Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials

Shahdadian, Farnaz; Mohammadi, Hamed

doi:10.1055/s-0044-100616

Cited by 21 publications

(13 citation statements)

References 51 publications

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“…Neither did Suksomboon et al (245) (8 RCTs and 1,077 participants) find any effect of vitamin K supplementation on insulin sensitivity after observing no changes in the parameters analyzed such as insulin resistance, fasting plasma glucose, fasting plasma insulin, CRP, adiponectin, leptin, or IL-6 levels. Similar results were described in the meta-analysis by Shahdadian et al (246) in which vitamin K supplementation had no significant effect on glycemic control in healthy subjects.…”

Section: Vitaminssupporting

confidence: 89%

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

et al. 2019

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Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition. Plant-based dietary patterns, functional foods, dietary supplements, and bioactive compounds such as the Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 and ω-6, vitamins E, A, C, and D, coenzyme Q10, as well as phytochemicals including isoflavones, stilbenes, and sterols have been associated with improvement in atheroma plaque at an inflammatory level. However, many of these correlations have been obtained in vitro and in experimental animals' models. On one hand, the present review focuses on the evidence obtained from epidemiological, dietary intervention and supplementation studies in humans supporting the role of immunonutrient supplementation and its effect on anti-inflammatory response in atherosclerotic disease. On the other hand, this review also analyzes the possible molecular mechanisms underlying the protective action of these supplements, which may lead a novel therapeutic approach to prevent or attenuate diet-related disease, such as atherosclerosis.

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Section: Vitaminssupporting

confidence: 89%

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

et al. 2019

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“…Having said all that, in our previous study [ 24 ], fasting blood sugar was not significantly affected by 8 weeks of MK-7 consumption compared to administrating placebo capsules in PCOS patients. In line with the mentioned study, Shahdadian et al [ 39 ] in a systematic review and meta-analysis reported that vitamin K administration could not significantly affect glycemic control within healthy individuals. In another study [ 40 ], after 4 weeks of vitamin k2 administration by healthy young men, insulin sensitivity increased but fasting blood glucose did not significantly change.…”

Section: Discussionsupporting

confidence: 63%

Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial

et al. 2022

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Background Patients with Polycystic ovary syndrome (PCOS) are predisposed to the development of several mental comorbidities such as depression. According to several studies, PCOS can be managed by improving insulin sensitivity. The insulin-sensitizing effect of vitamin K has been reported in recent studies. Therefore, in the current trial, we assessed the effect of administrating vitamin K2 (Menaquinone-7) on depression status in women afflicted with PCOS. Methods Eighty-four PCOS women were allocated into the intervention and comparison groups; the intervention group (n = 42) administered 90 µg/day Menaquinone-7, and the comparison group (n = 42) consumed placebo capsules (containing avesil) for 8 weeks. In this randomized, double blind, placebo-controlled clinical trial, depression status was measured by BECK depression inventory-II (BDI-II) before and after 8 weeks of intervention. Results Consumption of Menaquinone-7 in comparison with the placebo capsules significantly improved depression status (P = 0.012). Conclusion This clinical study reported the advantageous effect of Menaquinone-7 administration on depression status in PCOS patients. Trial registration The present study was registered at http://www.IRCT.ir on 06/06/2018 (registration number: IRCT20170916036204N5).

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“…31 Thirdly, according to previous studies, vitamin K would be more effective for improving the glycemic control among subjects with impaired glucose tolerance, rather than among healthy individuals. 32 In light of this, the role of vitamin K in glycemic control seems to be notable in patients with DM, rather than among pre-diabetes. 7 As described in our previous study, 7 vitamin K can increase insulin sensitivity in skeletal muscle cells in several different ways.…”

Section: Discussionmentioning

confidence: 99%

<p>Effects of MK-7 Supplementation on Glycemic Status, Anthropometric Indices and Lipid Profile in Patients with Type 2 Diabetes: A Randomized Controlled Trial</p>

Karamzad¹,

Faraji²,

Adeli³

et al. 2020

DMSO

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Background: Type 2 diabetes mellitus (T2DM) is a prevalent disorder which accounts for 90-95% of diabetic patients. The aim of this study was to assess the effects of menaquinone (MK-7) supplementation on glycemic indices, anthropometric indices and lipid profile, among patients with T2DM. Methods: In this double-blind placebo-controlled randomized clinical trial, 60 men and women with T2DM were allocated equally into either the MK-7 (200 µg/day) or the placebo group. Physical activity level and dietary intake were assessed using the international physical activity questionnaire-short form (IPAQ-SF) and a 3-day food record, pre-and post-intervention. Anthropometric measures, blood pressure, glycemic indices and lipid profile including fasting blood sugar (FBS), hemoglobin A1c (HBA1C), fasting insulin (FI), homeostatic model assessment insulin resistance index (HOMA-IR), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were measured at baseline and after twelve weeks. Results: Forty-five patients completed the trial. There were no significant between-group differences for calorie intake, macronutrient intake, physical activity level or anthropometric measures at baseline and at the end of the study. Dietary vitamin K intake increased significantly at the end of the study in the MK-7 (p: 0.02) and placebo (p: 0.001) groups, but intergroup differences were not significant (p: 0.86). FBS (p: 0.01), HbA1c (p: 0.002), fasting insulin (p: 0.01) and HOMA-IR (p: 0.007) decreased significantly in the MK-7 group. Furthermore, after adjustment for the baseline values and changes of vitamin K intake at the end of study, FBS and HbA1C showed significant intergroup changes, and they were significantly lower in the MK-7 group compared to the placebo group. Lipid profile (TG, TC, LDL-C, HDL-C and LDL-C/HDL-C) did not change significantly within or between groups. Conclusion: MK-7 supplementation seems to be effective in the improvement of glycemic indices, but not the lipid profile of patients with T2DM. Clinical Trial Registration: The present study was prospectively registered at the Iranian Registry of Clinical Trials on May 2019 (ID: IRCT20100123003140N22).

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Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials

Cited by 21 publications

References 51 publications

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial

<p>Effects of MK-7 Supplementation on Glycemic Status, Anthropometric Indices and Lipid Profile in Patients with Type 2 Diabetes: A Randomized Controlled Trial</p>

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