Effects of a hypoenergetic diet rich in α-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome

Egert, Sarah; Baxheinrich, Andrea; Lee-Barkey, Young Hee; Tschöepe, Diethelm; Stehle, Peter; Stratmann, Bernd; Wahrburg, Ursel

doi:10.1016/j.nut.2017.11.002

Cited by 24 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that ALA intake is linearly and negatively correlated with mortality rate associated with coronary heart disease (Wei et al, 2018). It can also reduce body fat and inhibit the proliferation of the human breast cancer cell line BT-474 (Mason et al, 2015;Egert et al, 2018). In this study, the ALA content was 0.133 ± 0.066 nmol/mL in DC and 0.532 ± 0.100 nmol/mL in DMM.…”

Section: Discussionsupporting

confidence: 47%

Comparative exploration of free fatty acids in donkey colostrum and mature milk based on a metabolomics approach

Liu

et al. 2020

Journal of Dairy Science

View full text Add to dashboard Cite

Donkey milk is an ideal substitute for human milk owing to its similar composition. Nevertheless, changes in the composition and related metabolic pathways of free fatty acids (FFA) in donkey milk between colostrum and mature milk have not been studied well. In this study, metabolomic methods based on gas chromatography tandem time-of-flight mass spectrometry (GC-TOF-MS) were used to explore and compare FFA in donkey colostrum (DC) and mature milk (DMM). A total of 24 FFA were characterized and quantified in DC and in DMM. Of these, 11 FFA differed significantly between DC and DMM, and there were 6 key differential metabolic pathways. These results demonstrated that the composition of FFA in donkey milk changed with lactation stage. The interactions and metabolic pathways were further analyzed to explore the mechanisms that altered the milk composition during lactation. Our results provide insights into the changes in milk of the nonruminant mammals during lactation. The results provide practical information for the development of donkey milk products and a foundation for future research on specific milk nutrients.

show abstract

Section: Discussionsupporting

confidence: 47%

Comparative exploration of free fatty acids in donkey colostrum and mature milk based on a metabolomics approach

Liu

et al. 2020

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…Lee et al consider APF to be related to metabolic syndrome (MetS) and can be evaluated within the range of disorders, including glucose intolerance, dyslipidemia, and hypertension (10). Higher BMI and being overweight can lead to MetS (11,12). The present study identified smoking to be associated with a high risk of APF in the study patients, although it is not conclusive whether smoking is a risk factor of APF in the literature (4,5).…”

Section: Discussionmentioning

confidence: 51%

Application value of dual-energy computed tomography spectrum curve combined with clinical risk factors in predicting adherent perinephric fat

Guan

Huang

et al. 2019

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

Background: Adherent perinephric fat (APF) is evaluated preoperatively with the Mayo adhesive probability (MAP) scoring system using conventional single form computed tomography (CT) images. An objective or quantitative indicator for predicting APF is urgently needed for clinical application. Methods: Data obtained from 150 renal tumor patients with partial nephrectomy (PN) were used in the present study. Patients were divided into two groups based on the surgical results: an APF group (n=100) and a non-APF group (n=50). All patients had renal contrast-enhanced dual-energy CT (DECT) scan, and the data were brought into a post-processing workstation. Monoenergetic plus mode was adopted to analyze the spectrum curve of the region of interest (ROI). Logistic stepwise relapse investigation was utilized to analyze the related risk factors. The maximum Youden index was taken as the cutoff value. The sensitivity, specificity, accuracy, and 95% CI of the model were calculated. Results: APF is related to patients' clinical characteristics of age, gender, BMI, smoking, tumor diameter, exophytic, and benign or malignant nature of the renal masses (P<0.05). The shape of the curve of ROI 1 in the APF group was different from that of the ROI 4 in the non-APF group, and the curve slope of K1 (−0.21±0.47) was different from that of K4 (−1.30±0.14) (P<0.001). Statistical analysis showed that the slope K was solely retained in the model index. The best cutoff point for the K value was −0.95. The AUC of the cutoff point was 0.97 (95% CI: 0.96−0.99). Conclusions: The DECT spectrum curve performed well in predicting APF, and the curve slope K can be used as an objective quantitative indicator.

show abstract

“…23 In support of this consideration, statins were reported to decrease global inflammation 24 and improve symptoms of patients affected by depression. 25 Regarding the second point, changes in dietary habits (e.g., by enrichment in ALA or directly supplying ALA long-chain omega-3 derivatives) may modify serum u3 PUFAs, 26,27 further improving the overall lipid profile 28 through the modulation of cholesterol transport. 29 The limitations of the present investigation are consistent with those of all cross-sectional study designs.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Cholesterol and Fatty Acid Profile on the Severity of Depression in Older Persons With Nondialysis Chronic Kidney Disease

Buoli

Caldiroli

Guenzani

et al. 2021

Journal of Renal Nutrition

View full text Add to dashboard Cite

Depressive symptoms worsen the outcomes of patients affected by chronic kidney disease (CKD). The purpose of the present article is to study the association between serum lipid profile and the severity of depression in patients with CKD. We evaluated 132 older subjects with advanced CKD (stage 3-5, not receiving dialysis) in regular follow-up in a nephrology clinic. Blood samples were collected after an overnight fast. All patients were evaluated with the Geriatric Depression Scale which is comprised of 30 items that assess the severity of depressive symptoms. A backward multivariate regression analysis was performed to study the association between lipid profile and severity of depression. Low-density lipoprotein levels (b 5 2.77, P 5 .008) and arachidonic acid/linoleic acid ratio (b 5 2.51, P 5 .015) were found to be significantly associated with severity of depressive symptoms. Change in dietary habits or the use of hypocholesterolemic drugs could potentially prevent depressive symptoms and ameliorate outcome of patients affected by CKD. Data from prospective studies are needed to confirm these preliminary results.

show abstract

Effects of a hypoenergetic diet rich in α-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome

Cited by 24 publications

References 41 publications

Comparative exploration of free fatty acids in donkey colostrum and mature milk based on a metabolomics approach

Comparative exploration of free fatty acids in donkey colostrum and mature milk based on a metabolomics approach

Application value of dual-energy computed tomography spectrum curve combined with clinical risk factors in predicting adherent perinephric fat

Associations Between Cholesterol and Fatty Acid Profile on the Severity of Depression in Older Persons With Nondialysis Chronic Kidney Disease

Contact Info

Product

Resources

About