Imaging Macrophage-associated Inflammation

Foss, Catherine A.; Sanchez-Bautista, Julián; Jain, Sanjay

doi:10.1053/j.semnuclmed.2017.12.002

Cited by 16 publications

(6 citation statements)

References 42 publications

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“…Several radiotracers have been developed to target macrophages in vivo in the preclinical and clinical setting. In the past years, macrophage-targeted radiotracers have been mainly used to investigate inflammation-associated diseases including neuroinflammatory, rheumatoid and infectious diseases 19, 20. More recently, a growing number of studies suggest the value of macrophage-specific radiotracers in the field of cancer diagnosis and therapy, which will be discussed in this section.…”

Section: Macrophage Targeting Radiopharmaceuticalsmentioning

confidence: 99%

The yin and yang of imaging tumor associated macrophages with PET and MRI

Mukherjee¹,

Sonanini²,

Maurer³

et al. 2019

Theranostics

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Tumor associated macrophages (TAM) are key players in the cancer microenvironment. Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM dynamics in tumors non-invasively, based on specific uptake and quantification of MRI-detectable nanoparticles or PET-detectable radiotracers. Particular molecular signatures can be leveraged to target anti-inflammatory TAM, which support tumor growth, and pro-inflammatory TAM, which suppress tumor growth. In addition, TAM-directed imaging probes can be designed to include immune modulating properties, thereby leading to combined diagnostic and therapeutic (theranostic) effects. In this review, we will discuss the complementary role of TAM-directed radiotracers and iron oxide nanoparticles for monitoring cancer immunotherapies with PET and MRI technologies. In addition, we will outline how TAM-directed imaging and therapy is interdependent and can be connected towards improved clinical outcomes

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Section: Macrophage Targeting Radiopharmaceuticalsmentioning

confidence: 99%

The yin and yang of imaging tumor associated macrophages with PET and MRI

Mukherjee¹,

Sonanini²,

Maurer³

et al. 2019

Theranostics

View full text Add to dashboard Cite

show abstract

“…Macrophages are part of the first line of defense against injury, mediating the innate non-specific immune response via inflammation, and playing an important role not only in host defense but in tissue homeostasis, repair, and pathology development including IBD [21,22]. RAW 264.7 mouse derived macrophages have been widely used as in vitro model to study modulatory effects of several compounds using LPS for activation [23,24,25].…”

Section: Resultsmentioning

confidence: 99%

BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo

et al. 2019

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BG-4 isolated from bitter gourd has been reported for anti-cancer properties. The objective was to evaluate the anti-inflammatory properties of BG-4 in vitro and in vivo. Comparative study of the anti-inflammatory properties of BG-4 in vitro and in vivo was conducted on lipopolysaccharide (LPS)-activated mouse macrophages, and on dextran sodium sulfate (DSS)-induced colitis in mice. BG-4 reduced the production of pro-inflammatory markers in LPS-activated macrophages. On the other hand, intraperitoneal administration of BG-4 in DSS-induced colitis led to colon shortening, elevated neutrophils infiltration and myeloperoxidase activity, presence of blood in the stool, and loss of body weight, with differential systemic and local effects on pro-inflammatory cytokines in vivo. The results demonstrated that BG-4 differentially affected inflammation in vitro and in vivo.

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“…One of the pathogenesis of IBD is the inflammation caused by the altered immune system (Wallace et al, 2014, Rogler, 2017, thus, regulating this process has profound significance for IBD therapy. As immune cells, macrophages play an important role in many aspects of inflammation (Hamidzadeh et al, 2017, Foss et al, 2018. It is proved that the increase of M1 macrophages in the colon is related to the severity and progress of IBD (Leonardi et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease

et al. 2020

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Herein, we unfolded miR-98-5p mechanism in inflammatory bowel disease (IBD). IBD mouse model was established. The severity of colitis was assessed daily using the disease activity index (DAI). Murine peritoneal macrophages were stimulated by lipopolysaccharide (LPS). MiR-98-5p, tribbles homolog 1 (Trib1), M1 and M2 macrophage marker genes mRNA expression was analyzed. The relationship between miR-98-5p and Trib1 was explored using a luciferase reporter assay. The strategy of loss-of-function was used to explore the mechanism of miR-98-5p in macrophage polarization, inflammation and IBD. The results revealed that IBD mice had higher DAI index and miR-98-5p expression when compared to the Sham group. MiR-98-5p and Trib1 displayed a targeted regulation relationship. Knockdown of miR-98-5p transformed LPS-induced M1 macrophage polarization into M2 macrophage polarization and inhibited inflammation via up-regulating Trib1. However, shTrib1 reversed the effects. In vivo experiment, silencing of miR-98-5p, diminished the DAI and promoted M2 macrophage polarization. In conclusion, knockdown of miR-98-5p changed macrophage polarization to the M2 phenotype by increasing Trib1 expression, thereby alleviating IBD symptoms.

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Imaging Macrophage-associated Inflammation

Cited by 16 publications

References 42 publications

The yin and yang of imaging tumor associated macrophages with PET and MRI

The yin and yang of imaging tumor associated macrophages with PET and MRI

BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo

MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease

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