Noninvasive measurement of glucose concentration on human fingertip by optical coherence tomography

Chen, Tseng Lin; Lo, Yu Lung; Liao, Chia Chi; Phan, Quoc Hung

doi:10.1117/1.jbo.23.4.047001

Cited by 35 publications

(22 citation statements)

References 30 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The optical method measures the intrinsic molecular properties of glucose in body samples other than blood, such as the absorption of near-infrared or mid-infrared radiation [12,13], polarimetry [14], Raman spectroscopy [15], photo-acoustic absorption [16], light scattering [17], optical coherence tomography [18], confocal reflectometry [19], fluorescence spectroscopy [20], and contact lenses [21,22]. The main concerns associated with glucose-measuring optical technologies include the difficulties achieving sufficient accuracy at an affordable cost for home-care users without the use of blood to perform the measurement.…”

Section: Discussionmentioning

confidence: 99%

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit

et al. 2021

View full text Add to dashboard Cite

The noninvasive measurement of serum glucose levels has been investigated for the monitoring of blood sugar control in diabetes. In our study, we aimed to develop a novel noncontact glucometer (NCGM) utilizing an optical approach to measure the intraocular aqueous humor glucose levels in the anterior chamber of rabbit eyes. The NCGM consists of a hybrid optical system that simultaneously measures near-infrared absorption and the polarized rotatory distribution of glucose molecules in the aqueous humor. In vitro optical measurements demonstrated that NCGM measurements had high precision and repeatability for different glucose levels, including 50 mg/dL (14.36%), 100 mg/dL (−4.05%), 200 mg/dL (−5.99%), 300 mg/dL (4.86%), 400 mg/dL (−2.84%), 500 mg/dL (−0.11%), and 600 mg/dL (4.48%). In the rabbit experiments, we found a high correlation between aqueous glucose levels and serum glucose levels, with a mean difference of 8 mg/dL. According to the testing results, the in vivo NCGM measurement of aqueous humor glucose levels also displayed a high correlation with serum glucose levels, with a mean difference of 29.2 mg/dL. In conclusion, aqueous humor glucose levels were accurately measured using the NCGM, and the results correlated with serum glucose levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A second approach is to increase sensitivity to glucose by implanting a glucose recognition unit under the skin [143,144]. A third solution to improve the selective detection of glucose is a combined OCT technique with the Mueller matrix polarimetry technique [145] and a combined OCT technique with dual-wavelength absorption based technique [117,146,147]. Measurements made using various combinations of OCT methods have resulted in detection limits between 2.4 and 69.6 mg/dL for glucose within the anterior chamber of the eye model [117,147].…”

Section: Tissue Heterogeneity and Scattering Of Light By Tissuementioning

confidence: 99%

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Shokrekhodaei

Quinones

2020

Sensors

145

109

View full text Add to dashboard Cite

Annual deaths in the U.S. attributed to diabetes are expected to increase from 280,210 in 2015 to 385,840 in 2030. The increase in the number of people affected by diabetes has made it one of the major public health challenges around the world. Better management of diabetes has the potential to decrease yearly medical costs and deaths associated with the disease. Non-invasive methods are in high demand to take the place of the traditional finger prick method as they can facilitate continuous glucose monitoring. Research groups have been trying for decades to develop functional commercial non-invasive glucose measurement devices. The challenges associated with non-invasive glucose monitoring are the many factors that contribute to inaccurate readings. We identify and address the experimental and physiological challenges and provide recommendations to pave the way for a systematic pathway to a solution. We have reviewed and categorized non-invasive glucose measurement methods based on: (1) the intrinsic properties of glucose, (2) blood/tissue properties and (3) breath acetone analysis. This approach highlights potential critical commonalities among the challenges that act as barriers to future progress. The focus here is on the pertinent physiological aspects, remaining challenges, recent advancements and the sensors that have reached acceptable clinical accuracy.

show abstract

“…Optical sensors are being utilized in a wide variety of applications [8,[93][94][95][96]. Optical measurements can be taken from equipment such as the spectrophotometer, which are intended for use in a large-scale setup such as a clinic or a laboratory.…”

Section: Optical Sensorsmentioning

confidence: 99%

Wearable Skin Sensors and Their Challenges: A Review of Transdermal, Optical, and Mechanical Sensors

2020

View full text Add to dashboard Cite

Wearable technology and mobile healthcare systems are both increasingly popular solutions to traditional healthcare due to their ease of implementation and cost-effectiveness for remote health monitoring. Recent advances in research, especially the miniaturization of sensors, have significantly contributed to commercializing the wearable technology. Most of the traditional commercially available sensors are either mechanical or optical, but nowadays transdermal microneedles are also being used for micro-sensing such as continuous glucose monitoring. However, there remain certain challenges that need to be addressed before the possibility of large-scale deployment. The biggest challenge faced by all these wearable sensors is our skin, which has an inherent property to resist and protect the body from the outside world. On the other hand, biosensing is not possible without overcoming this resistance. Consequently, understanding the skin structure and its response to different types of sensing is necessary to remove the scientific barriers that are hindering our ability to design more efficient and robust skin sensors. In this article, we review research reports related to three different biosensing modalities that are commonly used along with the challenges faced in their implementation for detection. We believe this review will be of significant use to researchers looking to solve existing problems within the ongoing research in wearable sensors.

show abstract

Noninvasive measurement of glucose concentration on human fingertip by optical coherence tomography

Cited by 35 publications

References 30 publications

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Wearable Skin Sensors and Their Challenges: A Review of Transdermal, Optical, and Mechanical Sensors

Contact Info

Product

Resources

About