docking data. Based on the molecular structures of the four alkaloids, steric hindrance might be a major factor in the binding between HSA and these four alkaloids. This study elucidates the mechanism of interactions between four alkaloids and HSA.
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