H1N1 seasonal influenza virus evolutionary rate changed over time

Suptawiwat, Ornpreya; Kongchanagul, Alita; Boonarkart, Chompunuch; Auewarakul, Prasert

doi:10.1016/j.virusres.2018.03.020

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Influenza viruses induce annual epidemics and casual pandemics that have claimed the lives of millions. Their very high seasonal variation makes effective vaccination and environment control very challenging [ 1 – 5 ]. The twenty-first century pandemic resulted from an influenza A (H1N1) virus that quickly spread worldwide and was reported in 214 countries in various states, claiming many victims [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive electrochemical biosensor based on redox - active monolayer for detection of anti-hemagglutinin antibodies against swine-origin influenza virus H1N1 in sera of vaccinated mice

et al. 2018

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BackgroundIn this work, we report an electrochemical biosensor for the detection of anti-hemagglutinin antibodies against the swine virus H1N1 present in mice sera immunized with mixture of His6-H1 HA in monomeric and oligomeric form. The oriented immobilization of the recombinant His-tagged hemagglutinin (His6-H1 HA) consists of: (i) formation of a mixed layer of 4-mercaptobutanol (MBT) and the thiol derivative of dipyrromethene (DPM); (ii) complexation of Cu (II) by DPM; (iii) immobilization of His6-H1 HA via coordination bonds between Cu (II) sites from DPM–Cu (II) complex and imidazole nitrogen atoms of a histidine tag; (iv) filling free spaces with bovine serum albumin. The interactions between recombinant His6- H1 HA covalently attached to the electrode surface and the anti-hemagglutinin H1 antibodies present in mice sera were explored with Osteryoung square-wave voltammetry.ResultsThis analytical device was able to detect the antibodies present in vaccinated mice sera diluted from 1 × 109 to 1 × 108 fold.ConclusionsThe unprecedented sensitivity of described biosensor is much better than widely use ELISA test and other analytical methods for determination of antibodies against the influenza A viruses. It has been proved that redox active DPM-Cu (II) monolayer is a universal platform suitable for stable and oriented immobilization of any His-tagged sensing elements. Thus, this universal layer could be a base of numerous analytical devices suitable for detection of antibodies against different viruses.

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Section: Introductionmentioning

confidence: 99%

Highly sensitive electrochemical biosensor based on redox - active monolayer for detection of anti-hemagglutinin antibodies against swine-origin influenza virus H1N1 in sera of vaccinated mice

et al. 2018

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“…7 Continuous antigenic dri and antigenic translation of viral surface glycoproteins make it a major factor in the unpredictable effects of inuenza vaccines. [8][9][10] Vaccine protection is not effective enough to provide reliable protection for humans. [11][12][13] At present, due to the rising resistance of inuenza virus to existing anti-inuenza drugs, we urgently need to nd new antiviral drugs.…”

Section: Introductionmentioning

confidence: 99%

The inhibition of H1N1 influenza induced apoptosis by sodium selenite through ROS-mediated signaling pathways

Gong

et al. 2020

RSC Adv.

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“…H3N2 viruses are the most antigenically variable and frequent drift variants emerge (Both et al 1983;DeDiego et al 2016a;Allen and Ross 2018). H1N1 is relatively more stable antigenically, although drift still occurs (Carrat and Flahault 2007;Clark et al 2017a;Suptawiwat et al 2018). Influenza B viruses have been the most antigenically stable, although the reasons for these differences in antigenic stability among influenza A and B viruses are not known.…”

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confidence: 99%

Immunity to Influenza Infection in Humans

Topham

DeDiego

Nogales

et al. 2019

Cold Spring Harb Perspect Med

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This review discusses the human immune responses to influenza infection with some insights from studies using animal models, such as experimental infection of mice. Recent technological advances in the study of human immune responses have greatly added to our knowledge of the infection and immune responses, and therefore much of the focus is on recent studies that have moved the field forward. We consider the complexity of the adaptive response generated by many sequential encounters through infection and vaccination.

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H1N1 seasonal influenza virus evolutionary rate changed over time

Cited by 4 publications

References 26 publications

Highly sensitive electrochemical biosensor based on redox - active monolayer for detection of anti-hemagglutinin antibodies against swine-origin influenza virus H1N1 in sera of vaccinated mice

Highly sensitive electrochemical biosensor based on redox - active monolayer for detection of anti-hemagglutinin antibodies against swine-origin influenza virus H1N1 in sera of vaccinated mice

The inhibition of H1N1 influenza induced apoptosis by sodium selenite through ROS-mediated signaling pathways

Immunity to Influenza Infection in Humans

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