2018
DOI: 10.3748/wjg.v24.i14.1531
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Punctual mutations in23S rRNAgene of clarithromycin-resistantHelicobacter pyloriin Colombian populations

Abstract: AIMTo characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori (H. pylori) and determine their association with therapeutic failure.METHODSPCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia, and 5 from a high-risk population: Tuquerres-Colombia) and 40 from a susceptible population (28 from Tumaco and 12 from Túquerres) were sequenced using capillary electroph… Show more

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Cited by 27 publications
(18 citation statements)
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References 23 publications
(38 reference statements)
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“…Therefore, alternative medication regimens (e.g., quadruple therapy or modified triple regimens) should be considered for effective eradication therapy in this area. Clarithromycin resistance is associated with point mutations of the V domain of 23S rRNA in the 50S subunit that decreases the affinity of drug binding to the ribosome [4,6]. In our study, A2143G was the most common type of mutation in strains.…”
Section: Discussionmentioning
confidence: 56%
See 1 more Smart Citation
“…Therefore, alternative medication regimens (e.g., quadruple therapy or modified triple regimens) should be considered for effective eradication therapy in this area. Clarithromycin resistance is associated with point mutations of the V domain of 23S rRNA in the 50S subunit that decreases the affinity of drug binding to the ribosome [4,6]. In our study, A2143G was the most common type of mutation in strains.…”
Section: Discussionmentioning
confidence: 56%
“…In the case of untreated and prolonged infection, H. pylori can cause peptic ulcer disease (PUD) and chronic gastritis (CG). Furthermore, neoplastic processes such as mucosa-associated lymphoid tissue (MALT) and gastric cancer (GC) are associated with this microorganism [3,4]. The International Agency for Research on Cancer classified H. pylori as class I carcinogen in 1994 [5].…”
Section: Introductionmentioning
confidence: 99%
“…clarithromycin-resistant 23srRNA (Matta et al, 2018), rpmJ, hp0605, hp0971 (Iwamoto et al, 2014), acrB (Binh et al, 2014) Campylobacter spp.…”
Section: Helicobacter Pylorimentioning
confidence: 99%
“…At present, the mechanism of antibiotic resistance of Hp is not completely understood [10][11] . It is widely accepted that the resistance to these antimicrobials is related to mutations in Hp gene: clarithromycin-resistant strains present three-point mutations in the region of domain V of 23S ribosomal RNA (rRNA): A2142G, A2142C and A2143G [12][13] . In addition to the mutations, the e ux pump cluster is also involved in the development of resistance to clarithromycin [14][15] .…”
Section: Introductionmentioning
confidence: 99%