Coxiella burnetii: A Hidden Pathogen in Interstitial Lung Disease?

Melenotte, Cléa; Izaaryene, Jean; Gomez, Carine; Delord, M; Prudent, Elsa; Lépidi, Hubert; Mediannikov, Oleg; Lacoste, M.; Djossou, Félix; Mania, Alexandre; Bernard, N.; Huchot, É.; Mège, Jean‐Louis; Raoult, Didier

doi:10.1093/cid/ciy278

Cited by 11 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All patients had severe and advanced fibrotic lung lesions. 19 A pseudotumor of the lung was detected in 3 patients. One had persistent endocarditis, 1 had persistent lymphadenitis, and 1 had acute Q fever.…”

Section: Resultsmentioning

confidence: 99%

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

et al. 2018

Self Cite

View full text Add to dashboard Cite

Key Points Question What are the characteristics and clinical presentations of Coxiella burnetii infection using 21st-century–clarified definitions? Finding In a cohort study of 2434 patients with Q fever, the following new critical Q fever foci were identified: acute endocarditis, lymphadenitis, and bone marrow involvement in hemophagocytic syndrome. Lymphadenitis is a risk factor for lymphoma, and the elevation of IgG anticardiolipin antibody titers in acute Q fever is associated with complications. Meaning Screening for anticardiolipin antibodies may help prevent acute Q fever complications; the use of transthoracic echocardiography in acute Q fever and positron emission tomographic scanning in suspected persistent focalized infection is justified to improve the care of patients with Q fever.

show abstract

Section: Resultsmentioning

confidence: 99%

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, we speculate that in our patient if the diagnosis of Q fever had been delayed further, chronic inflammation in the lungs could have triggered progression to “idiopathic interstitial lung disease.” In fact, before the Q fever serology result was available, there was already a tentative plan to treat the patient with steroids for possible interstitial pneumonitis. Interestingly, C burnetii has been incriminated as an etiologic agent of interstitial lung disease, and in a recent study, C burnetii was demonstrated in the lung biopsy specimen of a patient with interstitial lung disease by immunohistochemical staining of C burnetii antigen and fluorescence in situ hybridization targeting specific C burnetii ribosomal RNA and DNA . However, C burnetii is generally not sought in the workup of interstitial lung disease thus undermining its possible role in the pathogenesis of chronic lung disease.…”

Section: Discussionmentioning

confidence: 89%

“…Of note, while Q fever is often associated with fever, lack of fever as in this case is well documented in both acute and chronic Q fever . Finally, the lungs are uncommon foci of persistent chronic infection . In the published literature, the heart, blood vessels, bones, and occasionally lymph nodes are noted as sites of persistent chronic Q fever.…”

Section: Discussionmentioning

confidence: 99%

“…et alC burnetii ribosomal RNA and DNA 14. However, C burnetii is generally not sought in the workup of interstitial lung disease thus undermining its possible role in the pathogenesis of chronic lung disease.Moreover, the diagnostic tests in SOT recipients presenting with an illness focus on opportunistic infections, and Q fever is often not in the differential diagnosis of these patients.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Unusual presentation of Q fever in a kidney‐pancreas transplant recipient

Poch

İnce

Thomas

et al. 2018

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

“…The most commonly observed manifestation of chronic Q fever is endocarditis following hematogenous spread from the lungs (Aistleitner et al, 2018 ). Chronic Q fever can also present as chronic fatigue syndrome (Roest et al, 2013 ), fibrosis (Melenotte et al, 2018a ), osteomyelitis (Merhej et al, 2012 ), and hepatitis (Gomes et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes

Psaroulaki

Mathioudaki

Vranakis

et al. 2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Coxiella burnetii is the agent that causes acute and chronic Q fever infections in humans. Although the isolates studied so far have shown that the two forms of the disease differ in virulence potential thus, implying a variance in their proteomic profile, the methods used do not deliver enough discriminatory capability and often, human infections may be mis-diagnosed. The current study adds further knowledge to the results that we have already published on the Coxiella outer membrane protein 1 (Com1). Herein we identified the proteins GroEL, Ybgf, OmpH, and UPF0422 as candidates for serodiagnostics of Q fever; following cloning, expression and purification they were further used as antigens in ELISA for the screening of patients' sera associated with chronic Q fever endocarditis, sera negative for phase I IgG, sera with at least one sample positive for phase I IgG and sera from patients who suffered from various rheumatic diseases. Blood donors were used as the controls. Sensitivity, specificity, positive predictive value, negative predictive value, and Cohen's kappa coefficient (κ) were calculated and we also performed binary logistic regression analysis to identify combinations of proteins with increased diagnostic yield. We found that proteins GroEL and Ybgf, together with Com1, play the most significant role in the correct diagnosis of chronic Q fever. Of these three proteins, it was shown that Com1 and GroEL present the highest sensitivity and specificity altogether. The results add to the existing knowledge that an antigen-based serodiagnostic test that will be able to correctly diagnose chronic Q fever may not be far from reality.

show abstract

Coxiella burnetii: A Hidden Pathogen in Interstitial Lung Disease?

Abstract: We report 7 patients with interstitial lung disease seen at computed tomographic scan review. Coxiella burnetii infection was diagnosed in situ in 1 lung biopsy specimen. Q fever may be a cofactor of interstitial lung disease, especially in endemic areas.

Cited by 11 publications

References 11 publications

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

Clinical Features and Complications ofCoxiella burnetiiInfections From the French National Reference Center for Q Fever

Unusual presentation of Q fever in a kidney‐pancreas transplant recipient

In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes

Contact Info

Product

Resources

About