Impulsivity and Comorbid PTSD and Binge Drinking

Walker, John L.; Bountress, Kaitlin; Calhoun, Casey D.; Metzger, Isha W.; Adams, Zachary W.; Amstadter, Ananda B.; Thomas, Suzanne; Danielson, Carla Kmett

doi:10.1080/15504263.2018.1439212

Cited by 14 publications

(6 citation statements)

References 36 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rationale for establishing a drinking minimum frequency was to exclude infrequent drinkers and reduce the variability in the data due to frequency of drinking. This definition is consistent with that in existing literature (Walker et al, 2018). Individuals meeting basic eligibility criteria as determined by the preliminary phone or web-based screen came in for an office screening visit assessment to determine trauma group status and guarantee eligibility for the parent study laboratory visit.…”

Section: Methodssupporting

confidence: 92%

A cluster-analytic approach to determining drinking motives and personality typologies: Trauma group differences and respective relations to PTSD and problematic alcohol use.

Hawn¹,

Kurtz²,

Brown³

et al. 2018

Psychology of Addictive Behaviors

Self Cite

View full text Add to dashboard Cite

Veterans with posttraumatic stress disorder (PTSD) are at elevated risk for alcohol use problems, a relationship commonly explained by using alcohol to cope with unpleasant symptoms of PTSD. However, patterns of alcohol use motives, more broadly, have not been well characterized in veteran samples, nor have they been evaluated in the context of other relevant factors, such as normative personality traits. The aims of the present study were to identify empirically derived drinking motive and personality typologies to determine whether these typologies differ as a function of PTSD status (i.e., nontrauma control, trauma exposed-no PTSD, and PTSD) and to evaluate associations between typology and PTSD symptom severity and alcohol consumption, respectively. Cluster analyses identified a 4-cluster solution. Results indicated that these typologies differed significantly according to trauma group as well as across levels of PTSD symptom severity and alcohol use. Specifically, Cluster 4 represented individuals at highest risk for both PTSD symptom severity and alcohol use compared to all the other typologies; Cluster 1 demonstrated lowest risk for PTSD symptom severity and alcohol use compared to all other typologies; and although Clusters 2 and 3 did not differ according to PTSD symptom severity, individuals in Cluster 2 had significantly higher alcohol use. These results represent certain "at risk" versus "protective" typologies that may facilitate the identification of individuals at risk for comorbid PTSD and problematic alcohol use. (PsycINFO Database Record

show abstract

Section: Methodssupporting

confidence: 92%

A cluster-analytic approach to determining drinking motives and personality typologies: Trauma group differences and respective relations to PTSD and problematic alcohol use.

Hawn¹,

Kurtz²,

Brown³

et al. 2018

Psychology of Addictive Behaviors

Self Cite

View full text Add to dashboard Cite

show abstract

“…Behavioral endophenotypes are more closely related to the abnormalities that characterize these disorders and have the potential to integrate many different underlying genetic and environmental factors, in effect providing a valuable summary of data that might otherwise be prohibitively difficult or impossible to get (Gottesman and Gould, 2003). One such endophenotype that has been consistently associated with both PTSD and SUD is impulsivity (Weiss et al, 2013;James et al, 2014;Walker et al, 2018;Grubbs and Chapman, 2019). Impulsivity is a multifaceted concept in research but can be broadly defined as a tendency to engage in risky, premature, or situationally inappropriate actions that are characterized by a lack of planning or forethought (Robbins et al, 2012;Jentsch et al, 2014;Dalley and Robbins, 2017).…”

Section: Personality/behavioral Traitsmentioning

confidence: 99%

Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders

Maria-Rios

Morrow

2020

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Psychoactive substance use is a nearly universal human behavior, but a significant minority of people who use addictive substances will go on to develop an addictive disorder. Similarly, though ∼90% of people experience traumatic events in their lifetime, only ∼10% ever develop post-traumatic stress disorder (PTSD). Substance use disorders (SUD) and PTSD are highly comorbid, occurring in the same individual far more often than would be predicted by chance given the respective prevalence of each disorder. Some possible reasons that have been proposed for the relationship between PTSD and SUD are self-medication of anxiety with drugs or alcohol, increased exposure to traumatic events due to activities involved in acquiring illegal substances, or addictive substances altering the brain's stress response systems to make users more vulnerable to PTSD. Yet another possibility is that some people have an intrinsic vulnerability that predisposes them to both PTSD and SUD. In this review, we integrate clinical and animal data to explore these possible etiological links between SUD and PTSD, with an emphasis on interactions between dopaminergic, adrenocorticotropic, GABAergic, and glutamatergic neurobehavioral mechanisms that underlie different emotional learning styles.

show abstract

“…Participants were recruited to one of three study groups: non-trauma exposed control (controls), trauma exposed without PTSD (TE), or trauma exposed with PTSD. See prior work for information for eligibility details ( 38 ). Of those, 72 controls, 72 TE, and 53 PTSD participants ( n = 197) provided blood samples for genomic analyses.…”

Section: Methodsmentioning

confidence: 99%

Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: The purpose of this study was to identify gene expression differences associated with post-traumatic stress disorder (PTSD) and trauma exposure (TE) in a three-group study design comprised of those with and without trauma exposure and PTSD.Methods: We conducted gene expression and gene network analyses in a sample (n = 45) composed of female subjects of European Ancestry (EA) with PTSD, TE without PTSD, and controls.Results: We identified 283 genes differentially expressed between PTSD-TE groups. In an independent sample of Veterans (n = 78) a small minority of these genes were also differentially expressed. We identified 7 gene network modules significantly associated with PTSD and TE (Bonferroni corrected p ≤ 0.05), which at a false discovery rate (FDR) of q ≤ 0.2, were significantly enriched for biological pathways involved in focal adhesion, neuroactive ligand receptor interaction, and immune related processes among others.Conclusions: This study uses gene network analyses to identify significant gene modules associated with PTSD, TE, and controls. On an individual gene level, we identified a large number of differentially expressed genes between PTSD-TE groups, a minority of which were also differentially expressed in the independent sample. We also demonstrate a lack of network module preservation between PTSD and TE, suggesting that the molecular signature of PTSD and trauma are likely independent of each other. Our results provide a basis for the identification of likely disease pathways and biomarkers involved in the etiology of PTSD.

show abstract

Impulsivity and Comorbid PTSD and Binge Drinking

Abstract: Young adults who report difficulty attending to immediate stimuli within their environment may be unable to think about and/or process the traumatic event, potentially increasing risk for PTSD and maladaptive coping skills to manage this distress (e.g., alcohol misuse, binge drinking).

Cited by 14 publications

References 36 publications

A cluster-analytic approach to determining drinking motives and personality typologies: Trauma group differences and respective relations to PTSD and problematic alcohol use.

A cluster-analytic approach to determining drinking motives and personality typologies: Trauma group differences and respective relations to PTSD and problematic alcohol use.

Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders

Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder

Contact Info

Product

Resources

About