Brain abscess and cervical lymphadenitis due to Paraclostridium bifermentans : A report of two cases

R, Udhaya Sankar; Biswas, Rakhi; Raja, Satish; Sistla, Sujatha; Gopalakrishnan, Maya; Saxena, Sunil

doi:10.1016/j.anaerobe.2018.03.006

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…Our findings conveyed that two dominant genera, Paraclostridium in the CK group and Enterococcus in the SPH-treated group, could be responsible for the bacterial structure differences between SE–SSOs and SPH treatments. According to documents, some species of the genus Paraclostridium were proposed with pathogenic features, such as Paraclostridium dentum [ 38 ] and Paraclostridium bifermentans [ 39 ]. Decreases of the abundance of genus Paraclostridium in SPH–12 h or SPH–24 h compared to the CK group conveyed the good inhibitory effect of SPH on potential pathogenic Paraclostridium in SE–SSOs.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid

Zhu

Zou

et al. 2023

Molecules

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In order to further develop and utilize shrimp processing by-products, in this study, a novel antibacterial hydrolysate of shrimp by-products by pepsin hydrolysis (SPH) was prepared. The antibacterial effect of SPH on specific spoilage organisms of squid after end storage at room temperature (SE–SSOs) was investigated. SPH showed an antibacterial effect on the growth of SE–SSOs, with (23.4 ± 0.2) mm of inhibition zone diameter. The cell permeability of SE–SSOs was enhanced after SPH treatment for 12 h. Some bacteria were twisted and shrunk, while pits and pores formed and intracellular contents leaked under scanning electron microscopy observation. The flora diversity of SE–SSOs treated with SPH was determined by a 16S rDNA sequencing technique. Results showed that SE–SSOs were mainly composed of the phyla of Firmicutes and Proteobacteria, among which Paraclostridium (47.29%) and Enterobacter (38.35%) were dominant genera. SPH treatment resulted in a significant reduction in the relative abundance of the genus Paraclostridium and increased the abundance of Enterococcus. Linear discriminant analysis (LDA) of LEfSe conveyed that SPH treatment had a significant impact on altering the bacterial structure of SE–SSOs. The 16S PICRUSt of Cluster of Orthologous Group (COG) annotation revealed that SPH treatment for 12 h could significantly increase the function of transcription level [K], while SPH treatment for 24 h could downregulate post-translational modifications, protein turnover, and chaperone metabolism functions [O]. In conclusion, SPH has a proper antibacterial effect on SE–SSOs and can change the flora structure of SE–SSOs. These findings will provide a technical basis for the development of inhibitors of squid SSOs.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid

Zhu

Zou

et al. 2023

Molecules

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“…While we found no overall clustering among microbial communities at the genus level across health status, Paraclostridium bifermentans was significantly more abundant in oral microbiota of symptomatic chicks compared to other samples. P. bifermentans is an anaerobic pathogen that is associated with septic arthritis, osteomyelitis, inflammatory gastrointestinal disease, endocarditis, brain abscesses and lymphadenitis in humans (Kolander, 1989;Edagiz et al, 2015;Hale et al, 2016;Sankar R et al, 2018;Barrett et al, 2020;Zhao et al, 2022). Clostridial diseases have been known to affect avian hosts (Clark et al, 2010;Lueders et al, 2017;Videvall et al, 2020) including penguins ((Rohrer et al, 2023, and unpublished pathology reports), but it is typically only associated with inflammatory gastrointestinal disease and septic peritonitis.…”

Section: Discussionmentioning

confidence: 99%

Total infectome investigation of diphtheritic stomatitis in yellow-eyed penguins (Megadyptes antipodes) reveals a novel and abundant megrivirus

Wierenga,

Morgan,

Taylor

et al. 2023

Preprint

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First identified in 2002, diphtheritic stomatitis (DS) is a devastating disease affecting yellow-eyed penguins (Megadyptes antipodes, or hoiho in te reo Māori). The disease is associated with oral lesions in chicks and has caused significant morbidity and mortality. DS is widespread among yellow-eyed penguin chicks on mainland New Zealand yet appears to be absent from the subantarctic population. Corynebacterium spp. have previously been suspected as a causative agent yet, due to inconsistent cultures and inconclusive pathogenicity, its role in DS is unclear. Herein, we used a metatranscriptomic approach to identify potential causative agents of DS by revealing the presence and abundance of all viruses, bacteria, fungi and protozoa - together, the infectome. Oral and cloacal swab samples were collected from presymptomatic, symptomatic and recovered chicks along with a control group of healthy adults. Two novel viruses from the Picornaviridae were identified, one of which - yellow-eyed penguin megrivirus - was highly abundant in chicks irrespective of health status but not detected in healthy adults. Tissue from biopsied oral lesions also tested positive for the novel megrivirus upon PCR. We found no overall clustering among bacteria, protozoa and fungi communities at the genus level across samples, although Paraclostridium bifermentans was significantly more abundant in oral microbiota of symptomatic chicks compared to other groups. The detection of a novel and highly abundant megrivirus has sparked a new line of enquiry to investigate its potential association with DS.

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“…Of this group, C. bifermentans is often a non-pathogenic component that makes up a minor portion of the gut flora. From the literature review, this bacterium can lead to necrotizing endometritis, empyema, metastatic osteomyelitis, endocarditis, soft tissue infection, brain abscess, lymphadenitis, bacteremia, and panophthalmitis [2][3][4][5][6][7]. A study of the literature revealed one incidence of septic infection of a prosthetic joint in a 67-year-old man that was brought on by an isolated C. bifermentans and a case of septic arthritis of the knee joint due to C. bifermentans [8][9].…”

Section: Introductionmentioning

confidence: 99%

Clostridium Bifermentans Infection of a Prosthetic Knee Joint in a Patient With Human Immunodeficiency Virus: A Case Report

Moran,

Patel,

Kahlon

2023

Cureus

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We reported a case of Clostridium bifermentans (C. bifermentans) infection in the prosthetic knee joint of a human immunodeficiency virus (HIV) patient, who presented with swelling, discomfort, pain, and redness in the right lower extremity. An uncommon yet potentially lethal human illness triggered by C. bifermentans. Foreign material is especially susceptible to local infection because of the local immunodeficiency close to the implant. Intravenous (IV) cefepime and IV ampicillin/sulbactam were administered to the patient. The idea of performing surgery to eradicate the infection was under consideration, but its necessity remained uncertain, and the decision to proceed with surgery had not been finalized.

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Brain abscess and cervical lymphadenitis due to Paraclostridium bifermentans : A report of two cases

Cited by 9 publications

References 19 publications

Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid

Antibacterial Effect of Shrimp By-Products Hydrolysate on Specific Spoilage Organisms of Squid

Total infectome investigation of diphtheritic stomatitis in yellow-eyed penguins (Megadyptes antipodes) reveals a novel and abundant megrivirus

Clostridium Bifermentans Infection of a Prosthetic Knee Joint in a Patient With Human Immunodeficiency Virus: A Case Report

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