<scp>WBC</scp> alloimmunization: effects on the laboratory and clinical endpoints of therapeutic granulocyte transfusions

Price, Thomas H.; McCullough, Jeffrey; Strauss, Ronald G.; Ness, Paul M.; Hamza, Taye H.; Harrison, Ryan W.; Assmann, Susan F.

doi:10.1111/trf.14551

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…23 However, more recent studies have not substantiated such risks. 24 Therefore, the principle of non-maleficence is primarily relevant in relation to the donor.…”

Section: How To Make Sense Of These Data From An Ethical Perspective?mentioning

confidence: 99%

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The ethical dilemma of granulocyte transfusions

2020

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Granulocyte transfusions have been administered to patients with life-threatening infections for more than five decades. However, to what extent this should be the case is far from established. On the one hand, the clinical effects of these transfusions are difficult to prove in clinical studies, and the donors of granulocytes may be exposed to certain risks. On the other hand, clinical experience seems to support the idea that granulocyte transfusions do play an important role for severely ill patients, and the donors are primarily motivated by altruistic reasons. In this paper, we first discuss the ethical issues that arise from the fact that there is a conflict between clinical experience and the results from the attempts to perform randomized control trials, and second, the risk/benefit assessment that has to be made between two different parties, namely the recipient and the donor of granulocyte transfusions.

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“…23 However, more recent studies have not substantiated such risks. 24 Therefore, the principle of non-maleficence is primarily relevant in relation to the donor.…”

Section: How To Make Sense Of These Data From An Ethical Perspective?mentioning

confidence: 99%

“…There is a sense in which granulocyte transfusions may affect the health of third parties. A follow up of the RING study 24 investigated immunization after granulocyte transfusions. Increased immunization could not be detected after short-term observation of the patients.…”

Section: How To Make Sense Of These Data From An Ethical Perspective?mentioning

confidence: 99%

The ethical dilemma of granulocyte transfusions

2020

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“…In their recently published report “WBC alloimmunization and their effects on laboratory and clinical therapeutic granulocyte transfusions,” Price et al conclude after statistical analysis of 114 subjects of the RING study that: “The presence or development of WBC antibodies had no demonstrable effect on any clinical aspect of granulocyte transfusion. It appears that, at least in the patient population study, there is no evidence suggesting need for concern about recipient WBC alloimmunization when prescribing granulocyte transfusions” …”

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confidence: 97%

Be alert to leukocyte antibodies when prescribing granulocyte transfusions

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Sachs

2019

Transfusion

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“…While this hardening experience might deter future orders, and indicated the need to design guidelines and give leverage to enforce usage contracts, it also was an effective impetus for us to update the granulocyte order and transfusion protocols. This exercise included developing a workflow outline with brief scripts that trainees and staff may use to converse with clinicians and donor center representatives.…”

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confidence: 99%