Both alcoholic and non-alcoholic steatohepatitis association with cardiovascular risk and liver fibrosis

Sánchez-Jiménez, Beatriz A; Brizuela-Alcántara, Diana C.; Ramos-Ostos, Martha Helena; Alva-López, Luis Felipe; Uribe, Misael; Chávez-Tapia, Norberto C.

doi:10.1016/j.alcohol.2017.11.004

Cited by 20 publications

(19 citation statements)

References 33 publications

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“…Studies have shown that engaging in binge drinking behavior can lead to longterm alcohol use disorders and alcohol dependence (38)(39)(40). Heavy alcohol consumption is known to be associated with liver diseases, cancers, and cardiovascular disease risk (41,42), which increases mortality rates and brings upon significant social and economic loss to society. Given the potential for future shelter-inplace mandates as the pandemic continues, future research should aim to develop strategies to prevent and intervene on binge drinking behaviors while people are in isolation.…”

Section: Discussionmentioning

confidence: 99%

Longer time spent at home during COVID-19 pandemic is associated with binge drinking among US adults

Weerakoon

Jetelina

Knell

2020

The American Journal of Drug and Alcohol Abuse

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Section: Discussionmentioning

confidence: 99%

Longer time spent at home during COVID-19 pandemic is associated with binge drinking among US adults

Weerakoon

Jetelina

Knell

2020

The American Journal of Drug and Alcohol Abuse

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“…Indeed, the additive effects of alcohol and obesity on cardiovascular risk have been demonstrated previously; patients with hepatic steatosis due to obesity and alcohol use have higher cardiovascular risk than those with steatosis due to obesity alone. 28 LT recipients with BASH were also more likely to have other risk factors for mortality than patients with ALD, including pre-LT malignancy, longer wait time, and a higher proportion of male recipients.…”

Section: Outcomes Of Lt For Bashmentioning

confidence: 99%

Both Alcoholic and Nonalcoholic Steatohepatitis Is an Emerging Indication for Liver Transplantation in the United States

Fritze

Singh

Lawitz

et al. 2020

Digestive Disease Interventions

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Abstract Background Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) are now the most common indications for liver transplantation (LT) in the United States. A subset of patients have both alcoholic and nonalcoholic steatohepatitis (BASH). This study characterizes patients with BASH requiring LT and assesses changes in the prevalence of BASH as an indication for LT. Methods The United Network for Organ Sharing database was analyzed for all patients ≥ 18 years of age who received their first deceased donor LT from 2002 to 2016 for ALD, NASH, or BASH. Baseline demographics, clinical parameters, and LT outcomes were compared between groups. Results Since 2002, 85,448 patients underwent LT:15,327 had ALD, 9,971 had NASH, and 2,779 had BASH. The prevalence of BASH as an indication for LT increased from 0.5% in 2002 to 5% in 2016. Compared with patients with NASH, those with BASH were significantly more likely to be male (85.6 vs. 57%), younger (mean 56.4 vs. 58.6 years), and Hispanic (22.2 vs. 13.6%) (p < 0.001 for all). While indication for transplant was not significantly associated with transplant outcomes on multivariable analysis, patient and graft survival curves do differ significantly by indication for transplant, with worse outcomes for patients with BASH (patient survival at 5 years: NASH 78.1%, ALD 77.2%, BASH 73.5%, p = 0.013; graft survival at 5 years: NASH 75.3%, ALD 74.0%, BASH 70.8%, p = 0.046). Conclusions BASH is a rising indication for LT, especially for Hispanic males, due to the increasing prevalence of ALD and NASH in the United States.

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“…Alcohol acts synergistically with obesity and diabetes in the progression to cirrhosis and hepatocellular carcinoma [93], patients with both NAFLD and ALD have more advanced fibrosis compared to those with NAFLD alone [25]. Indeed, steatohepatitis from both NAFLD and ALD is associated with higher risk of cardiovascular disease and outcomes than either NASH or ASH alone [129,130]. Hepatic fibrosis has been shown to predict patient mortality [131], so clinicians have relied on elastographic techniques to evaluate severity and make appropriate decisions.…”

Section: Steatohepatitis (Nash/ash)mentioning

confidence: 99%

Multiparametric MR mapping in clinical decision-making for diffuse liver disease

Thomaides-Brears¹,

Lepe

Banerjee³

et al. 2020

Abdom Radiol

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Accurate diagnosis, monitoring and treatment decisions in patients with chronic liver disease currently rely on biopsy as the diagnostic gold standard, and this has constrained early detection and management of diseases that are both varied and can be concurrent. Recent developments in multiparametric magnetic resonance imaging (mpMRI) suggest real potential to bridge the diagnostic gap between non-specific blood-based biomarkers and invasive and variable histological diagnosis. This has implications for the clinical care and treatment pathway in a number of chronic liver diseases, such as haemochromatosis, steatohepatitis and autoimmune or viral hepatitis. Here we review the relevant MRI techniques in clinical use and their limitations and describe recent potential applications in various liver diseases. We exemplify case studies that highlight how these techniques can improve clinical practice. These techniques could allow clinicians to increase their arsenals available to utilise on patients and direct appropriate treatments.

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Both alcoholic and non-alcoholic steatohepatitis association with cardiovascular risk and liver fibrosis

Cited by 20 publications

References 33 publications

Longer time spent at home during COVID-19 pandemic is associated with binge drinking among US adults

Longer time spent at home during COVID-19 pandemic is associated with binge drinking among US adults

Both Alcoholic and Nonalcoholic Steatohepatitis Is an Emerging Indication for Liver Transplantation in the United States

Multiparametric MR mapping in clinical decision-making for diffuse liver disease

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