Seroprevalence and risk factors of hepatitis E virus infection in cancer patients in eastern China

Bai, Meng-Jie; Zhou, Na; Wang, Dong; Li, Guangxing; Cong, Wei; Zhu, Xing‐Quan

doi:10.1016/j.ijid.2018.04.003

Cited by 23 publications

(31 citation statements)

References 38 publications

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“…These authors hypothesized that past HEV infection may increase the severity of HBV or HCV infection and accelerate progression to HCC in such a setting. In China, Bai et al found a three-fold greater HEV seroprevalence among 103 patients with liver cancer than in 950 control volunteers (31% vs. 13%) (Bai et al, 2018). In that study, HBV and HCV co-infections were not documented in the HCC patients, and HEV seroprevalence was also significantly increased in association with other cancers.…”

mentioning

confidence: 74%

Hepatitis E virus as an agent of hepatocellular carcinoma

Colson¹,

Borentain

Gerolami³

2019

International Journal of Infectious Diseases

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mentioning

confidence: 74%

Hepatitis E virus as an agent of hepatocellular carcinoma

Colson¹,

Borentain

Gerolami³

2019

International Journal of Infectious Diseases

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“…The diseased patients are normally immuno-suppressed or immunocompromised, and received blood transfusions, immunosuppressive medications or cancer chemotherapy which prompts their higher vulnerability to HEV. In rural cancer patients the seroprevalence of HEV was 27.8% marginally higher and pigs act as main reservoir of HEV in these areas as compared to urban cancer patients (24.2%) 91 . Prevalence of HEV was also examined in the Nepalese HIV Fig.…”

Section: Cases Related To High Risk Patientsmentioning

confidence: 84%

Hepatitis E: Current Status in India and Other Asian Countries

Kumar¹,

Kamar²,

Kumar³

2019

J Pure Appl Microbiol

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Six types of hepatitis infections are accounted for the inflammation of liver in human throughout the world and assigned the letter A, B, C, D, E and G. Out of these, Hepatitis E, caused by Hepatitis E virus (HEV), currently categorized as a member of the genus Hepevirus in the family Hepeviridae. Hepatitis E is considered highly significant, on account of its predominance in both developed and developing nations, due to poor sanitation and cleanliness condition related to drinking water. This review focuses on general epidemiological study update of hepatitis E virus in India and rest of Asia for the selected period and also throws light on some diagnostic approaches available for the same. An extensive literature search was performed with published work and search in PubMed using term "HEV" combined with "country name" restricting the search publication between year 2008 to 2018 for India and 2013 to 2018 for the rest of Asia. The data was analyzed in detail to meet the requirements of the objectives. Study showed that in India the major causes of Hepatitis E was water contaminated with fecal matter. Reports from East and Southeast Asia signified the role of animal reservoir especially the pigs for HEV. Whereas in Indian neighboring countries like Nepal, Pakistan and Western Asia the major cases of Hepatitis E were associated with blood transfusion and pregnancy related cases. Majority of the diagnostic approaches used in India at medical facilities are based on anti-HEV IgM detection. However, the molecular based approaches played very crucial role in HEV detection. It is observed that the incidence of HEV is gradually expanding and its objective range is not only just developing countries, but also showing an enhancement. In overall, there is need for improvements in detection of HEV disease and methodologies used for the development of HEV vaccines.

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“…Recent data produced both in Eastern Asia or sub-Saharan Africa, however, indicate that HEV infection might represent a risk factor of chronic liver disease progression leading ultimately to hepatocellular carcinoma (HCC) (Amanya et al, 2017[2]; Amougou Atsama et al, 2017[3]; Bai et al, 2018[6]; Diwe et al, 2013[9]).…”

Section: Discussionmentioning

confidence: 99%