Hepatitis E virus as an agent of hepatocellular carcinoma

Colson, Philippe; Borentain, Patrick; Gerolami, René

doi:10.1016/j.ijid.2018.12.015

Cited by 6 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our transplant cohort, LTRs showed the highest seroprevalence rate of 19.3%, and in the risk analysis for HEV IgG seropositivity exhibited the highest OR of 5.058 among tested groups. This supports the hypothesis that HEV in combination with other factors may promote chronic inflammation and even be a cofactor in hepatocellular carcinoma occurrence leading to liver transplant candidacy[ 30 ]. Chronicity of HEV infection is of emerging relevance in transplant recipients; however, there are still conflicting viewpoints on the overall anti-HEV seroprevalence and rate of chronic HEV infection in immunocompromised patients[ 31 ].…”

Section: Discussionsupporting

confidence: 86%

Insights into hepatitis E virus epidemiology in Croatia

Jeličić¹,

Ferenc²,

Mrzljak³

et al. 2022

World J Gastroenterol

View full text Add to dashboard Cite

BACKGROUND Hepatitis E virus (HEV) is an emerging virus of global health concern. The seroprevalence rates differ greatly according to geographic region and population group. AIM To analyze the seroprevalence of HEV in exposed (animal-related professions) and nonexposed populations, as well as solid organ and hematopoietic stem cell transplant patients. METHODS Forestry workers ( n = 93), hunters ( n = 74), and veterinarians ( n = 151) represented the exposed population. The general population ( n = 126) and pregnant women ( n = 118) constituted the control group. Transplant patients included liver transplant recipients (LTRs) ( n = 83), kidney transplant recipients (KTRs) ( n = 43), and hematopoietic stem cell transplant recipients (HSCRs) ( n = 39). HEV immunoglobulin G antibodies were detected using the enzyme-linked immunosorbent assay and confirmed by the immunoblot test. RESULTS The HEV seroprevalence significantly differed between groups: Veterinarians 15.2%, hunters 14.9%, forestry workers 6.5%, general population 7.1%, and pregnant women 1.7%. In transplant patients, the seropositivity was highest in LTRs (19.3%), while in KTRs and HSCRs, the seroprevalence was similar to the general population (6.9% and 5.1%, respectively). A significant increase in seropositivity with age was observed from 2.9% in individuals less than 30 years to 23.5% in those older than 60 years. Sociodemographic characteristics (sex, educational level, area of residence, and number of household members), eating habits (game meat, offal, and pork products consumption), and environmental and housing conditions (drinking water supply, type of water drainage/sewer, waste disposal, domestic animals) were not associated with HEV seropositivity. However, individuals who reported a pet ownership were more often seropositive compared to those who did not have pet animals (12.5% vs 7.0%). CONCLUSION The results of this study showed that individuals in professional contact with animals and LTRs are at higher risk for HEV infection. In addition, age is a significant risk factor for HEV seropositivity.

show abstract

Section: Discussionsupporting

confidence: 86%

Insights into hepatitis E virus epidemiology in Croatia

Jeličić¹,

Ferenc²,

Mrzljak³

et al. 2022

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…HEV can cause chronic infection, which means that it has the same potential to cause HCC as other hepatitis viruses (HBV and HCV) that cause chronic infection. Some mechanisms of chronic viral hepatitis leading to HCC are common, such as long-term chronic inflammatory infiltration and disruption of cellular pathways caused by the interaction between viral proteins and host factors [133,134]. It is particularly noteworthy that a case of HCC complicated with chronic hepatitis E was described in a report, suggesting that HEV is closely related to the development of HCC, if not the primary cause of HCC [30].…”

Section: Hepatitis E Virus and Hepatocellular Carcinomamentioning

confidence: 99%

“…Almost all cases that are virologically unresponsive or relapsed can be cured by an additional six-month course. All these may have contributed to the neglect of HEV infection and its role in HCC patients [134].…”

Section: Hepatitis E Virus and Hepatocellular Carcinomamentioning

confidence: 99%

Hepatitis Virus and Hepatocellular Carcinoma: Recent Advances

Shen¹,

Jiang²,

Li³

et al. 2023

Cancers

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) remains a global health challenge, causing 600,000 deaths each year. Infectious factors, including hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV), have long been considered the major risk factors for the development and progression of HCC. These pathogens induce hepatocyte transformation through a variety of mechanisms, including insertional mutations caused by viral gene integration, epigenetic changes, and the induction of long-term immune dysfunction. The discovery of these mechanisms, while advancing our understanding of the disease, also provides targets for new diagnostic and therapeutic approaches. In addition, the discovery and research of chronic HEV infection over the past decade indicate that this common hepatitis virus also seems to have the potential to induce HCC. In this review, we provide an overview of recent studies on the link between hepatitis virus and HCC, as well as new diagnostic and therapeutic approaches to HCC based on these findings. Finally, we also discuss the potential relationship between HEV and HCC. In conclusion, these associations will further optimize the diagnosis and treatment of infection-associated HCC and call for better management policies.

show abstract

“…MiR-214 exerts morphogenesis of the muscles, skeleton and nervous system, and at the same time plays a diverse role in the development of different cancers types; it stimulates the progression of gastric, ovarian and lung cancer, but suppresses liver and cervical cancers [ 63 ]. HEV is a hepatotropic virus with possible link for development of hepatocellular carcinoma after chronicity in immunocompromised patients or in presence of underlying liver disease [ 64 ]. Thus, looking for binding sites for miRNAs with an established role in liver pathogenesis is understandable.…”

Section: Host Mirna Affecting Hev Life Cyclementioning

confidence: 99%