2018
DOI: 10.1038/s41409-018-0179-4
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A case-series of Toxoplasmosis in hematopoietic stem cell transplantation: still a concern for endemic countries

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Cited by 13 publications
(12 citation statements)
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“…In previous series, most toxoplasmosis cases occurred during the second or third months after allogeneic HCT, with a risk persisting across the first year of transplant and sometimes even later [10,11]. Cases occurring during the first 4 weeks of transplant have been rarely reported but seem to have a high mortality rate [1,5,7]. Our series clearly identifies toxoplasmosis as an early complication of allogeneic HCT.…”
Section: Discussionsupporting
confidence: 55%
See 1 more Smart Citation
“…In previous series, most toxoplasmosis cases occurred during the second or third months after allogeneic HCT, with a risk persisting across the first year of transplant and sometimes even later [10,11]. Cases occurring during the first 4 weeks of transplant have been rarely reported but seem to have a high mortality rate [1,5,7]. Our series clearly identifies toxoplasmosis as an early complication of allogeneic HCT.…”
Section: Discussionsupporting
confidence: 55%
“…Most cases of Toxoplasma are observed between 2 and 6 months after transplant, and even in the larger studies, early cases occurring before day 30 are very rare [1,5,7]. Because of recent, severe, and early cases of toxoplasmosis in our department, we reviewed all our Toxoplasma cases over the past 11 years, focusing on cases observed before day 30 after HCT.…”
Section: Introductionmentioning
confidence: 99%
“…The risks associated with transplantation are inadequately documented and probably underestimated (23)(24)(25)(26). Toxoplasmosis can occur in recipients both of solid organs and of hematopoietic stem cell transplants and may be due to reactivation of a pre-existing latent infection, to a newly acquired food-borne infection, or to tissue cysts contained in a transplant (24). Recent data show a significantly lower 6-month survival rate for T. gondii-seropositive recipients, especially after allogeneic stem cell transplantation (38% vs. 84%; p <0.001) and liver transplantation (50% vs. 75%; p <0.001) (23).…”
Section: Immunosuppression Infection and Reactivation In Transplant Recipientsmentioning
confidence: 99%
“…Toxoplasmosis after HSCT mainly manifests as disseminated toxoplasmosis, toxoplasmosis encephalopathy, toxoplasmosis ophthalmopathy and isolated fever 20 . According to our summary of patient data, central nervous system involvement is the most common presentation, accounting for 83.3% (15/18) of the cases.…”
Section: Discussionmentioning
confidence: 95%