Antimicrobial resistance is one of the leading challenges in the human healthcare segment. Advances in antimicrobial resistance has trigger to explore naturally occurring alternatives to stabilize its seriousness. Antimicrobial peptides are small positively charged oligopeptides and are equally potent as that of commercially available antibiotics against broad class of organisms such as Gram-positive bacteria, Gram-negative bacteria, viruses and fungal strains. Along with this, they possess anticancerous activity, activates immune response and regulates inflammation. Peptides have discrete mode of action and fall into various categories due to their amino acid composition. Although Antimicrobial peptides specifically target bacterial cytoplasmic membrane but they can also target their nucleus and protein synthesis as well. Due to increasing demand of novel treatment therapy against brooding antimicrobial resistance, naturally synthesized peptides are a beneficial concept of development. Antimicrobial peptides are pervasive and can be easily modified using de-novo synthesis technology. Antimicrobial peptides can be isolated from natural resources such as humans, plants, bacteria and fungi. This review gives a brief over antimicrobial peptides and its diastereomeric composition. Further current trends and future scope associated with antimicrobial peptides and role of D-amino acids is also discussed with specific emphasis on the design and development of new drugs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.