JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

Maia, Lucas de Lima; Peterle, Gabriela Tonini; Santos, Marcelo dos; Trivilin, Leonardo Oliveira; Mendes, Suzanny Oliveira; Oliveira, Mayara Mota de; Santos, Joaquim Gasparini dos; Stur, Elaine; Agostini, Lidiane Pignaton; Couto, Cinthia Vidal Monteiro da Silva; Dalbó, Juliana; Assis, Arícia Leone Evangelista Monteiro de; Archanjo, Anderson Barros; Mercante, Ana Maria da Cunha; López, Rossana Verónica Mendoza; Nunes, Fábio Daumas; Carvalho, Marcos Brasilino de; Tajara, Eloíza H.; Louro, Iúri Drumond; Silva, Adriana Madeira Álvares da

doi:10.1371/journal.pone.0194884

Cited by 21 publications

(13 citation statements)

References 44 publications

(55 reference statements)

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“…Based on the univariate Cox regression analysis, we assigned the SIG12 score of the 12 genes as follows: SIG12 score = (0.324 × expression value of ADM) + (−0.379 × expression value of CYSLTR1) + (0.353 × expression value of DDIT4) + (−0.326 × expression value of DOCK8) + (0.29 × expression value of ENO2) + (−0.28 × expression value of FCER1A) + (−0.286 × expression value of IL17A) + (−0.328 × expression value of IZUMO4) + (−0.273 × expression value of MMP25) + (−0.362 × expression value of P2RY14) + (0.292 × expression value of RBP4) + (−0.299 × expression value of ZNF252P‐AS1). The known or putative functions and clinical relevance are described in Table .…”

Section: Resultsmentioning

confidence: 99%

A gene signature associated with prognosis and immune processes in head and neck squamous cell carcinoma

Bai

Zhang

et al. 2019

Head & Neck

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Background Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis that has not significantly improved in the past several decades. A prognostic‐related signature was needed. Methods The Cancer Genome Atlas and GSE41613 databases were downloaded as a training and validation set, respectively. We identified 12 genes that demonstrated progression and prognostic value, and then, a gene signature was constructed. Results This classification could reflect distinct characteristics, phenotypically and molecularly, among HNSCC tumors. It could stratify patients with significantly different survival rates (median survival: 2083 days vs 927 days; P = 3.85E‐08) in the training cohort and validation cohort (P = 0.007) and was significantly involved in immune/inflammatory response and tumor progression processes. Conclusions This bioinformatics‐based signature suggested the presence of two distinct populations of patients with HNSCC with distinguishable phenotypic characteristics and clinical outcomes and might provide insight for new types of immune therapy.

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Section: Resultsmentioning

confidence: 99%

A gene signature associated with prognosis and immune processes in head and neck squamous cell carcinoma

Bai

Zhang

et al. 2019

Head & Neck

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“…In addition, H3K79Me3 is one of the histone modifications of interest due to controlling epithelial-to-mesenchymal (EMT) (62) and the stemness of certain cells (63). H3K9Me1 has exhibited capacity for liver cancer formation (64) and was found to be a prognosis marker in oral cancer and oropharyngeal squamous cell carcinoma (65).…”

Section: Discussionmentioning

confidence: 99%

Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide

Maiuthed

Prakhongcheep

Chanvorachote

2020

Cancer Genomics Proteomics

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Background/Aim: Nitric oxide (NO) is recognized as an important biological mediator that exerts several human physiological functions. As its nature is an aqueous soluble gas that can diffuse through cells and tissues, NO can affect cell signaling, the phenotype of cancer and modify surrounding cells. The variety of effects of NO on cancer cell biology has convinced researchers to determine the defined mechanisms of these effects and how to control this mediator for a better understanding as well as for therapeutic gain. Materials and Methods: We used bioinformatics and pharmacological experiments to elucidate the potential regulation and underlying mechanisms of NO in non-small a lung cancer cell model. Results: Using microarrays, we identified a total of 151 NO-regulated genes (80 upregulated genes, 71 down-regulated genes) with a strong statistically significant difference compared to untreated controls. Among these, the genes activated by a factor of more than five times were: DCBLD2,

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“…EDNRB promoter methylation, which is associated with the histologic diagnosis of premalignancy and the presence of malignancy, may be a promising marker for the early detection of premalignant lesions in oral cavity cancer [39]. The ADM gene, which plays a role in carcinogenesis by regulating cellular processes including proliferation, differentiation, migration, growth, immunosuppression and hypoxia, increases lymph node metastasis risk in oral and oropharynx cancer [40]. Increased BTC mRNA expression is associated with worse survival in HNSCC [41].…”

Section: Genetic Alterations and Gsea Analysis In The High-risk Groupsmentioning

confidence: 99%

A novel comprehensive immune-related gene signature as a promising survival predictor for head and neck squamous cell carcinoma

Fang

Chen

Liao

et al. 2020

Preprint

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Background: Head and neck squamous cell carcinoma (HNSCC), the most frequent subtype of head and neck cancer, continues to have a poor prognosis with no improvement. Growing evidence has demonstrated that the immune system plays a crucial role in the development and progression of HNSCC. The goal of our study was to develop an immune-related signature for accurately predicting the survival of HNSCC patients. Methods: Gene expression profiles were established from a total of 546 HNSCC and normal tissues to establish a training set and 83 HNSCC tissues for a validation set. Differentially expressed prognostic immune genes were identified by univariate Cox regression analysis and a corresponding network of differentially expressed transcription factors (TFs) were identified using Cytoscape. The immune-related gene signature was established and validated by univariate Cox regression analysis, least absolute shrinkage and selector operation (LASSO), and multivariate Cox regression analyses. In addition, the prognostic value of the immune-related signature was analyzed by survival and Cox regression analysis. Finally, the correlation between the immune-related signature and the immune microenvironment was established.Results: In this study, the TF-mediated network revealed that Foxp3 plays a central role in the regulatory mechanism of most immune genes. A prognostic signature based on 10 immune-related genes, which divided patients into high and low risk groups, was developed and successfully validated using two independent databases. Our prognostic signature was significantly related to worse survival and predicted prognosis in patients with different clinicopathological factors. A nomogram including clinical characteristics was also constructed for accurate prediction. Furthermore, it was determined that our prognostic signature may act as an independent factor for predicting the survival of HNSCC patients. ROC analysis also revealed that our signature had superior predictive value compared with TNM stage. As for the immune microenvironment, our signature showed a positive correlation with activated mast cells and M0 macrophages, a negative correlation with Tregs, and immune checkpoint molecules PD-1 and CLTA-4. Conclusions: Our study established an immune-related gene signature, which not only provides a promising biomarker for survival prediction, but may be evaluated as an indicator for personalized immunotherapy in patients with HNSCC.

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JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

Cited by 21 publications

References 44 publications

A gene signature associated with prognosis and immune processes in head and neck squamous cell carcinoma

A gene signature associated with prognosis and immune processes in head and neck squamous cell carcinoma

Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide

A novel comprehensive immune-related gene signature as a promising survival predictor for head and neck squamous cell carcinoma

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