Helicobacter pylori in metabolic related diseases

Rizzatti, Gianenrico; Matteo, Maria Valeria; Ianiro, Gianluca; Cammarota, Giovanni; Franceschi, Francesco; Gasbarrini, Antonio

doi:10.23736/s1121-421x.18.02490-x

Cited by 11 publications

(3 citation statements)

References 58 publications

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“…The evidence on the role of H pylori infection in the pathogenesis of metabolic‐related diseases is increasing . Chen et al performed a community‐based study on the prevalence of H pylori in patients with obesity showing a higher BMI in infected patients compared to noninfected.…”

Section: Metabolic Syndrome and Diabetes Mellitusmentioning

confidence: 99%

Review:Helicobacter pyloriand extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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Section: Metabolic Syndrome and Diabetes Mellitusmentioning

confidence: 99%

Review:Helicobacter pyloriand extragastric diseases

2019

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“…Helicobacter pylori ( H.pylori ) is related to gastrointestinal illnesses such as chronic gastritis, gastric ulcer and gastric carcinomas [1]. It is believed to be associated with infection-initiated inflammatory response, which is characterized by altered cytokine production in gastric epithelial cells [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Celastrus orbiculatus in inhibiting Helicobacter pylori induced inflammatory response by regulating epithelial mesenchymal transition and targeting miR-21/PDCD4 signaling pathway in gastric epithelial cells

Zhu¹,

Liu

et al. 2019

BMC Complement Altern Med

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Background The extract of Celastrus orbiculatus (COE) have been studied for anti- Helicobacter pylori ( H. pylori ) activity and anti-cancer effects in vitro and in vivo. However, the molecular mechanism by which COE inhibits H. pylori -induced inflammatory response has not been fully elucidated so far. Methods The effects of COE on viability, morphological changes, inflammatory cytokine secretion, protein and mRNA expression were analyzed by MTT assay, enzyme-linked immunosorbent assay (ELISA), immunofluorescence, western blot and real-time PCR (RT-PCR), respectively. The methylation level of programmed cell death 4 (PDCD4) promoter was investigated by methylation-specific PCR. (MSP) . Results COE effectively inhibited the H.pylori -induced inflammatory response by regulating epithelial-mesenchymal transition (EMT). The methylation level of PDCD4 promoter was suppressed by COE, which increased the expression ofPDCD4. Moreover, COE could inhibit microRNA-21 (miR-21) expression, as shown by an enhancement of its target gene PDCD4. Furthermore, both miR-21 over-expression and PDCD4 silencing attenuated the anti-inflammatory effect. of COE. Conclusions COE inhibits H. pylori induced inflammatory response through regulating EMT, correlating with inhibition of miR-21/PDCD4 signal pathways in gastric epithelial cells. Electronic supplementary material The online version of this article (10.1186/s12906-019-2504-x) contains supplementary material, which is available to authorized users.

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“…However, these suggestions are supported by small data and evidence is still lacking. [10][11][12][13][14][15] Nonetheless, H. pylori infection has been inversely associated to different rates of asthma and allergies. 16 Currently, H. pylori prevalence is still high, showing different rates worldwide: in Europe it is lower in Northern countries (ranging from 31.7% among blood donors in Netherlands to 84.2% in Portugal).…”

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confidence: 99%

Diagnosis of Helicobacter pylori infection: a look into molecular aspects of urea breath test

Marinoni¹,

Ribaldone²,

Rosso³

et al. 2019

Minerva Biotecnol

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Helicobacter pylori (H. pylori) is a bacterium that selectively colonizes gastric epithelium in more than 50% people over the world. The infection is usually acquired in early childhood and rarely resolved spontaneously; transmission is mostly person to person, and occurs by fecal-oral or oraloral modality. Diagnosis and antibiotic treatment may lead to eradication of H. pylori, improving the prevention and the outcome of gastric and extragastric diseases. Many tests are currently available for the diagnosis of H. pylori infection and the choice depends on several clinical aspects including symptoms, age, indications for testing, concomitant medications and comorbidities.Invasive tests (i.e. endoscopy with histologic assessment) are considered the gold standard, but they are expensive and should be performed only in an appropriate context. The most common noninvasive tests are urea breath test (UBT), stool antigens test and serology. UBT is non-invasive, quick, safe, accurate and cheap. This test is performed mainly with 13 C and is based on the presence of H. pylori urease, an enzyme that converts urea (labelled with an isotope) into CO2. Labelled CO2 is then exhaled and measured by dedicated spectrophotometers. This review analyses with special emphasis UBT, focusing on its molecular aspects.

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Helicobacter pylori in metabolic related diseases

Cited by 11 publications

References 58 publications

Review:Helicobacter pyloriand extragastric diseases

Review:Helicobacter pyloriand extragastric diseases

Effect of Celastrus orbiculatus in inhibiting Helicobacter pylori induced inflammatory response by regulating epithelial mesenchymal transition and targeting miR-21/PDCD4 signaling pathway in gastric epithelial cells

Diagnosis of Helicobacter pylori infection: a look into molecular aspects of urea breath test

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