Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention

Bressi, Edoardo; Mangiacapra, Fabio; Ricottini, Elisabetta; Cavallari, Ilaria; Colaiori, Iginio; Gioia, Giuseppe Di; Creta, António; Capuano, Marialessia; Viscusi, Michele Mattia; Sciascio, Germano Di

doi:10.1007/s12265-018-9829-6

Cited by 38 publications

(33 citation statements)

References 30 publications

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“…Investigators reported in several studies that plasma markers of inflammation (increased WBC and neutrophil counts) were associated with a higher risk of CAD [7]. In addition, a low blood lymphocyte count indicates reduced immunity and has been associated with cardiovascular complications in patients with CAD [23,24]. In the present study, the WBC and lymphocyte counts were higher and platelet count was lower in the patient group than in the control (P = 0.001, P < 0.001, P = 0.041, respectively).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for coronary artery disease in young patients with stable angina pectoris

Duran¹,

Elçik²,

Murat³

et al. 2019

Turk J Med Sci

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Background/aim: We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP). Materials and methods:A total of 571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD.Results: Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients. Conclusion:Contrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict the presence of CAD in a young population with SAP.

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Section: Discussionmentioning

confidence: 99%

Risk factors for coronary artery disease in young patients with stable angina pectoris

Duran¹,

Elçik²,

Murat³

et al. 2019

Turk J Med Sci

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“…As the world's ageing population increases, ST-segment elevation myocardial infarction (STEMI) incidence is expected to increase to be the most common and fatal cardiac emergency (1). Acute myocardial infarction (AMI) is often caused by the interruption of coronary artery blood flow and myocardial ischemic necrosis resulting from decreased stability of coronary atherosclerotic plaque, ulcer, rupture and other thrombosis (2). Therefore, early, rapid and complete opening of the infarcted artery is key to improving the prognosis of patients with STEMI (2,3).…”

Section: Introductionmentioning

confidence: 99%

“…Acute myocardial infarction (AMI) is often caused by the interruption of coronary artery blood flow and myocardial ischemic necrosis resulting from decreased stability of coronary atherosclerotic plaque, ulcer, rupture and other thrombosis (2). Therefore, early, rapid and complete opening of the infarcted artery is key to improving the prognosis of patients with STEMI (2,3). Percutaneous coronary intervention (PCI) is a non-surgical method used in extensive myocardial reperfusion therapy (4).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST‑segment elevation myocardial infarction after percutaneous coronary intervention

et al. 2020

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The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these methods can better predict the clinical adverse outcome of patients with ST-segment elevation myocardial infarction (STEMI), have not been previously examined. Therefore, the aim of the present study was to investigate whether the combination of GRACE risk score and MPVLR is a good predictor of a 30-day major adverse cardiovascular events (MACE) in patients with STEMI. A total of 464 patients with STEMI undergoing percutaneous coronary intervention (PCI) were enrolled, and divided into four groups based on the optimal cutoff values for GRACE score and MPVLR. GRACE score and MPVLR levels were separately recorded during admission. Spearman's rank correlation analysis showed a positive correlation between GRACE score and MPVLR (ρ=0.304; P<0.001). Both GRACE score [hazard ratio (HR), 1.706; 95% CI, 1.435-3.058; P<0.001] and MPVLR level (HR, 1.668; 95% CI, 1.202-2.170; P<0.001) were found to be independent predictors of a 30-day MACE. Additionally, the high MPVLR + high GRACE score group of patients had an HR of 2.455 (95% CI, 1.736-3.188) for a 30-day MACE, when using the low MPVLR + low GRACE score group as a reference. Based on the area under the curve, MPVLR combined with GRACE scores achieved an improved performance in differentiating angiographic no-reflow during a 30-day MACE, compared with individual MPVLR and GRACE scores. Therefore, the present results suggested that the GRACE score may be positively correlated with MPVLR and that their combination accurately predicted the occurrence of short-term MACE in patients with STEMI after PCI.

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“…However, even when WBC is within normal limits, an increased neutrophil to lymphocyte ratio (NLR) may indicate inflammation and inflammation-related pathologies [4]. The NLR has been used in the evaluation and prognostication of various diseases, including coronary artery diseases, malignancies, rheumatologic diseases, and neurological diseases [5][6][7][8][9][10][11][12]. Few studies have investigated the value of this marker in the evaluation of migraineurs [8,10,13].…”

Section: Introductionmentioning

confidence: 99%

May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

Önder

Deliktas

2020

J Neurol Res

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Background: We aimed to investigate the possible association between the value of neutrophil to lymphocyte ratio (NLR) and some specific features of migraine. Methods:We have included initially all the patients with migraine who applied to our neurology clinic in Yozgat City Hospital during December 2019 and agreed to participate in this study. The demographic and clinical characteristics including migraine subtype (episodic/chronic), headache frequency per month, headache characteristics of all patients were interrogated. Besides, the presence of fibromyalgia (FM) and chronic fatigue syndrome (CFS) was also noted. The severity of migraine was assessed using the headache impact test (HIT-6) and the severity of chronic fatigue was assessed using the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale. A hemogram was performed upon admission to the clinic. The patients with migraine attacks during the clinic visits were excluded from the study.Results: Ultimately, 52 migraineurs were included in this study. The mean age was 37.34 ± 11.80 and the female/male (F/M) ratio was 49/3. Thirty-six patients (69%) were diagnosed with episodic migraine (EM), and 16 of them (31%) were diagnosed with chronic migraine (CM). The results of the comparative analyses between EM and CM groups showed that the NLR did not differ between groups. To evaluate the possible association of the NLR with other clinical parameters, additional comparative analyses evaluating the presence of FM, CFS, cognitive symptoms and tinnitus were also conducted, which showed no significant differences. The results of the correlation analyses to evaluate the possible associations between the NLR value and other clinical parameters were also unremarkable. Conclusions:We suggest that the NLR cannot be a specific marker to be used in the differential diagnosis or prediction of any features of migraines during the interictal period. However, in light of the previous reports, the utility of this value in the differentiating of migraine attacks from other causes of headache attacks can be investigated in future related studies.

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Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention

Cited by 38 publications

References 30 publications

Risk factors for coronary artery disease in young patients with stable angina pectoris

Risk factors for coronary artery disease in young patients with stable angina pectoris

Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST‑segment elevation myocardial infarction after percutaneous coronary intervention

May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

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