A novel flurophore-cyano-carboxylic-Ag microhybrid: Enhanced two photon absorption for two-photon photothermal therapy of HeLa cancer cells by targeting mitochondria

Kong, Lin; Yang, Li; Xin, Chenqi; Zhu, Shu-Juan; Zhang, Huihui; Zhang, Mingzhu; Yang, Jiaxiang; Li, Lin; Zhou, Hu; Tian, Yupeng

doi:10.1016/j.bios.2018.02.028

Cited by 12 publications

(2 citation statements)

References 29 publications

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“…The AuNSs codecorated with the cationic peptide R8 and proapoptotic peptide TPP-KLA acted as a Mc-targeting nanoheater for NIR-triggered PTT. 58 Kong et al 146 designed a microhybrid with two-photon absorption characteristics through coordination interactions between silver and a fluorescent cyano-carboxylic acid derivative. The decreased quantum fluorescence and improved two-photon absorption caused by the surface plasmon resonance effect led to good photothermal output in Mc of HeLa cancer cells when radiation at 780 nm.…”

Section: Stimuli-responsive Characteristics Of St-mc-ddssmentioning

confidence: 99%

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Huang

Wang

Tan

et al. 2021

IJN

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Dysfunction in the mitochondria (Mc) contributes to tumor progression. It is a major challenge to deliver therapeutic agents specifically to the Mc for precise treatment. Smart drug delivery systems are based on stimuli-responsiveness and active targeting. Here, we give a whole list of documented pathways to achieve smart stimuli-responsive (St-) and Mc-targeted DDSs (St-Mc-DDSs) by combining St and Mc targeting strategies. We present the formulations, targeting characteristics of St-Mc-DDSs and clarify their anti-cancer mechanisms as well as improvement in efficacy and safety. St-Mc-DDSs usually not only have Mc-targeting groups, molecules (lipophilic cations, peptides, and aptamers) or materials but also sense the surrounding environment and correspondingly respond to internal biostimulators such as pH, redox changes, enzyme and glucose, and/or externally applied triggers such as light, magnet, temperature and ultrasound. St-Mc-DDSs exquisitely control the action site, increase therapeutic efficacy and decrease side effects of the drug. We summarize the clinical research progress and propose suggestions for follow-up research. St-Mc-DDSs may be an innovative and sensitive precision medicine for cancer treatment.

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Section: Stimuli-responsive Characteristics Of St-mc-ddssmentioning

confidence: 99%

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Huang

Wang

Tan

et al. 2021

IJN

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“…2 nanoprobes based on the survivin mRNA overexpressed in tumor cells, realizing the intracellular self-assembly of gold nanoparticles (Au NPs) and promoting the PTT effect of the Au aggregates on tumor cells . PTT is a hyperthermia cancer treatment that utilizes specific near-infrared light-responsive nanomaterials or molecules to generate localized heat using laser ablation. − However, this treatment usually requires ablation of the tumor at a high temperature above 50 °C, which inevitably causes thermal damage to the surrounding normal tissues . Therefore, there is an urgent need to adopt a strategy of achieving mild PTT at lower temperatures to overcome the tumor cells’ thermotolerance problem …”

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confidence: 99%

Self-Assembly-Based Nanoprobes for the Simultaneous Detection and Downregulation of HSP90α mRNA to Enhance Photothermal Therapy

et al. 2023

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Although photothermal therapy (PTT) has been widely applied for tumor treatment, tumor cells thermotolerance still limits PTT efficiency. Since the overexpressed HSP90α in tumor cells further enhances thermotolerance and protects them from PTT damage, a new nanoprobe that can specifically detect and downregulate HSP90α mRNA was developed to enhance the PTT effect. Based on the HSP90α mRNA sequence, the nanoprobe Au-DNA1/DNA2 can specifically bind to HSP90α mRNA for recovering its fluorescence and further inhibit the synthesis of HSP90α to reduce tumor heat tolerance. Moreover, another nanoprobe, Au-DNA3, can self-assemble with the Au-DNA1 nanoprobe after the detection to form Au aggregations to enhance PTT afterward for better efficiency. Simultaneously, such a design improves tissue penetration and tumor retention, thereby reducing the damage to the surrounding normal tissues. Both in vitro and in vivo experiments showed that the nanoprobes have excellent tumor diagnosis and cancer treatment capabilities, which is of great significance for clinical translational applications.

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Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

Wang

et al. 2021

Adv Healthcare Materials

250

145

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It is of great significance to develop anticancer therapeutic agents or technologies with high degree of specificity and patient compliance, while low toxicity. The emerging photothermal therapy (PTT) has become a new and powerful therapeutic technology due to its noninvasiveness, high specificity, low side effects to normal tissues and strong anticancer efficacy. Noble metal nanomaterials possess strong surface plasmon resonance (SPR) effect and synthetic tunability, which make them facile and effective PTT agents with superior optical and photothermal characteristics, such as high absorption cross‐section, incomparable optical‐thermal conversion efficiency in the near infrared (NIR) region, as well as the potential of bioimaging. By incorporating with various functional reagents such as antibodies, peptides, biocompatible polymers, chemo‐drug and immune factors, noble metal nanomaterials have presented strong potential in multifunctional cancer therapy. Herein, the recent development regarding the application of noble metal nanomaterials for NIR‐triggered PTT in cancer treatment is summarized. A variety of studies with good therapeutic effects against cancer from impressive photothermal efficacy of noble metal nanomaterials are concluded. Intelligent nanoplatforms through ingenious fabrication showing potential of multifunctional PTT, combined with chemo‐therapy, immunotherapy, photodynamic therapy (PDT), as well as simultaneous imaging modality are also demonstrated.

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A novel flurophore-cyano-carboxylic-Ag microhybrid: Enhanced two photon absorption for two-photon photothermal therapy of HeLa cancer cells by targeting mitochondria

Cited by 12 publications

References 29 publications

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Self-Assembly-Based Nanoprobes for the Simultaneous Detection and Downregulation of HSP90α mRNA to Enhance Photothermal Therapy

Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

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