2018
DOI: 10.1002/mds.27387
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Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease

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Cited by 6 publications
(9 citation statements)
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“…Senescent astrocytes are also more prominent in brain tissues from patients with other neurodegenerative diseases, such as Parkinson's disease (PD) (Chinta et al, 2018;Scott and Williams-Gray, 2018) and amyotrophic lateral sclerosis (ALS) (Turnquist et al, 2016;Vazquez-Villasenor et al, 2019). PD is the second most common age-related neurodegenerative disease, characterized by loss of neurons in the substantia nigra pars compacta (SNpc), accumulation of α-synuclein, and presence of intraneuronal proteinaceous cytoplasmic inclusions (Lewy bodies) (Dauer and Przedborski, 2003).…”
Section: Astrocyte Senescence and Other Neurodegenerative Diseasesmentioning
confidence: 99%
“…Senescent astrocytes are also more prominent in brain tissues from patients with other neurodegenerative diseases, such as Parkinson's disease (PD) (Chinta et al, 2018;Scott and Williams-Gray, 2018) and amyotrophic lateral sclerosis (ALS) (Turnquist et al, 2016;Vazquez-Villasenor et al, 2019). PD is the second most common age-related neurodegenerative disease, characterized by loss of neurons in the substantia nigra pars compacta (SNpc), accumulation of α-synuclein, and presence of intraneuronal proteinaceous cytoplasmic inclusions (Lewy bodies) (Dauer and Przedborski, 2003).…”
Section: Astrocyte Senescence and Other Neurodegenerative Diseasesmentioning
confidence: 99%
“…While reactive astrocytes have emerged as an important contributor to pathogenesis [12,150], few studies have examined therapeutic approaches to attenuating astrocytic oxidative/nitrosative stress in PD. Salidroside, extracted from Rhodiola rosea , decreased ROS production and increased viability in a neuron–astrocyte co-culture model [151].…”
Section: Pharmacological Attenuation Of Astrocytic Oxidative/nitromentioning
confidence: 99%
“…In particular, midbrain astrocytes are uniquely positioned to drive neuroprotective and regenerative programs in PD. Therefore, targeting not only diseased neurons, but specifically manipulating astroglial cells may provide a new approach for drug development for the treatment of neurological diseases, as PD [ [293] , [294] , [295] , [296] , [297] , [298] , [299] ] ( Fig. 8 ).…”
Section: The Therapeutic Impact: a Glial Avenue For Nigrostriatal Resmentioning
confidence: 99%
“…The possibility of modifying the pathologic brain environment by utilizing the neurotrophic properties of astrocytes is being actively pursued using different approaches, including derivation of astrocyte differentiated from NSCs or hiPSC sources, or conversion of fibroblasts directly into astrocytes, astrocyte co-transplantaion and astrocyte reprogramming [ [293] , [294] , [295] , [296] , [297] , [298] , [299] ]. Genetic manipulation of astrocytes to deliver at the location of active neuropathology potential neuroprotective molecules was studied by different authors Gene therapy approaches for PD can deliver neurotrophic factors such as GDNF or neurturin via neuronal transgene expression.…”
Section: The Therapeutic Impact: a Glial Avenue For Nigrostriatal Resmentioning
confidence: 99%