UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry1. We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes.

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Background:Previous in vitro studies indicated that dentin matrix protein 1 (DMP1) might regulate dentin sialophosphoprotein (DSPP) expression in odontoblasts. Results: Transgenic expression of DSPP rescued the tooth defects of Dmp1 knockout mice. Conclusion: DSPP is a downstream effector molecule of DMP1 in dentinogenesis. Significance: This study has identified the in vivo functional relationship of DMP1 and DSPP in dentinogenesis.