Appetite hormones in children and adolescents with cancer: a systematic review of observational studies

Fayh, Ana Paula Trussardi; Bezerra, Agnes Denise de Lima; Friedman, Rogério

doi:10.20960/nh.1221

Cited by 4 publications

(4 citation statements)

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“… 27 39 40 Good nutritional status enables patients to better cope with intensive cancer treatment regimens. 41 Patients with BC with high levels of social support have lower severity of chemotherapy-related symptoms. 42 In addition, interventions can be based on QOL predictors of BC, such as chronotype, the level of QOL before chemotherapy and depression.…”

Section: Discussionmentioning

confidence: 99%

“…Past studies reported that women who are malnourished have a serious negative impact on QOL,34 and nutritional intervention can improve the symptoms of nausea, vomiting, and loss of appetite in patients with BC, and exercise can reduce fatigue and improve the physical quality of patients with BC 27 39 40. Good nutritional status enables patients to better cope with intensive cancer treatment regimens 41. Patients with BC with high levels of social support have lower severity of chemotherapy-related symptoms 42.…”

Section: Discussionmentioning

confidence: 99%

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Quality of life in patients with breast cancer with neoadjuvant chemotherapy: a systematic review

et al. 2022

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ObjectivesThe aims of this systematic review were to assess the impact of neoadjuvant chemotherapy (NAC) on breast cancer (BC) patients’ quality of life (QOL), to compare the different regimens of NAC on BC patients’ QOL, to compare NAC versus adjuvant chemotherapy on BC patients’ QOL and to identify predictors of QOL on patients with BC receiving NAC.DesignThe design used Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesCinahl, Embase, Pubmed, Scopus, Web of Science, Cochrane library and PsycINFO were searched through 27 December 2021.Eligibility criteria for selecting studiesThe inclusion criteria were included: patients with BC receiving NAC, outcome measures related to QOL and published in English. The exclusion criteria were included: duplicates or overlapping participants, not original research, data or full text not available and qualitative study.Data extraction and synthesisTwo independent reviewers used standardised methods to search, screen and code included studies. The risk of bias in individual studies was evaluated with Cochrane collaboration’s tool for assessing risk bias, Newcastle Ottawa Score or Joanna Briggs Institute Critical Appraisal tool. This systematic review performs narrative synthesis based on several different themes.ResultsThe initial search resulted in 2994 studies; 12 of these studies fulfilled inclusion criteria. There was no significant difference in the QOL of BC before and after NAC, but patients experienced adverse reactions and depression during chemotherapy. Different regimens of NAC have different effects on patients’ QOL. Patients with NAC had more severe physical discomfort than those with adjuvant chemotherapy. However, BC patients’ QOL can be improved by intervening on social or family support, and these predictors, including chronotype, QOL before NAC and depression.ConclusionsMore original research is needed in future to understand the profile and predictors of QOL in patients with BC on NAC, which will help clinicians and patients make decisions and deal with NAC-related issues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quality of life in patients with breast cancer with neoadjuvant chemotherapy: a systematic review

et al. 2022

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“…Alteração nos níveis dos hormônios relacionados à regulação da ingestão alimentar, como a grelina e leptina, foram relatados em uma variedade de cânceres. (15) Os efeitos colaterais do tratamento incluem, além da alteração nos hábitos alimentares, sentimentos de medo e angústia, estabelecendo uma relação direta entre não desejar seguir corretamente a terapêutica proposta e a possibilidade de morrer. Ou seja, o estigma da morte imposto pela doença permeia as vidas dos acometidos.…”

Section: Discussionunclassified

Mudanças ocorridas após diagnóstico e tratamento do câncer na perspectiva da criança

Marcon¹,

Lino²,

Silva³

et al. 2020

Revista Da Sociedade Brasileira De Enfermeiros Pediatras

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“…However, very few studies have evaluated alterations in ghrelin and leptin during chemotherapy in different types of cancer, and these discrepant results may be due to the different treatments adopted. 12 Given the risk of malnutrition among children with acute lymphoblastic leukemia, 2 nutritional assessment at diagnosis and throughout treatment has become an important issue. It has now been pointed out that this is a decisive aspect of successful treatment.…”

Section: Introductionmentioning

confidence: 99%

Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study

et al. 2020

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BACKGROUND: Children with acute lymphoblastic leukemia are at risk of malnutrition, but few studies have described the changes in nutritional status during the different phases of chemotherapy. OBJECTIVE: To evaluate changes in nutritional status, food intake and appetite-regulating hormones among children and adolescents with acute lymphoblastic leukemia in the first phase of chemotherapy. DESIGN AND SETTING: Cohort study developed in the pediatric oncology departments of two hospitals in the city of Natal, Rio Grande do Norte, Brazil. METHODS: Fourteen children/adolescents (mean age of 7 years; 50% female) with acute lymphoblastic leukemia were monitored over the 28 days of an induction chemotherapy cycle. Anthropometric measurements, 24-hours food weight records and appetite-regulating hormone levels (ghrelin, leptin, insulin and cortisol) were obtained at three different times (before, in the middle and at the end of the induction phase). RESULTS: Most of the patients (85.7%) had normal weight at the beginning of the treatment, and this did not change significantly during the 28 days. Energy and nutrient intakes improved from the start of the treatment to the midpoint, according to the ghrelin levels (from 511.1 ± 8.3 to 519.3 ± 6.6 pg/ml; P = 0.027). Other appetite-regulating hormones did not present changes. CONCLUSION: Food consumption improves during the first phase of treatment, without alterations in anthropometric nutritional status.Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study | ORIGINAL ARTICLE

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Appetite hormones in children and adolescents with cancer: a systematic review of observational studies

Abstract: This review confirms that changes in the responses of the ghrelin and leptin hormones in children and adolescents with cancer are quite diverse, probably due to the different types of cancer observed, different treatments performed and biological characteristics of this age group.

Cited by 4 publications

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Quality of life in patients with breast cancer with neoadjuvant chemotherapy: a systematic review

Quality of life in patients with breast cancer with neoadjuvant chemotherapy: a systematic review

Mudanças ocorridas após diagnóstico e tratamento do câncer na perspectiva da criança

Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study

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