The inhibition of H1N1 influenza induced apoptosis by sodium selenite through ROS-mediated signaling pathways

Gong, Guifang; Li, Yinghua; He, Kunyan; Yang, Qiumei; Guo, Min; Xu, Tiantian; Wang, Changbing; Zhao, Mingqi; Chen, Yi; Du, Miaomiao; Li, Bingyuan; Huang, Yanqing; Zhu, Bing

doi:10.1039/c9ra09524a

Cited by 13 publications

(14 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Viral infection is associated with oxidative stress through the induction of enzymes that produce harmful reactive oxygen species (ROS) ( 9 ). There is an increase of ROS in a cell model infected with the influenza AH1N1 RNA virus ( 35 ). Sodium selenite decreases the production of ROS and the induced cell apoptosis in these infected cells ( 36 ).…”

Section: Mechanisms By Which Sodium Selenite Could Act In Rna Virus Imentioning

confidence: 99%

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Hiffler¹,

Rakotoambinina

2020

Front. Nutr.

104

View full text Add to dashboard Cite

SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly. Selenium (Se), a natural trace element, has a key and complex role in the immune system. It is well-documented that Se deficiency is associated with higher susceptibility to RNA viral infections and more severe disease outcome. In this article, we firstly present evidence on how Se deficiency promotes mutations, replication and virulence of RNA viruses. Next, we review how Se might be beneficial via restoration of host antioxidant capacity, reduction of apoptosis and endothelial cell damages as well as platelet aggregation. It also appears that low Se status is a common finding in conditions considered at risk of severe COVID-19, especially in the elderly. Finally, we present a rationale for Se use at different stages of COVID-19. Se has been overlooked but may have a significant place in COVID-19 spectrum management, particularly in vulnerable elderly, and might represent a game changer in the global response to COVID-19.

show abstract

Section: Mechanisms By Which Sodium Selenite Could Act In Rna Virus Imentioning

confidence: 99%

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Hiffler¹,

Rakotoambinina

2020

Front. Nutr.

104

View full text Add to dashboard Cite

show abstract

“…Other research on the anti-influenza A virus showed three compounds with antiviral activity related to the efficacy of Flos Trollii and antiviral activities of compounds isolated from Pinus densiflora (pine tree) in cell culture [13,14]. Recent research demonstrated the antiviral activity of ATR-002 and selenium supplementation against influenza A virus in the cell culture [15,16]. Also, Yejin Jang and his teammates showed that lambda-carrageenan (λ-CGN) could be a promising and preventive agent for several respiratory infections, especially influenza A virus and SARS-CoV-2 [17].…”

Section: D Cell Culture Application For Sars-cov Mers-cov H1n1 and Sars-cov-2mentioning

confidence: 99%

Application of Cell Culture Models in Studying Viral Diseases (SARS, H1N1 Flu, MERS, COVID-19): A Review

Alavi¹,

Tajvar²,

Hadjizadeh³

2021

JICOA

View full text Add to dashboard Cite

The emergence of recent viral outbreaks, especially the COVID-19 pandemic, and the resulting global mortality and damage has created an urgent need to accelerate the identification, prevention, and treatment of these viral diseases. Due to the limitations in the use of humans, and animal models in terms of time, costs, metabolism differences and ethical issues, in vitro models have become essential in virology research. In the present review, we collected the application of several used cell culture models in studies on four pathogenic viruses - severe acute respiratory syndrome coronavirus (SARS-CoV), influenza A virus (H1N1), middle east respiratory syndrome coronavirus (MERS-CoV), and 2019 novel coronavirus (SARS-CoV-2). These models included, 2D and 3D cell culture (organoids, microfluidic-chips, and bioprinted models). A collection of existing research on these viruses can help fight against the SARS-CoV-2 virus and speed it up against future emerging viruses. Moreover, it can show the shortcomings of in vitro models in virology studies that have been performed to date and provide researchers with new ideas for developing models that are more efficient to deal with similar viral outbreaks.

show abstract

“…Viral infection is associated with oxidative stress through the induction of enzymes that produce harmful reactive oxygen species (ROS) (9). There is an increase of ROS in a cell model infected with the influenza AH1N1 RNA virus (35). Sodium selenite decreases the production of ROS and the induced cell apoptosis in these infected cells (36).…”

Section: Decrease In Viral-induced Cell Apoptosismentioning

confidence: 99%

Selenium and RNA virus interactions: Potential implications for SARS-CoV-2 infection (COVID-19)

Hiffler¹,

Rakotoambinina²

2020

Preprint

View full text Add to dashboard Cite

SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly. Selenium, a natural trace element, has a key and complex role in the immune system. It is well documented that Selenium deficiency is associated with higher susceptibility to RNA viral infections and more severe disease outcome. In this article, we firstly present evidence on how Selenium deficiency promotes mutations, replication and virulence of RNA viruses. Next, we review how Selenium might be beneficial via restoration of host antioxidant capacity, reduction of apoptosis and endothelial cell damages as well as platelet aggregation. It also appears that low Selenium status is a common finding in conditions considered at risk of severe COVID-19, especially in the elderly. Finally, we present a rationale for Selenium use at different stages of COVID-19. Selenium has been overlooked but may have a significant place in COVID-19 management, particularly in vulnerable elderly, and might represent a game changer in the global response to COVID-19.

show abstract

The inhibition of H1N1 influenza induced apoptosis by sodium selenite through ROS-mediated signaling pathways

Abstract: The high variability of influenza viruses has made it more difficult for people to cope with influenza.

Cited by 13 publications

References 54 publications

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Application of Cell Culture Models in Studying Viral Diseases (SARS, H1N1 Flu, MERS, COVID-19): A Review

Selenium and RNA virus interactions: Potential implications for SARS-CoV-2 infection (COVID-19)

Contact Info

Product

Resources

About