Relation of Platelet Indexes to Platelet Reactivity and Periprocedural Myocardial Infarction in Patients Who Underwent Percutaneous Coronary Angioplasty

Ricottini, Elisabetta; Mangiacapra, Fabio; Nusca, Annunziata; Melfi, Rosetta; Cavallari, Ilaria; Miglionico, Marco; Gallo, Paolo; Pozzilli, Paolo; Sciascio, Germano Di

doi:10.1016/j.amjcard.2018.01.013

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…Что касается связи MPV c ВОРТ у пациентов с ОКС, то литературные данные противоречивы. Часть исследований демонстрирует подобную связь [26,27], другими исследованиями связи MPV с ВОРТ не обнаружено [28,29]. Наше исследование показало, что MPV значимо не различался в подгруппах с разным ответом на клопидогрел, однако данный показатель вошел в обе модели для прогнозирования ВОРТ и НОРТ.…”

Section: рисунок 2 -Roc-кривая модели; Auc -площадь под Roc-кривой Fi...unclassified

“…В нашем исследовании более высокие значения PDW ассоциировались с ВОРТ, данный показатель вошел в модель прогнозирования ВОРТ. Хотя есть работы, в которых связи PDW с ВОРТ на клопидогрел и ацетилсалициловую кислоту не обнаружены [29].…”

Section: рисунок 2 -Roc-кривая модели; Auc -площадь под Roc-кривой Fi...unclassified

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Determinants of High and Low Platelet Residual Reactivity on Day 1-2 of Myocardial Infarction When Taking Clopidogrel

Pronko,

Snezhitskiy,

Kapytski

2023

Journal GrGMU

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The aim of the study was to determine the clinical and laboratory factors that determine high and low platelet reactivity in patients taking clopidogrel on day 1-2 of myocardial infarction (MI). Material and Methods. A total of 405 patients (322 men and 83 women) with MI aged 31 to 74 years were examined. Group 1 included patients with low residual platelet reactivity (LRPR) – 89 people, group 2 consisted of patients with optimal platelet reactivity (OPR) – 223 people, group 3 was composed of patients with high residual platelet reactivity (HRPR) – 93 people. Platelet aggregation was assessed on a Multiplate impedance aggregometer (Germany) with several aggregation inducers. A blood test and a study of morphometric parameters of platelets were performed by the cytoflow method on an automated hematology analyzer Sysmex XS-500i (Japan). The study of the level of soluble CD40 ligand (sСD40L) and sP-selectin was performed in 140 patients, von Willebrand factor (VWF) and endothelin-1 were assessed in 150 people on the enzyme immunoassay analyzer Sunrise (TECAN, Austria) using Fine Biotech kits (China). All studies were performed upon admission to the hospital on day 1-2 of MI (at least 12 hours after the administration of a loading dose of clopidogrel). Results. A one-way linear regression analysis identified the following factors that independently affect the value of the ADP-test: age (β=-0.21, 95% CI: -0.42 – -0.0095; p=0.04); total cholesterol (β=1.4, 95% CI: 0.26–2.56; p=0.04); white blood cell count (β= 0.57, 95% CI: 0.003–1.14; p=0.049); hemoglobin (β=-0.16, 95% CI: -0.27 – -0.044; p=0.0067); platelet count (β=1.4, 95% CI: 0.26 – 2.56; p=0.04); PCT (β=76.8, 95% CI: 41.5 – 112.1; p=0.000024); TRAP-test (β=0.4, 95% CI: 0.33–0.46; p<0.000001); CD40L (β=0.044, 95% CI: 0.013–0.074; p=0.005); sP-selectin (β=2.3, 95% CI: 0.63 – 3.97; p=0.007); VWF (β=0.06, 95% CI: 0.016 – 0.11; p=0.0085). To determine the probability of HRPR developing a binary logistic regression model was constructed based on the observational data of a sample of 398 patients, which included the following indicators: age, white blood cell count, mean platelet volume (MPV) and platelet distribution width (PDW) values, results of TRAP-test and the level of creatinine. At the probability cut-off p=0.4746, the sensitivity of the constructed model was 74.2%, specificity - 74.1%, classification accuracy – 74.1%, the area under the ROC-curve – 0.795 (CI: 0.745 – 0.844). To determine the probability of developing LRPR, a binary logistic regression model was constructed based on the observational data of 143 patients, which included the following indicators: the number of leukocytes, MPV and TRAP-test values, fibrinogen and VWF levels. With a probability cut-off p=0.5589, the sensitivity of this model was 84.6%, specificity – 77.8%, classification accuracy – 79.0%, the area under the ROC-curve – 0.826 (CI: 0.747 – 0.905). Conclusion. On days 1-2 of MI, 22% of patients with an excessive response to clopidogrel and 23% with an insufficient response to clopidogrel were identified. The determinants of HRPR are age, white blood cell count, MPV, PDW, TRAP-test and creatinine levels. The determinants of LRPR are white blood cell count, MPV values, spontaneous platelet aggregation, detected by the TRAP-test, the level of fibrinogen and VWF.

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Section: рисунок 2 -Roc-кривая модели; Auc -площадь под Roc-кривой Fi...unclassified

Determinants of High and Low Platelet Residual Reactivity on Day 1-2 of Myocardial Infarction When Taking Clopidogrel

Pronko,

Snezhitskiy,

Kapytski

2023

Journal GrGMU

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“…Recently, the absolute blood cell counts or the ratios between them have received increased clinical attention as inflammatory markers [6][7][8][9]. The predictive value of the platelet-to-lymphocyte/neutrophil-to-lymphocyte ratio (PLR/NLR) and the systemic immune-inflammation index (platelet count × NLR) were demonstrated to affect the clinical outcomes of STEMI patients [8][9][10][11][12][13]. However, few studies have focused on the [14].…”

Section: Introductionmentioning

confidence: 99%

Association between Platelet to Neutrophil Ratio (PNR) and Clinical Outcomes in STEMI Patients after Successful pPCI: A Secondary Analysis Based on a Cohort Study

Wang

Qing

Wang

et al. 2022

Cardiovascular Therapeutics

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Purpose. This study was aimed at investigating whether the platelet-to-neutrophil ratio (PNR) is independently related to the prognosis of patients with ST-elevation myocardial infarction (STEMI) after successful primary percutaneous coronary intervention (pPCI). Methods. This was a secondary analysis of data retrieved from the DATADRYAD database, which was a prospective cohort study. A total of 464 STEMI patients who underwent successful pPCI were recruited between January 2010 and October 2014. The target-independent variable, PNR, was measured at the baseline. The dependent variable in the current study was the occurrence of major adverse cardiovascular events (MACEs) during the 30-month follow-up. Results. Two patients were excluded from the final analysis because their platelet counts were unavailable. The average age of the 462 participants was 63 ± 11.92 years, and approximately 76.6% were male. After adjusting for age, sex, anterior wall myocardial infarction (MI), history of MI, apelin-12, apelin-12 change rate, left ventricular end-diastolic diameter, peak cardiac troponin I, pathological Q wave, Killip classification grade, fasting blood glucose, albumin, GENSINI score, and estimated glomerular filtration rate, a nonlinear relationship was found between the PNR and MACEs in the included cohort. The threshold value of the PNR for MACEs was 23.1. Over this cutoff value, the incidence rate of MACEs increased by 43% per 10-unit change in PNR (95% CI: 1.16–1.75, p = 0.0006 ). Conclusion. There was a threshold relationship between PNR and MACEs in patients with STEMI who underwent successful pPCI. The incidence of MACEs was positively associated with the PNR when the PNR exceeded 23.1.

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Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention

Bressi

Mangiacapra

Ricottini

et al. 2018

J. of Cardiovasc. Trans. Res.

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Relation of Platelet Indexes to Platelet Reactivity and Periprocedural Myocardial Infarction in Patients Who Underwent Percutaneous Coronary Angioplasty

Cited by 7 publications

References 32 publications

Determinants of High and Low Platelet Residual Reactivity on Day 1-2 of Myocardial Infarction When Taking Clopidogrel

Determinants of High and Low Platelet Residual Reactivity on Day 1-2 of Myocardial Infarction When Taking Clopidogrel

Association between Platelet to Neutrophil Ratio (PNR) and Clinical Outcomes in STEMI Patients after Successful pPCI: A Secondary Analysis Based on a Cohort Study

Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention

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