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Chronic renal failure (CRF) is a frequent condition in elderly subjects, and it is associated with psychiatric comorbidity, especially depressive symptoms. Purpose of the present research was to compare patients with different severity of chronic kidney disease (CKD) in terms of psychiatric symptoms. One hundred CKD subjects were randomly selected among those attending the Department of Nephrology, University of Milan. The patients were evaluated through the following rating scales: Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), Symptom Checklist (SCL-90), Kidney Disease Quality of Life- Short Form (KDQOL-SF) and Cumulative Illness Rating Scale (CIRS). A multivariable linear regression analysis was performed considering eGFR as continuous-dependent variable and rating scale scores as independent variables. A worse eGFR significantly correlated with the score about the effects of kidney disease on daily life (r = 0.25, p = 0.01) and the burden of kidney disease (r = 0.18, p = 0.05). Statistical significance of kidney disease on daily life persisted also in the final multivariate model (t = 2.04, p = 0.04). Severity of renal dysfunction seems to influence few psychiatric outcomes, particularly those related to quality of life and daily functioning. This result might depend on the over-worrying derived from the necessity to start a renal replacement therapy in the near future.

Depressive symptoms worsen the outcomes of patients affected by chronic kidney disease (CKD). The purpose of the present article is to study the association between serum lipid profile and the severity of depression in patients with CKD. We evaluated 132 older subjects with advanced CKD (stage 3-5, not receiving dialysis) in regular follow-up in a nephrology clinic. Blood samples were collected after an overnight fast. All patients were evaluated with the Geriatric Depression Scale which is comprised of 30 items that assess the severity of depressive symptoms. A backward multivariate regression analysis was performed to study the association between lipid profile and severity of depression. Low-density lipoprotein levels (b 5 2.77, P 5 .008) and arachidonic acid/linoleic acid ratio (b 5 2.51, P 5 .015) were found to be significantly associated with severity of depressive symptoms. Change in dietary habits or the use of hypocholesterolemic drugs could potentially prevent depressive symptoms and ameliorate outcome of patients affected by CKD. Data from prospective studies are needed to confirm these preliminary results.

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Introduction and Aims: Patients affected by chronic kidney disease (CKD) have a high cardiovascular risk. Blood pressure (BP) is one of the principal factors to control to reduce cardiovascular mortality. Several studies have reported that ambulatory blood pressure measurement (ABPM) have a higher accuracy and sensitivity in detect hypertensive patients than office blood pressure (OBP) in general population. The aims of our study are to evaluate, in a cohort of CKD patients undergone at two timepoints, T1 and T2 (median time between the two evaluation 17 mths) to ABPM: 1) the relation between office blood pressure (OBP) and ABPM blood pressure; 2) the clinical and biochemical factors correlated with ABPM parameters and with dipping; 3) the prevalence of the different category of dipping and its modification between T1 and T2 Methods: 150 patients (age 72±9 yrs -67% males -54% diabetics -98% hypertensive) affected by CKD stages I-IV were enrolled and undergone at T1 and T2 to ABPM. At the same timepoints clinical, blood and urinary evaluations were performed. The

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